Deepak A. Rao
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View article: Single Cell Analysis of pBMCs of Psoriasis patients reveals distinct CD4+ T cell phenotypes associated with response to IL-23 blockade
Single Cell Analysis of pBMCs of Psoriasis patients reveals distinct CD4+ T cell phenotypes associated with response to IL-23 blockade Open
The use of IL-23 inhibitors (IL-23i) for psoriatic diseases has resulted in significant improvement in disease symptoms for many patients. The extent of disease improvement following IL-23 blockade varies across patients with psoriasis; ho…
View article: Spatial Transcriptomics Identify T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis
Spatial Transcriptomics Identify T Cell-Driven Mechanisms of Kidney Damage in Immune Checkpoint Inhibitor-Associated Acute Interstitial Nephritis Open
Introduction: Immune checkpoint inhibitor-associated acute interstitial nephritis (ICI-AIN) is the most common finding on histopathology among patients with ICI-associated acute kidney injury (ICI-AKI). Patients with ICI-AIN often have T c…
View article: PD-1 expressing B cells are expanded in lupus 4452
PD-1 expressing B cells are expanded in lupus 4452 Open
Description Lupus is a complex autoimmune disease that involves dysregulation of the B cell compartment. Potential mechanisms for this dysregulation include abnormalities in immune dampening pathways, such as the programmed cell death 1 re…
View article: Pre-treatment naïve T cells are associated with severe irAE following PD-1/CTLA4 checkpoint blockade for melanoma
Pre-treatment naïve T cells are associated with severe irAE following PD-1/CTLA4 checkpoint blockade for melanoma Open
Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-CTLA-4 antibodies are used to induce an immune response against many types of tumors. However, ICIs often also induce autoimmune responses, referred to as immune-related advers…
View article: Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment
Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment Open
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of h…
View article: Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases
Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases Open
Regulatory T cells (Tregs), characterized by FOXP3 expression, are essential for maintaining immune homeostasis by controlling inflammation. However, in autoimmune diseases such as rheumatoid arthritis (RA), impaired Treg function contribu…
View article: A phase 1 randomized, placebo-controlled trial of a combination typhoid and non-typhoidal <i>Salmonella</i> polysaccharide conjugate vaccine
A phase 1 randomized, placebo-controlled trial of a combination typhoid and non-typhoidal <i>Salmonella</i> polysaccharide conjugate vaccine Open
In sub-Saharan Africa, non-typhoidal Salmonella (NTS) and Salmonella Typhi are leading causes of invasive disease among young children. Trivalent Salmonella Conjugate Vaccine (TSCV) consists of Vi capsule polysaccharide conjugated to tetan…
View article: A population-scale atlas of blood and tissue in lupus nephritis
A population-scale atlas of blood and tissue in lupus nephritis Open
Lupus nephritis (LN), a severe manifestation of Systemic lupus erythematosus (SLE), is a heterogeneous disease driven by diverse immune and tissue cell types. Current treatments of LN are non-specific, increase risk of infection, and have …
View article: Neutrophil Heterogeneity Identifies an Association of LAMP1 With Proliferative Lupus Nephritis
Neutrophil Heterogeneity Identifies an Association of LAMP1 With Proliferative Lupus Nephritis Open
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) with limited biomarkers for early detection. While neutrophils contribute to SLE pathogenesis, their phenotypic heterogeneity in disease remains poorly ch…
View article: Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis
Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis Open
Lupus nephritis (LN) is a frequent manifestation of systemic lupus erythematosus, and fewer than half of patients achieve complete renal response with standard immunosuppressants. Identifying noninvasive, blood-based immune alterations ass…
View article: Maternal Outcomes Following Emergency Cesarean Delivery: Evaluating the Enhanced Recovery After Surgery Protocol in a Randomized Controlled Trial
Maternal Outcomes Following Emergency Cesarean Delivery: Evaluating the Enhanced Recovery After Surgery Protocol in a Randomized Controlled Trial Open
A BSTRACT Aim: To evaluate the impact of the enhanced recovery after surgery (ERAS) protocol on maternal outcomes following emergency cesarean delivery (CD). Materials and Methods: The study was conducted at ACS Medical College and Hospita…
View article: P113 Cellular profiling of synovial fluid in inflammatory arthritis highlights disease-specific cell states with biological and diagnostic relevance
P113 Cellular profiling of synovial fluid in inflammatory arthritis highlights disease-specific cell states with biological and diagnostic relevance Open
Background/Aims Rheumatoid arthritis (RA) is characterised by synovial inflammation where CD4+ T cells are central mediators of autoimmune pathology. On the other hand, spondyloarthropathies are believed to be driven by CD8+ T cells. Patho…
View article: Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a systemic autoimmune disease currently with no universally highly effective prevention strategies. Identifying pathogenic immune phenotypes in at-risk populations prior to clinical onset is crucial to establis…
View article: Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus
Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus Open
Pathologic T cell-B cell interactions drive disease in systemic lupus erythematosus (SLE). The T cells that activate B cell responses include T peripheral helper (Tph) and T follicular helper (Tfh) cells, yet the developmental and clonal r…
View article: A CD57+ cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis
A CD57+ cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis Open
Interstitial lung disease (ILD) is a major cause of morbidity and mortality in systemic sclerosis (SSc); however, the immunopathologic mechanisms driving lung disease in SSc are unclear. T cells have been implicated as a likely driver of l…
View article: A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis
A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis Open
Systemic sclerosis (SSc) is immune-mediate inflammatory disease characterized by progressive tissue fibrosis. We observed that circulating neutrophils from patients with diffuse SSc exhibit an activated phenotype, a finding echoed in blood…
View article: Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis Open
Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform …
View article: Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis
Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis Open
Objectives To evaluate urinary activated leucocyte cell adhesion molecule (ALCAM) and CD6 as predictors of LN progression or disease resolution across a 1-year study. Methods Serum and urine samples from biopsy proven LN subjects (n = 122)…
View article: Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium Open
Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identi…