David S. Schade
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View article: Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort
Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort Open
OBJECTIVE To describe the prevalence and incidence of electrocardiogram (ECG) abnormalities and ECG-derived cardiovascular autonomic neuropathy (CAN) in the GRADE cohort of adults with type 2 diabetes (T2D) <10 years. RESEARCH DESIGN AN…
View article: Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort
Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort Open
Objective: To describe prevalence and incidence of electrocardiogram (ECG) abnormalities and ECG-derived cardiovascular autonomic neuropathy (CAN) in the GRADE cohort of adults with type 2 diabetes (T2D) Research Design and Methods: T2D in…
View article: Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort
Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort Open
Objective: To describe prevalence and incidence of electrocardiogram (ECG) abnormalities and ECG-derived cardiovascular autonomic neuropathy (CAN) in the GRADE cohort of adults with type 2 diabetes (T2D) Research Design and Methods: T2D in…
View article: An Unusual Case of Factitious Disorder Manifesting as Hypercalcemia Mediated by Exogenous Calcitriol
An Unusual Case of Factitious Disorder Manifesting as Hypercalcemia Mediated by Exogenous Calcitriol Open
Excessive 1, 25-dihydroxy vitamin D (calcitriol) is a pathophysiological cause of hypercalcemia. This form of hypercalcemia is seen in autoimmune conditions, fungal infections, lymphoma, and rare genetic diseases. A factious disorder manif…
View article: Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study)
Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study) Open
BACKGROUND: Cardiovascular disease is a major cause of morbidity and mortality in patients with type 2 diabetes. The effects of glucose-lowering medications on cardiovascular outcomes in individuals with type 2 diabetes and low cardiovascu…
View article: The Importance of Setting Treatment Goals for Cardiovascular Diseases
The Importance of Setting Treatment Goals for Cardiovascular Diseases Open
Background: Guidelines are issued by most major organizations that focus on a specific disease entity. Guidelines should be a significant help to the practicing physician who may not be up-to-date with the recent medical literature. Unfort…
View article: COVID-19 and Cardiovascular Disease—Two Pandemics, One Success
COVID-19 and Cardiovascular Disease—Two Pandemics, One Success Open
Background: COVID-19 has had a major impact on all facets of life in the United States. Its devastating effects have resulted in the mobilization of major resources, both at the national, state, and individual levels. This mobilization has…
View article: Prevention of Coronary Heart Disease: A Translational Clinical Challenge
Prevention of Coronary Heart Disease: A Translational Clinical Challenge Open
Introduction: Atherosclerotic cardiovascular disease is a dysmetabolic medical condition resulting in the #1 cause of morbidity and mortality in the United States. Coronary Artery Calcium (CAC) CT non-invasively identifies atherosclerosis …
View article: Guidelines for the Prevention of Symptomatic Cardiovascular Disease, Based upon the Presence of Coronary Artery Calcified Plaque—Provided by the Society for the Prevention of Symptomatic Heart Disease
Guidelines for the Prevention of Symptomatic Cardiovascular Disease, Based upon the Presence of Coronary Artery Calcified Plaque—Provided by the Society for the Prevention of Symptomatic Heart Disease Open
Introduction: The epidemic of atherosclerotic cardiovascular disease in the Western World accounts for the majority of morbidity and mortality in adults. This disease is on the increase, and previous recommendations using “risk equations” …
View article: Finance Policy for Public Health Disease Prevention: Addressing the Number One Cause of Death in the Western World
Finance Policy for Public Health Disease Prevention: Addressing the Number One Cause of Death in the Western World Open
Background: The lack of a finance policy to cover heart coronary artery disease CT imaging led to an epidemic of heart disease, the most common cause of death in the United States. The difficulty for many adults to pay $150 for CT heart im…
View article: Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study
Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study Open
OBJECTIVE The Diabetes Control and Complications Trial (DCCT) and its observational follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) demonstrated the dominant role of glycemia, second only to age, as a risk factor …
View article: Can the 2019 AHA/ACC Cardiovascular Guidelines Be Improved?
Can the 2019 AHA/ACC Cardiovascular Guidelines Be Improved? Open
The 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease for treatment of atherosclerosis in asymptomatic individuals is an advance over previously published recommendations. However, since all guidelines are based on…
View article: A Simplified Approach to Reducing Cardiovascular Risk
A Simplified Approach to Reducing Cardiovascular Risk Open
Context Cardiovascular disease remains the number one cause of morbidity and mortality in the United States, despite major advances in our understanding of its pathogenesis and prevention. One reason for this continued epidemic is the poor…
View article: A Pediatric Opportunity in Adolescents to Prevent Adult Heart Attacks
A Pediatric Opportunity in Adolescents to Prevent Adult Heart Attacks Open
Importance: Cardiovascular disease is the number one cause of death in the adult population, greater than all cancers combined. When a heart attack or stroke occurs, many individuals have no advance warning, thus making prevention difficul…
View article: 50 Ways To Save Your Heart
50 Ways To Save Your Heart Open
If you want to place a winning bet, bet that heart disease will kill you. Yes, you. Why? Because heart disease kills more people in the U.S. than any other disease, including cancer. We want to reverse that bet and save your life. How? You…
View article: The Basis of Atherosclerotic Guidelines—Time for a Change?
The Basis of Atherosclerotic Guidelines—Time for a Change? Open
Major advances have occurred within the last decade in the understanding of the pathogenesis of coronary artery disease. Not only are the underlying mechanisms now clearly defined, but effective medical therapies are available at low cost …
View article: Residual Cardiovascular Risk—Is Inflammation the Primary Cause?
Residual Cardiovascular Risk—Is Inflammation the Primary Cause? Open
Every cardiovascular clinical trial that has examined the beneficial effects of lowering LDL cholesterol to prevent cardiovascular events has demonstrated residual cardiovascular risk in the interventional treatment group. Residual risk is…