Denisa Ondruskova
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View article: An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule stabilizing sites
An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule stabilizing sites Open
Microtubules (MTs) are essential cytoskeletal polymers with dual functions: they generate mechanical forces necessary for processes such as mitosis and angiogenesis, and serve as static tracks for intracellular transport by motor proteins.…
View article: Dissecting structural and functional determinants of microtubule stabilization through guided chemical modulation
Dissecting structural and functional determinants of microtubule stabilization through guided chemical modulation Open
Paclitaxel (PTX) is a widely used chemotherapeutic, but its efficacy is limited by peripheral neuropathy, likely due to its structural impact on neuronal microtubules (MTs). To decouple MT stabilization from adverse structural changes, we …
View article: Tubulin isotypes polymerise into sectioned microtubules that locally regulate protein binding
Tubulin isotypes polymerise into sectioned microtubules that locally regulate protein binding Open
Microtubules assemble from tubulin heterodimers composed of conserved α- and β- tubulins. In many species, including humans, tubulins are expressed from multiple genes. While the resulting tubulin isotypes show only subtle sequence differe…