David R. Webb
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View article: The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study
The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study Open
Introduction Roux-en-Y gastric bypass (RYGB) induces substantial weight loss and changes in glucose homeostasis, partly through alterations in gastrointestinal anatomy and nutrient absorption. Sodium-glucose co-transporters-1 (SGLT-1) faci…
View article: Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network
Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network Open
The five-year risk of cancer was higher in those with newly diagnosed type 2 diabetes versus those without. Absolute risk was greater in middle-older age adults, although relative rates were greater amongst younger adults. This persisted a…
View article: 6-023 Is skeletal myosteatosis independently associated with exercise capacity in asymptomatic people with type 2 diabetes?
6-023 Is skeletal myosteatosis independently associated with exercise capacity in asymptomatic people with type 2 diabetes? Open
View article: Foot Measurements From Three‐Dimensional Scans: Elinvision 3DST Reliability
Foot Measurements From Three‐Dimensional Scans: Elinvision 3DST Reliability Open
Background 3D foot scanners such as the Elinvision 3DST foot scanner potentially offer a faster, alternative method to traditional plaster casting to produce orthotics or therapeutic footwear. Objective(s) To assess the reliability of 3DST…
View article: Outcomes of Different Lifestyle Approaches in a Multicentre, Open-Label, Parallel-Group, Randomised Controlled Trial of the Effectiveness of Integrating a Pragmatic Pathway for Prescribing Liraglutide 3.0 mg in Weight Management Services (STRIVE Study)
Outcomes of Different Lifestyle Approaches in a Multicentre, Open-Label, Parallel-Group, Randomised Controlled Trial of the Effectiveness of Integrating a Pragmatic Pathway for Prescribing Liraglutide 3.0 mg in Weight Management Services (STRIVE Study) Open
Background/Objectives: The STRIVE study was a multicentre, open-label, real-world clinical trial evaluating the effectiveness of a targeted prescribing pathway for liraglutide 3.0 mg as an adjunct to standard care versus standard care alon…
View article: The use of <scp>SGLT2</scp> inhibitors in people with diabetes‐related foot disease: A Delphi‐based consensus study
The use of <span>SGLT2</span> inhibitors in people with diabetes‐related foot disease: A Delphi‐based consensus study Open
Aims To generate expert consensus‐based clinical recommendations on the use of SGLT2 inhibitors in those with diabetes and diabetes‐related foot disease (DFD). Materials and Methods This study employed a two‐round online Delphi technique. …
View article: A multifactorial intervention to improve cardiovascular outcomes in adults with type 2 diabetes and current or previous diabetic foot ulcer disease: Protocol for a multi‐centre randomised control trial ( <scp>MiFoot</scp> study)
A multifactorial intervention to improve cardiovascular outcomes in adults with type 2 diabetes and current or previous diabetic foot ulcer disease: Protocol for a multi‐centre randomised control trial ( <span>MiFoot</span> study) Open
Background In the United Kingdom, the prevalence of diabetes‐related foot ulcer disease (DFUD) is 6.3%, and cardiovascular disease (CVD) is the leading cause of mortality in people with DFUD. This study aims to evaluate the effectiveness o…
View article: Time to act? Is the new era of gut hormone-based pharmacotherapy an opportunity to rethink the tier-based UK obesity care model?
Time to act? Is the new era of gut hormone-based pharmacotherapy an opportunity to rethink the tier-based UK obesity care model? Open
Obesity, like type 2 diabetes, is a complex, often life limiting disease influenced by genetics and modern environment. However, unlike diabetes, the provision of integrated, holistic care for people with obesity in the UK remains underdev…
View article: Treatment patterns and burden of uncomplicated urinary tract infection in England: a retrospective cohort study
Treatment patterns and burden of uncomplicated urinary tract infection in England: a retrospective cohort study Open
Background Uncomplicated urinary tract infections (uUTIs) are common bacterial infections. Aim To evaluate the burden of uUTI in England for 1) potential determinants of disease progression; 2) extent and impact of antimicrobial prescribin…
View article: Adipocyte endothelin B receptor activation inhibits adiponectin production and causes insulin resistance in obese mice
Adipocyte endothelin B receptor activation inhibits adiponectin production and causes insulin resistance in obese mice Open
Aims Endothelin‐1 (ET‐1) is elevated in patients with obesity and adipose tissue of obese mice fed high‐fat diet (HFD); however, its contribution to the pathophysiology of obesity is not fully understood. Genetic loss of endothelin type B …
View article: Capturing How the Accelerometer Measured Physical Activity Profile Differs in People with Diabetic Foot Ulceration
Capturing How the Accelerometer Measured Physical Activity Profile Differs in People with Diabetic Foot Ulceration Open
Diabetic Foot Ulcers (DFUs) are a major complication of diabetes, with treatment requiring offloading. This study aimed to capture how the accelerometer-assessed physical activity profile differs in those with DFUs compared to those with d…
View article: Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training
Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training Open
Aims To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials and Methods In Part A (cross‐secti…
View article: Non-pharmacological interventions to improve cardiovascular risk factors in people with diabetic foot disease: A systematic review and meta-analysis
Non-pharmacological interventions to improve cardiovascular risk factors in people with diabetic foot disease: A systematic review and meta-analysis Open
Cardiovascular disease (CVD) risk in those with diabetic foot disease is very high. Non-pharmacological interventions may improve this risk, though no previous evidence synthesis has been completed. This systematic review aimed to investig…
View article: Do maternal haemodynamics have a causal influence on treatment for gestational diabetes?
Do maternal haemodynamics have a causal influence on treatment for gestational diabetes? Open
Maternal BMI at booking has a causal, rather than simply associational, relationship on the need for pharmacological treatment of GDM. No significant causal relationships were found between maternal haemodynamics and the need for pharmacol…
View article: Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial
Effectiveness of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in weight management services (STRIVE study): a multicentre, open-label, parallel-group, randomized controlled trial Open
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View article: Age at Type 2 Diabetes Diagnosis and Risk of Cancer: Cohort Study in Over 1 Million Individuals from the TriNetX US Collaborative Network
Age at Type 2 Diabetes Diagnosis and Risk of Cancer: Cohort Study in Over 1 Million Individuals from the TriNetX US Collaborative Network Open
View article: Impact of weight loss and weight gain trajectories on body composition in a population at high risk of type 2 diabetes: A prospective cohort analysis
Impact of weight loss and weight gain trajectories on body composition in a population at high risk of type 2 diabetes: A prospective cohort analysis Open
Aim In a primary care population at high risk of type 2 diabetes, 24‐month weight change trajectories were used to investigate the impact of weight cycling on fat mass (FM) and fat‐free mass (FFM). Materials and Methods Cohort data from th…
View article: UK Kidney Association Clinical Practice Guideline: Sodium-Glucose Co-transporter-2 (SGLT-2) Inhibition in Adults with Kidney Disease 2023 UPDATE
UK Kidney Association Clinical Practice Guideline: Sodium-Glucose Co-transporter-2 (SGLT-2) Inhibition in Adults with Kidney Disease 2023 UPDATE Open
Large placebo-controlled trials have demonstrated kidney and cardiovascular clinical benefits of SGLT-2 inhibitors. Data from the EMPA-KIDNEY and DELIVER trials and associated meta-analyses triggered an update to the UK Kidney Association …
View article: Effect of delay in treatment intensification in people with type 2 diabetes and suboptimal glycaemia after basal insulin initiation: A real‐world observational study
Effect of delay in treatment intensification in people with type 2 diabetes and suboptimal glycaemia after basal insulin initiation: A real‐world observational study Open
Aim Despite global recommendations for type 2 diabetes mellitus treatment to maintain optimal glycaemic targets, a significant proportion of people remain in suboptimal glycaemic control. Our objective was to investigate the impact of inte…
View article: Factors associated with therapeutic inertia in individuals with type 2 diabetes mellitus started on basal insulin
Factors associated with therapeutic inertia in individuals with type 2 diabetes mellitus started on basal insulin Open
Therapeutic inertia still remains a major barrier, with multiple factors associated with delay in intensification. Interventions to overcome therapeutic inertia need to be implemented at both patient and health care professional level.
View article: P19 Burden of illness and costs among female patients with uncomplicated urinary tract infection in England
P19 Burden of illness and costs among female patients with uncomplicated urinary tract infection in England Open
Background and Objectives Uncomplicated urinary tract infection (uUTI) is usually community-acquired. Data regarding the wider burden of illness from uUTI are scarce. We evaluated the burden of uUTI in female patients in England. Methods T…
View article: P18 Treatment patterns and extent of inappropriate antimicrobial treatment among female patients with uncomplicated urinary tract infection in England
P18 Treatment patterns and extent of inappropriate antimicrobial treatment among female patients with uncomplicated urinary tract infection in England Open
Background and Objectives Inappropriate antimicrobial treatment of uncomplicated urinary tract infection (uUTI) has potential impacts on healthcare resource use and costs. We characterized treatment patterns for uUTI in England, including …
View article: Hotspots: Adherence in home foot temperature monitoring interventions for at‐risk feet with diabetes—A narrative review
Hotspots: Adherence in home foot temperature monitoring interventions for at‐risk feet with diabetes—A narrative review Open
Background Home foot temperature monitoring (HFTM) is recommended for those at moderate to high ulcer risk. Where a > 2.2°C difference in temperature between feet (hotspot) is detected, it is suggested that individuals (1) notify a healthc…
View article: Factors associated with therapeutic inertia in individuals with type 2 diabetes mellitus started on basal insulin
Factors associated with therapeutic inertia in individuals with type 2 diabetes mellitus started on basal insulin Open
Aim In this study we aim to identify the risk factors for treatment inertia in patients with type 2 diabetes mellitus (T2DM) who have been recently started on basal insulin (BI). Methods Using UK CPRD GOLD, we identified adults with T2DM w…
View article: PCNL in neurogenic bladder: A challenging population for both clinical management and analysis
PCNL in neurogenic bladder: A challenging population for both clinical management and analysis Open
Objectives To review the management of patients with neurogenic bladder undergoing percutaneous nephrolithotomy (PCNL) at our institution with the aim of assessing peri‐operative morbidity. Subjects/patients and methods We conducted a retr…
View article: Cancer is becoming the leading cause of death in diabetes – Authors' reply
Cancer is becoming the leading cause of death in diabetes – Authors' reply Open
View article: Impact of novel glucose‐lowering therapies on physical function in people with type 2 diabetes: A systematic review and meta‐analysis of randomised placebo‐controlled trials
Impact of novel glucose‐lowering therapies on physical function in people with type 2 diabetes: A systematic review and meta‐analysis of randomised placebo‐controlled trials Open
Aims We investigated evidence from randomised, placebo‐controlled trials of novel glucose‐lowering therapies; sodium‐glucose co‐transporter‐2 inhibitors (SGLT2i), dipeptidyl peptidase‐4 inhibitors (DPP4i) and glucagon‐like peptide‐1 recept…
View article: IDF2022-0579 Post COVID-19 diabetes project: Intensive cardio-renal-metabolic management for people living with type 2 diabetes (T2D)
IDF2022-0579 Post COVID-19 diabetes project: Intensive cardio-renal-metabolic management for people living with type 2 diabetes (T2D) Open
View article: The effects of weight‐lowering pharmacotherapies on physical activity, function and fitness: A systematic review and meta‐analysis of randomized controlled trials
The effects of weight‐lowering pharmacotherapies on physical activity, function and fitness: A systematic review and meta‐analysis of randomized controlled trials Open
Summary Weight‐lowering pharmacotherapies provide an option for weight management; however, their effects on physical activity, function, and cardiorespiratory fitness are not fully understood. We conducted a systematic review and meta‐ana…
View article: The effect of acute and chronic exercise on hepatic lipid composition
The effect of acute and chronic exercise on hepatic lipid composition Open
Exercise is recommended for those with, or at risk of nonalcoholic fatty liver disease (NAFLD), owing to beneficial effects on hepatic steatosis and cardiometabolic risk. Whilst exercise training reduces total intrahepatic lipid in people …