David Navarro
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View article: Community-acquired respiratory virus infections in patients with haematological malignancies or undergoing haematopoietic cell transplantation: updated recommendations from the 10th European Conference on Infections in Leukaemia
Community-acquired respiratory virus infections in patients with haematological malignancies or undergoing haematopoietic cell transplantation: updated recommendations from the 10th European Conference on Infections in Leukaemia Open
To update recommendations of the 4th European Conference on Infections in Leukaemia (ECIL-4) on community-acquired respiratory virus (CARV) infections published in 2013, we reviewed publications from between Jan 1, 2014, and June 30, 2024 …
View article: Dynamics of SARS‐CoV‐2 Spike Receptor‐Binding Domain‐Targeted Specific Peripheral Memory B Cells in Patients With End‐Stage Chronic Kidney Disease Undergoing Replacement Therapy Following COVID‐19 Vaccination
Dynamics of SARS‐CoV‐2 Spike Receptor‐Binding Domain‐Targeted Specific Peripheral Memory B Cells in Patients With End‐Stage Chronic Kidney Disease Undergoing Replacement Therapy Following COVID‐19 Vaccination Open
Memory B cells (MBCs) are responsible for maintaining long‐lasting functional B‐cell immune responses. Little is known about the kinetics of peripheral blood (PB) SARS‐CoV‐2 vaccine‐induced MBCs in end‐stage chronic kidney disease (CKD) pa…
View article: Virus Detection by CRISPR-Cas9-Mediated Strand Displacement in a Lateral Flow Assay
Virus Detection by CRISPR-Cas9-Mediated Strand Displacement in a Lateral Flow Assay Open
In public health emergencies or in resource-constrained settings, laboratory-based diagnostic methods, such as RT-qPCR, need to be complemented with accurate, rapid, and accessible approaches to increase testing capacity, as this will tran…
View article: Evaluation of the VIDAS Cytomegalovirus (CMV)‐IGRA for Assessing CMV‐Specific T‐Cell Responses in Immunocompetent and Immunosuppressed Individuals
Evaluation of the VIDAS Cytomegalovirus (CMV)‐IGRA for Assessing CMV‐Specific T‐Cell Responses in Immunocompetent and Immunosuppressed Individuals Open
We compared the performance of the VIDAS Cytomegalovirus (CMV)‐Interferon‐gamma release assay (IGRA) with that of laboratory‐developed flow cytometry for intracellular cytokine staining (FC‐ICS) for the assessment of CMV‐specific interfero…
View article: Virus detection by CRISPR-Cas9-mediated strand displacement in a lateral flow assay
Virus detection by CRISPR-Cas9-mediated strand displacement in a lateral flow assay Open
In public health emergencies or in resource-constrained settings, laboratory-based diagnostic methods, such as RT-qPCR, need to be complemented with accurate, rapid, and accessible approaches to increase testing capacity, as this will tran…
View article: Estimating SARS‐CoV‐2 Omicron XBB.1.5 Spike‐Directed Functional Antibody Levels From an Anti‐Receptor Binding Domain Wuhan‐Hu‐1‐Based Commercial Immunoassay Results
Estimating SARS‐CoV‐2 Omicron XBB.1.5 Spike‐Directed Functional Antibody Levels From an Anti‐Receptor Binding Domain Wuhan‐Hu‐1‐Based Commercial Immunoassay Results Open
We investigated whether antibody concentrations measured in plasma using the Roche Elecsys® Anti‐SARS‐CoV‐2 S assay (targeting the receptor binding domain, RBD) could estimate levels of Wuhan‐Hu‐1 and Omicron XBB.1.5 spike‐directed antibod…
View article: The role of rapid multiplex molecular syndromic panels in the clinical management of infections in critically ill patients: an experts-opinion document
The role of rapid multiplex molecular syndromic panels in the clinical management of infections in critically ill patients: an experts-opinion document Open
Rapid multiplex molecular syndromic panels (RMMSP) (3 or more pathogens and time-to-results < 6 h) allow simultaneous detection of multiple pathogens and genotypic resistance markers. Their implementation has revolutionized the clinical la…
View article: Cytomegalovirus DNA doubling time for early identification of clinically significant infection episodes in allogeneic hematopoietic stem cell transplant recipients undergoing primary Letermovir prophylaxis: A multicenter study
Cytomegalovirus DNA doubling time for early identification of clinically significant infection episodes in allogeneic hematopoietic stem cell transplant recipients undergoing primary Letermovir prophylaxis: A multicenter study Open
We evaluated the potential of Cytomegalovirus (CMV) DNA doubling time (dt) in plasma to distinguish between clinically significant CMV infection (CsCMVi) and abortive CMV infection in allogeneic hematopoietic stem cell transplant (allo-HSC…
View article: New Insights into Mucosa-Associated Microbiota in Paired Tumor and Non-Tumor Adjacent Mucosal Tissues in Colorectal Cancer Patients
New Insights into Mucosa-Associated Microbiota in Paired Tumor and Non-Tumor Adjacent Mucosal Tissues in Colorectal Cancer Patients Open
Background/Objective: Colorectal cancer (CRC) is one of the most common cancers worldwide. Increasing scientific evidence supports the idea that gut microbiota dysbiosis accompanies colorectal tumorigenesis, and these changes could be caus…
View article: Ventilator-associated lower respiratory tract infections and bacteremia in medical and surgical critical care patients colonized by multidrug-resistant bacteria
Ventilator-associated lower respiratory tract infections and bacteremia in medical and surgical critical care patients colonized by multidrug-resistant bacteria Open
Purpose: We investigated the risk of bloodstream infections (BSI) and ventilator-associated lower respiratory tract (LRT) infections, including pneumonia (VAP) and tracheobronchitis (VAT), due to multidrug-resistant bacteria (MDRB) in colo…
View article: UPDATE ON CYTOMEGALOVIRUS INFECTION MANAGEMENT IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS.
UPDATE ON CYTOMEGALOVIRUS INFECTION MANAGEMENT IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS. Open
Background: Cytomegalovirus (CMV) infection is a common complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and in patients receiving novel hematological therapies. Its impact on morbidity and mortality ne…
View article: Time to Positivity of Coagulase Negative Staphylococcus in Neonatal Blood Cultures as a Useful Tool to Discriminate Between Sepsis and Contamination
Time to Positivity of Coagulase Negative Staphylococcus in Neonatal Blood Cultures as a Useful Tool to Discriminate Between Sepsis and Contamination Open
Objective: to assess the usefulness of time to positivity (TTP) to distinguish between sepsis and contamination in coagulase-negative staphylococci (CoNS) isolates. Study design: unicentric retrospective observational. 168 patients with s…
View article: Abbott realtime MTB assay for detecting Mycobacterium tuberculosis complex in respiratory specimens: a cost-benefit analysis
Abbott realtime MTB assay for detecting Mycobacterium tuberculosis complex in respiratory specimens: a cost-benefit analysis Open
Employing PCR as an MTB screening method in a low-prevalence setting may increase the profits to the system.
View article: SARS‐CoV‐2‐Spike T‐cell response after receiving one or two Wuhan‐Hu‐1‐based mRNA COVID‐19 vaccine booster doses in elderly nursing home residents
SARS‐CoV‐2‐Spike T‐cell response after receiving one or two Wuhan‐Hu‐1‐based mRNA COVID‐19 vaccine booster doses in elderly nursing home residents Open
The effect of COVID‐19 booster vaccination on SARS‐CoV‐2 T‐cell mediated immune responses in elderly nursing home residents has not been explored in depth. Thirty‐nine elderly nursing home residents (median age, 91 years) were included, al…
View article: Comparative performance of the Platelia <i>Aspergillus</i> Antigen and <i>Aspergillus</i> Galactomannan antigen Virclia Monotest immunoassays in serum and lower respiratory tract specimens: a “real-life” experience
Comparative performance of the Platelia <i>Aspergillus</i> Antigen and <i>Aspergillus</i> Galactomannan antigen Virclia Monotest immunoassays in serum and lower respiratory tract specimens: a “real-life” experience Open
The Platelia Aspergillus Antigen immunoassay is the “gold standard” for Aspergillus galactomannan (GLM) measurement in sera and bronchoalveolar lavage (BAL) for the diagnosis of invasive pulmonary aspergillosis (IPA). We evaluated the perf…
View article: The <i>ethylene‐responsive transcription factor ERF024</i> is a novel regulator of climacteric fruit ripening in melon
The <i>ethylene‐responsive transcription factor ERF024</i> is a novel regulator of climacteric fruit ripening in melon Open
SUMMARY Fruit ripening is an essential developmental stage in Angiosperms triggered by hormonal signals such as ethylene, a major player in climacteric ripening. Melon is a unique crop showing both climacteric and non‐climacteric cultivars…
View article: Performance evaluation of the Alinity m system for quantifying cytomegalovirus DNA in samples of the respiratory, gastrointestinal, and urinary tract
Performance evaluation of the Alinity m system for quantifying cytomegalovirus DNA in samples of the respiratory, gastrointestinal, and urinary tract Open
Quantitation of cytomegalovirus (CMV) DNA load in specimens other than blood such as bronchoalveolar lavages, intestinal biopsies, or urine has become a common practice as an ancillary tool for the diagnosis of CMV pneumonitis, intestinal …
View article: Impact of Long SARS-CoV-2 Omicron Infection on the Health Care Burden: Comparative Case-Control Study Between Omicron and Pre-Omicron Waves
Impact of Long SARS-CoV-2 Omicron Infection on the Health Care Burden: Comparative Case-Control Study Between Omicron and Pre-Omicron Waves Open
Background Following the initial acute phase of COVID-19, health care resource use has escalated among individuals with SARS-CoV-2 infection. Objective This study aimed to compare new diagnoses of long COVID and the demand for health servi…