Paul Piehowski
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View article: Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19
Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19 Open
Post-Acute Sequelae of COVID-19 (PASC), or "long COVID," describes persistent symptoms following recovery from SARS-CoV-2 infection. Early identification of circulating biomarkers predictive of PASC is critical for prognosis and therapeuti…
View article: Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region
Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region Open
[This corrects the article DOI: 10.1371/journal.pone.0250586.].
View article: spammR: an R package designed for analysis and integration of spatial multi-omic measurements
spammR: an R package designed for analysis and integration of spatial multi-omic measurements Open
Summary Spatial omics is a young and evolving field and as such shows rapid development of novel technologies and analysis methods to measure transcripts, proteins, metabolites, and post-translational modifications at high spatial resoluti…
View article: Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults
Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults Open
Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), yet the underlying molecular mediators remain poorly understood. Here, leveraging ASAT tr…
View article: Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants
Integrated lipidomic and proteomic profiling reveals metabolic network disruption by SARS-CoV-2 variants Open
The rapid evolution of SARS-CoV-2 has produced myriad viral strains with increasing transmissibility and capacity for immune evasion. While effective vaccination campaigns have reduced the fatalities associated with SARS-CoV-2, infections …
View article: Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection
Multi-Omic Profiling Identifies Conserved Metabolic Pathways Critical for SARS-CoV-2 Variants Infection Open
The rapid evolution of SARS-CoV-2 has led to the emergence of numerous variants with en-hanced transmissibility and immune evasion. Despite widespread vaccination, infections persist, and the mechanisms by which SARS-CoV-2 reprograms host …
View article: Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors
Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Open
The LC-MS raw datasets that support the findings of this study have been deposited in the online repository: MassIVE ( https://massive.ucsd.edu/ProteoSAFe/static/massive.jsp ) with accession no. MSV000090212.
View article: Oncogenic <i>NTRK3</i> mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia
Oncogenic <i>NTRK3</i> mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia Open
Not available.
View article: Exercise alters molecular profiles of inflammation and substrate metabolism in human white adipose tissue
Exercise alters molecular profiles of inflammation and substrate metabolism in human white adipose tissue Open
This is the first study to utilize a multiomic (RNAseq, proteomics, and phosphoproteomics) approach to investigate molecular adaptations in WAT after a short-term intervention in sedentary overweight women. We show that supervised aerobic …
View article: Standardized and accessible multi-omics bioinformatics workflows through the NMDC EDGE resource
Standardized and accessible multi-omics bioinformatics workflows through the NMDC EDGE resource Open
Accessible and easy-to-use standardized bioinformatics workflows are necessary to advance microbiome research from observational studies to large-scale, data-driven approaches. Standardized multi-omics data enables comparative studies, dat…
View article: Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases
Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases Open
Aims/hypothesis Progression to type 1 diabetes (T1D) is associated with genetic factors, the presence of autoantibodies, and a decline in β cell insulin secretion in response to glucose. Very little is known regarding the molecular changes…
View article: Coupling Microdroplet-Based Sample Preparation, Multiplexed Isobaric Labeling, and Nanoflow Peptide Fractionation for Deep Proteome Profiling of the Tissue Microenvironment
Coupling Microdroplet-Based Sample Preparation, Multiplexed Isobaric Labeling, and Nanoflow Peptide Fractionation for Deep Proteome Profiling of the Tissue Microenvironment Open
There is increasing interest in developing in-depth proteomic approaches for mapping tissue heterogeneity in a cell-type-specific manner to better understand and predict the function of complex biological systems such as human organs. Exis…
View article: Suppl Table S8 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Suppl Table S8 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia Open
GSEA analysis from trametinib-sensitive and resistant cells
View article: Supp Table S1 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Supp Table S1 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia Open
Cytokine levels in patient samples
View article: Suppl Table S5 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Suppl Table S5 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia Open
AML feature annotations
View article: Star Table 1 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Star Table 1 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia Open
Resource Table
View article: Suppl Table S7 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Suppl Table S7 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia Open
Phosphopeptides identified by trametinib and CCL2 treatments using a KSEA analysis
View article: Supp Table S3 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Supp Table S3 from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia Open
RNA-seq gene list and pathway correlation with drug resistance
View article: Data from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia
Data from Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia Open
Purpose:Emerging evidence underscores the critical role of extrinsic factors within the microenvironment in protecting leukemia cells from therapeutic interventions, driving disease progression, and promoting drug resistance in acute myelo…