David D. Nolte
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View article: Role of Intersections in Fracture Connectivity
Role of Intersections in Fracture Connectivity Open
Networks of intersecting fractures often provide the flow paths through subsurface reservoirs. Assessing network connectivity is challenging because fracture intersections compose a vanishingly small fraction of the network void volume. In…
View article: Exploring tumor dynamics and responses of prostate cancer to IL-27 based treatment combinations through biodynamic imaging and RNA sequencing analyses
Exploring tumor dynamics and responses of prostate cancer to IL-27 based treatment combinations through biodynamic imaging and RNA sequencing analyses Open
The tumor microenvironment (TME) is a highly dynamic network shaped by immune, vascular, and stromal interactions, further modulated by extracellular factors. The high tumor heterogeneity complicates treatment due to evolving resistance. B…
View article: Monitoring Fracture Hydromechanical Evolution in the Lab and Field Using Unsupervised Metric Learning
Monitoring Fracture Hydromechanical Evolution in the Lab and Field Using Unsupervised Metric Learning Open
Fractures evolve in time through thermal‐hydraulic‐mechanical‐chemical (THMC) processes that alter their long‐range hydraulic transport properties and modify subsurface behavior and activities. The location of subsurface fractures makes it…
View article: Intracellular doppler spectroscopy of live tissue sentinels for a fast in-vitro bacterial infection assay
Intracellular doppler spectroscopy of live tissue sentinels for a fast in-vitro bacterial infection assay Open
Living organisms are frequently used as sentinels to monitor changes in the environment, and organoids can serve a similar function as in vitro sentinels detecting microbiological processes. One such process of great interest is pathogenic…
View article: Fresnel biprism common-path low-coherence digital holography for dynamic light scattering spectroscopy of biological materials
Fresnel biprism common-path low-coherence digital holography for dynamic light scattering spectroscopy of biological materials Open
Doppler frequency shifts associated with the motions in cells range from mHz to Hz, requiring ultra-stable interferometry to capture frequency offsets at several parts in 10 18 . Common-path interferometers minimize the influence of mechan…
View article: Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma
Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma Open
Background Esophageal cancer management lacks reliable response predictors to chemotherapy. In this study we evaluated the feasibility and accuracy of Biodynamic Imaging (BDI), a technology that employs digital holography as a rapid predic…
View article: Coherent light scattering from cellular dynamics in living tissues
Coherent light scattering from cellular dynamics in living tissues Open
This review examines the biological physics of intracellular transport probed by the coherent optics of dynamic light scattering from optically thick living tissues. Cells and their constituents are in constant motion, composed of a broad …
View article: Comparative oncology chemosensitivity assay for personalized medicine using low-coherence digital holography of dynamic light scattering from cancer biopsies
Comparative oncology chemosensitivity assay for personalized medicine using low-coherence digital holography of dynamic light scattering from cancer biopsies Open
Nearly half of cancer patients who receive standard-of-care treatments fail to respond to their first-line chemotherapy, demonstrating the pressing need for improved methods to select personalized cancer therapies. Low-coherence digital ho…
View article: Editorial Introduction to JSTQE Special Issue on Biophotonics (2023)
Editorial Introduction to JSTQE Special Issue on Biophotonics (2023) Open
Biophotonics is a research and technology field that sits at the interface of photonics and biomedical applications, which includes clinical diagnosis, therapeutics, biotechnology, and the environment. The integration of optics and biology…
View article: Chemosensitivity testing of revived fresh-frozen biopsies using digital speckle holography
Chemosensitivity testing of revived fresh-frozen biopsies using digital speckle holography Open
Enrolling patients in clinical trials to obtain fresh tumor biopsies to profile anticancer agents can be slow and expensive. However, if flash-frozen biopsies can be thawed to produce viable living tissue with relevant biodynamic profiles,…
View article: Convergence analysis of pressure reconstruction methods from discrete velocities
Convergence analysis of pressure reconstruction methods from discrete velocities Open
Magnetic resonance imaging allows the measurement of the three-dimensional velocity field in blood flows. Therefore, several methods have been proposed to reconstruct the pressure field from such measurements using the incompressible Navie…
View article: System and method of mapping topology
System and method of mapping topology Open
A system for determining a fingerprint of a structure is provided. The system includes a plurality of granules inserted in a structure having a plurality of fissures, fractures, and cracks (collectively apertures), each granule comprising …
View article: Monitoring Fracture Saturation using Transportable Acoustic Sources and a Neural Network Differential Autoencoder
Monitoring Fracture Saturation using Transportable Acoustic Sources and a Neural Network Differential Autoencoder Open
Acoustic signals from transportable acoustic sources were analysed using a Siamese twin neural network differential autoencoder (TDAE) to monitor changing fracture saturation within a laboratory testbed consisting of synthetic fractures. T…
View article: Parameter estimation in fluid flow models from aliased velocity measurements
Parameter estimation in fluid flow models from aliased velocity measurements Open
Parameter estimation in blood flow models from measured velocity data—as e.g. velocity-encoded MRI—is a key step for patient-specific hemodynamic analysis. However, velocity encoding suffers from competing noise and aliasing artifacts, whi…
View article: Monitoring Fracture Saturation With Internal Seismic Sources and Twin Neural Networks
Monitoring Fracture Saturation With Internal Seismic Sources and Twin Neural Networks Open
Seismic coda‐wave analysis is a well‐developed method for detecting subtle physical changes in complex media by measuring arrival times in the late‐arriving energy from multiply scattered or reflected waves. However, a challenge arises whe…
View article: Data for Monitoring Fracture Saturation with Internal Transportable Seismic Sources and Twin Neural Networks
Data for Monitoring Fracture Saturation with Internal Transportable Seismic Sources and Twin Neural Networks Open
Seismic coda-wave analysis is a well-developed method for detecting subtle physical changes in complex media by measuring arrival times in the late-arriving energy from multiply-scattered or reflected waves. However, a challenge arises whe…
View article: Cancer Holography for Personalized Medicine
Cancer Holography for Personalized Medicine Open
Digital holography can measure the 3D physiology and motion of cancer cells, allowing identification of effective chemotherapies for patients.
View article: Error analysis of pressure reconstruction from discrete velocities
Error analysis of pressure reconstruction from discrete velocities Open
Magnetic Resonance Imaging allows to measure the three-dimensional velocity field in blood flows. There- fore, several methods have been proposed to reconstruct the pressure field from such measurements using the incompressible Navier-Stok…
View article: Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues
Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues Open
A common-path interferometer using a grating and an SF can provide enhanced interferometric stability in tissue-dynamics spectroscopy for drug screening assays.
View article: Doppler imaging detects bacterial infection of living tissue
Doppler imaging detects bacterial infection of living tissue Open
Living 3D in vitro tissue cultures, grown from immortalized cell lines, act as living sentinels as pathogenic bacteria invade the tissue. The infection is reported through changes in the intracellular dynamics of the sentinel cells caused …
View article: Biodynamic signatures from ex vivo bone marrow aspirates are associated with chemotherapy‐induced neutropenia in cancer‐bearing dogs
Biodynamic signatures from ex vivo bone marrow aspirates are associated with chemotherapy‐induced neutropenia in cancer‐bearing dogs Open
Background Neutropenia is the most common dose‐limiting side effect of cytotoxic chemotherapy in cancer‐bearing dogs. Biodynamic imaging (BDI) is a functional imaging technology that measures dynamic light scattering from living, three‐dim…
View article: Biodynamic digital holographic speckle microscopy for oocyte and embryo metabolic evaluation
Biodynamic digital holographic speckle microscopy for oocyte and embryo metabolic evaluation Open
Assisted reproductive technologies seek to improve the success rate of pregnancies. Morphology scoring is a common approach to evaluate oocyte and embryo viability prior to embryo transfer in utero , but the efficacy of the method is low. …
View article: Probing complex geophysical geometries with chattering dust
Probing complex geophysical geometries with chattering dust Open
The modern energy economy and environmental infrastructure rely on the flow of fluids through fractures in rock. Yet this flow cannot be imaged directly because rocks are opaque to most probes. Here we apply chattering dust, or chemically …
View article: Tissue Dynamics Spectroscopic Imaging: Functional Imaging of Heterogeneous Cancer Tissue
Tissue Dynamics Spectroscopic Imaging: Functional Imaging of Heterogeneous Cancer Tissue Open
Significance Tumor heterogeneity poses a challenge for the chemotherapeutic treatment of cancer. Tissue dynamics spectroscopy (TDS) captures dynamic contrast and can capture the response of living tissue to applied therapeutics, but the cu…
View article: Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue
Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue Open
We have demonstrated the utility of TDSI as a functional imaging method to measure tumor heterogeneity and its potential for use in drug-response profiling.
View article: Intracellular Optical Doppler Phenotypes of Chemosensitivity in Human Epithelial Ovarian Cancer
Intracellular Optical Doppler Phenotypes of Chemosensitivity in Human Epithelial Ovarian Cancer Open
Development of an assay to predict response to chemotherapy has remained an elusive goal in cancer research. We report a phenotypic chemosensitivity assay for epithelial ovarian cancer based on Doppler spectroscopy of infrared light scatte…
View article: Integration of Biodynamic Imaging and RNA-seq classifies chemotherapy response in canine diffuse large B-cell lymphoma
Integration of Biodynamic Imaging and RNA-seq classifies chemotherapy response in canine diffuse large B-cell lymphoma Open
Diffuse large B-cell lymphoma (DLBCL) is a common, aggressive cancer of notorious genotypic and phenotypic heterogeneity. A major challenge is predicting response to drug treatment, which has typically been done using genomic tools alone w…