Carli D. Needle
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View article: Patient Perspectives Regarding Artificial Intelligence-Driven Trichoscopy for Alopecia Evaluation
Patient Perspectives Regarding Artificial Intelligence-Driven Trichoscopy for Alopecia Evaluation Open
Introduction: Alopecia treatment can improve patients’ quality of life, but slow hair regrowth makes progress difficult to detect. Trichoscopic measurements (TMs; hair density, hairs/cm2; hair caliber, µm) provide an objective method for m…
View article: Topical Tacrolimus, Clobetasol, and Minoxidil for Primary Cicatricial Alopecias: A Retrospective Analysis of Clinical Outcomes and Safety
Topical Tacrolimus, Clobetasol, and Minoxidil for Primary Cicatricial Alopecias: A Retrospective Analysis of Clinical Outcomes and Safety Open
Introduction: Primary cicatricial alopecias (PCAs) cause permanent hair loss and psychosocial distress. Management involves anti-inflammatory and hair growth-promoting therapies. A combination of tacrolimus, clobetasol, and minoxidil (TCM)…
View article: Successful Treatment of Coexisting Alopecia Areata and Bullous Pemphigoid With Dupilumab: A Case Report
Successful Treatment of Coexisting Alopecia Areata and Bullous Pemphigoid With Dupilumab: A Case Report Open
Alopecia areata (AA) and bullous pemphigoid (BP) are distinct autoimmune diseases, but growing evidence points to overlapping immune pathways. We present a rare case of a 71‐year‐old woman with concurrent AA and BP. She initially presented…
View article: Evaluating Scarring Alopecia Therapies from the Patient Perspective: Knowledge, Barriers to Care, and Treatment Satisfaction
Evaluating Scarring Alopecia Therapies from the Patient Perspective: Knowledge, Barriers to Care, and Treatment Satisfaction Open
Introduction: Scarring alopecias (SAs) cause permanent hair loss and psychological distress. With no FDA-approved SA treatments, patients face significant barriers to care. Despite promising evidence supporting the use of Janus kinase inhi…
View article: Alopecia in Female Athletes Using Androgenic and Anabolic Steroids: Pathophysiology and Management
Alopecia in Female Athletes Using Androgenic and Anabolic Steroids: Pathophysiology and Management Open
Performance‐enhancing substances (PES) are used by many athletes worldwide to improve performance and enhance appearance. Although PES are more commonly used by men, use is increasing among women, leading to growing physical and psychosoci…
View article: Impact of Age on Response to Platelet-Rich Plasma Therapy
Impact of Age on Response to Platelet-Rich Plasma Therapy Open
Although platelet-rich plasma (PRP) is a widely used treatment for androgenetic alopecia (AGA), the impact of patient age on treatment efficacy remains underexplored. This retrospective study evaluated PRP outcomes in 57 AGA patients treat…
View article: Gastrointestinal colonization as a source of <i>Staphylococcus aureus</i> in atopic dermatitis
Gastrointestinal colonization as a source of <i>Staphylococcus aureus</i> in atopic dermatitis Open
Atopic dermatitis (AD) is a prevalent inflammatory skin disease with complex pathogenesis. Both skin and gut microbiota influence AD, with Staphylococcus aureus , in particular, exacerbating the disease. However, the relationship between S…
View article: Premature hair graying: a multifaceted phenomenon
Premature hair graying: a multifaceted phenomenon Open
Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, …
View article: Cutaneous Toxicities of <scp>MEK</scp> Inhibitor Use in Children: A Comparison of Binimetinib and Selumetinib
Cutaneous Toxicities of <span>MEK</span> Inhibitor Use in Children: A Comparison of Binimetinib and Selumetinib Open
Background Binimetinib and selumetinib are two mitogen‐activated protein kinase kinase (MEK) inhibitors used to treat low‐grade gliomas and plexiform neurofibromas. Cutaneous toxicities are commonly associated with MEK inhibitors; however,…
View article: Efficacy of a dermatology interest group-sponsored biopsy and suturing workshop for medical students
Efficacy of a dermatology interest group-sponsored biopsy and suturing workshop for medical students Open
To the Editor: Despite the global prevalence of skin disease, most medical schools offer limited instruction in both medical and procedural dermatology.1Blakely K. Bahrani B. Doiron P. Dahlke E. Early introduction of dermatology clinical s…
View article: The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration Open
Throughout their lifetime, fish maintain a high capacity for regenerating complex tissues after injury. We utilized a larval tail regeneration assay in the zebrafish Danio rerio , which serves as an ideal model of appendage regeneration du…
View article: Integrating structural and evolutionary data to interpret variation and pathogenicity in adapter protein complex 4
Integrating structural and evolutionary data to interpret variation and pathogenicity in adapter protein complex 4 Open
Genetic variation in the membrane trafficking adapter protein complex 4 (AP‐4) can result in pathogenic neurological phenotypes including microencephaly, spastic paraplegias, epilepsy, and other developmental defects. We lack molecular mec…
View article: A metabolic shift to glycolysis promotes zebrafish tail regeneration through TGF–β dependent dedifferentiation of notochord cells to form the blastema
A metabolic shift to glycolysis promotes zebrafish tail regeneration through TGF–β dependent dedifferentiation of notochord cells to form the blastema Open
Mammals are generally poor at tissue regeneration, in contrast, fish maintain a high capacity for regenerating complex tissues after injury. Using larval zebrafish, we show that tail amputation triggers an metabolic shift to glycolysis in …