Deborah M. Roll
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Synthesis of Phosphatidylinositol 3-Kinase (PI3K) Inhibitory Analogues of the Sponge Meroterpenoid Liphagal Open
Analogues of the sponge meroterpenoid liphagal have been synthesized and evaluated for inhibition of PI3Kα and PI3Kγ as part of a program aimed at developing new isoform-selective PI3K inhibitors. One of the analogues, compound 24, with IC…
Fermentative production of self-toxic fungal secondary metabolites Open
Fungi are well known for their vast diversity of secondary metabolites that include many life-saving drugs and highly toxic mycotoxins. In general, fungal cultures producing such metabolites are immune to their toxic effects. However, some…
The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus <i>Verticillium lecanii</i> 6144 Open
Four new indolosesquiterpenes, lecanindoles A-D (1-4), were isolated from fermentations of the terrestrial fungus Verticillium lecanii 6144. The structures of compounds 1-4 were elucidated from analysis of spectroscopic data. Compound 2 wa…
Phaeosphaeride A, an Inhibitor of STAT3‐Dependent Signaling Isolated from an Endophytic Fungus. Open
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Phaeosphaeride A, an Inhibitor of STAT3-Dependent Signaling Isolated from an Endophytic Fungus Open
Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.
Liphagal, a Selective Inhibitor of PI3 Kinase α Isolated from the Sponge Aka coralliphaga: Structure Elucidation and Biomimetic Synthesis. Open
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Absolute stereochemistry of unusual biopolymers fromAscomycete culture LL-W1278: Examples that derivatives of (S)-6-hydroxymellein are also natural fungal metabolites Open
The new linear polyesters, W1278-A, B, and C, were isolated from culture extracts of a freshwater Ascomycete fungus. Their structures were elucidated on the basis of spectroscopic analyses and chemical transformations, with the absolute co…
The Structure of V214w From an Unidentified Fungus. Open
While searching for novel biological activity during a recent reevaluation of samples from our Antibiotic Collection, we isolated the known antibiotic 6-epi-5'hydroxy-mycosporulone (1)1) from culture V214, an unidentified mitosporic fungus…
Hongoquercins A and B, New Sesquiterpenoid Antibiotics: Isolation, Structure Elucidation, and Antibacterial Activity. Open
Two new sesquiterpenoid antibiotics, hongoquercins A and B, were isolated from the extracts of an unidentified fungus. The structures of both metabolites were determined by spectroscopic analysis. They are related to a class of compounds c…