Explanipedia

T2 mapping of the articular cartilage as a biomarker for knee osteoarthritis: An analysis of the population-based Rotterdam Study Open

Netanja I. Harlianto, Jukka Hirvasniemi, Dirk H. J. Poot, Stefan Klein, Sita Bierma‐Zeinstra , et al. · 2025

In this population-based cohort, T₂ values were associated with BMI. Additionally, T₂ values in the lateral cartilage subregions were associated with MRI-based OA.

ABS1238-PARE CROSS-EUROPEAN INSIGHTS INTO PATIENT UNDERSTANDING OF OSTEOARTHRITIS: A MULTI-NATIONAL SURVEY Open

M-Ch. Verleyen, Caroline Lodge, A Keogh, Michael Petrides, D. Schiphof · 2025

Elucidating the initial symptoms and experiences of knee osteoarthritis: An international patient survey Open

Lauren King, Armaghan Mahmoudian, Jean W. Liew, Qiuke Wang, Ian Stanaitis , et al. · 2025

Individuals with knee OA recalled varied knee symptoms within the first year and few sought healthcare. We were unable to ascertain, from the perspective of patients, specific clinical features that indicated they had OA and not another co…

A Catalog of “Knee Friendly” Aerobic Exercises Developed for Patients With Knee Osteoarthritis: An International Patient Survey Open

Mathilde Espe Pedersen, Tanja Schjødt Jørgensen, Thomas Bandholm, Mathias Ried‐Larsen, Cecilie Bartholdy , et al. · 2025

Objective Aerobic exercise is recommended for the management of knee osteoarthritis (OA), but knee pain is often a barrier for participation. Some types of aerobic exercise may be less painful to undertake than others, though little is kno…

Patients' Perspectives on Participation in an Effectiveness Study on Footwear Modification for the First Metatarsophalangeal Joint Osteoarthritis: A Qualitative Study Open

Carla Braam, Sabine Kloprogge, D. Schiphof, Joyce B. J. van Meurs, Sita Bierma‐Zeinstra , et al. · 2025

Background The effectiveness of footwear modifications for the first metatarsophalangeal (MTP) joint osteoarthritis (OA) compared to usual general practitioner (GP) care has never been studied. Understanding patients' perspectives is essen…

Do self-management supportive interventions reduce healthcare utilization for people with musculoskeletal pain conditions? – A systematic review Open

Søren Grøn, Melker S. Johansson, D. Schiphof, Bart W. Koes, Alice Kongsted · 2024

Due to substantial heterogeneity in the types and measurement of healthcare utilization outcomes, it was not feasible to conduct a meta-analysis to estimate an overall effect size. A standardized way of reporting and measuring these outcom…

Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment Open

Annelotte H C Versloot, Jorien Veldwijk, Ramon P G Ottenheijm, Marloes Thoomes-de Graaf, Daniëlle van der Windt , et al. · 2024

Background Shoulder pain is common amongst adults, but little is known about patients’ preferences. Objective The aim of this study was to determine patients’ preferences for treatment options offered for shoulder pain in primary care. Met…

General Practitioners practice nurses and parents’ perspectives on childhood overweight management – a qualitative study Open

Maxime Adriana Maria van der Velden, Hevy Hassan, D. Schiphof, Madelon den Boeft, Sylvia Buis , et al. · 2024

BACKGROUND: Overweight and obesity in children is a major health problem. General practice might be a promising setting for identifying and for the first steps in the management of overweight and obesity in children. OBJECTIVE: To explore …

People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank Open

Marienke van Middelkoop, D. Schiphof, Miriam Hattle, Jacques Simkins, Kim L. Bennell , et al. · 2024

Planned or recent first consultation with the general practitioner for knee complaints: Is it indicative of early-stage knee osteoarthritis? Open

Nuria E J Jansen, D. Schiphof, Jos Runhaar, Edwin H. G. Oei, Sita Bierma‐Zeinstra , et al. · 2024

Within 24 months of initial consultation, over two-thirds of participants displayed MRI-defined structural KOA, and nearly half reported unacceptable symptom states. This study found no association between the duration of knee complaints a…

Weight-Bearing Physical Activity, Lower-Limb Muscle Mass, and Risk of Knee Osteoarthritis Open

YAHONG WU, Cindy G. Boer, Amy Hofman, D. Schiphof, Marienke van Middelkoop , et al. · 2024

Importance It has been demonstrated that total physical activity is not associated with risk of osteoarthritis. However, the association of different types of physical activity with incident knee osteoarthritis remains unclear. Objective T…

Changing the narrative on osteoarthritis: A call for global action Open

Clare Jinks, Angie Botto‐van Bemden, Samantha Bunzli, Jocelyn L. Bowden, Thorlene Egerton , et al. · 2024

Patterns of knee osteoarthritis management in general practice: a retrospective cohort study using electronic health records Open

Ilgin G. Arslan, Annemaria C. van Berkel, Jurgen Damen, Patrick Bindels, Marcel de Wilde , et al. · 2024

Exercise therapy for knee osteoarthritis pain: how does it work? A study protocol for a randomised controlled trial Open

David Beckwée, Jo Nijs, Sita Bierma‐Zeinstra, Lynn Leemans, Laurence Leysen , et al. · 2024

Introduction Muscle strengthening training (MST) and behavioural graded activity (BGA) show comparable effects on knee osteoarthritic (KOA) pain, but the mechanisms of action remain unclear. Both exercise-induced anti-inflammation and cent…

S6-3 Barriers, facilitators and strategies to implement physical activity advice and referral to exercise therapy for people with hip and knee OA in primary care Open

D. Schiphof, Jurgen Damen, Sita Bierma‐Zeinstra, Marienke van Middelkoop · 2023

Aim Osteoarthritis (OA) is one of the most common diseases in the Netherlands. Most people with OA are seen in primary care. Core treatment for knee and hip OA in general practice is information and advice on physical activity and referral…

Series: Public engagement with research. Part 4: Maximising the benefits of involving the public in research implementation Open

Laura Swaithes, L. Campbell, Sibyl Anthierens, Magdalena Skrybant, D. Schiphof , et al. · 2023

This final article in the four-part series focuses on the often neglected yet important role of the public in implementing research in General Practice and Primary Care more broadly. Experience in implementation of findings from research w…

Factors associated with meniscus volume in knees free of degenerative features Open

D. Xu, D. Schiphof, Jukka Hirvasniemi, Stefan Klein, Edwin H. G. Oei , et al. · 2023

Modifiable factors (varus alignment, BMI, physical activity level, and quadriceps muscle strength) and non-modifiable factors (higher age, injury, meniscus pathologies, meniscus extrusion, and cartilage lesions) were all associated with me…

Content Validition and Psychometric Evaluation of the Self-efficacy and Performance in Self-management Support Instrument for Physiotherapists Open

Anita Feleus, Lotte Wevers, D. Schiphof, John Verhoef, Susanne van Hooft , et al. · 2023

The SEPSS-PT questionnaire is a 40-item, Likert-scaled instrument with good content and construct validity, good internal consistency and reliability, and sufficient test-retest reliability. Future research in a larger and more diverse sam…

Implementing lifestyle‐related treatment modalities in osteoarthritis care: Identification of implementation strategies using the Consolidated Framework for Implementation Research‐Expert Recommendations for Implementing Change matching tool Open

Sjoukje E. Bouma, Inge van den Akker‐Scheek, D. Schiphof, L.H.V. van der Woude, Ron L. Diercks , et al. · 2023

Aims Despite recommendations in international clinical guidelines, lifestyle‐related treatment modalities (LRTMs) are currently underutilised in the conservative treatment of patients with hip and/or knee osteoarthritis. This study aimed t…

Nocturnal pain and fatigue in middle-aged persons with hip symptoms suspected to be osteoarthritis, is there a link in 10-year follow-up of the CHECK study? Open

Annemaria C. van Berkel, D. Schiphof, J.H. Waarsing, J. Runhaar, John M. van Ochten , et al. · 2023

In this cohort of participants suspected to have early hip OA, the prevalence of fatigue remained stable and the prevalence of nocturnal pain decreased slightly over 10-year follow-up. We did not find a mediating effect of nocturnal pain i…

Changes to consultations and diagnosis of osteoarthritis in primary care during the COVID-19 pandemic Open

Premysl Velek, Evelien de Schepper, D. Schiphof, W.E. van Spil, Martin Englund , et al. · 2023

We observed 47% reduction in GP consultations for musculoskeletal disorders during the first wave and 9% during the second wave. For hip and knee OA/complaints, the reductions were over 50% during the first, and 10% during the second wave.…

Metabolic Syndrome And The Progression Of Knee Osteoarthritis On MRI Open

Nuria E. Jansen, E. Molendijk, D. Schiphof, J. van Meurs, E. Oei , et al. · 2023

Metabolic syndrome and the progression of knee osteoarthritis on MRI Open

Nuria E J Jansen, Eveline Molendijk, D. Schiphof, Joyce B. J. van Meurs, Edwin H. G. Oei , et al. · 2023

Association between baseline meniscal extrusion and long-term incident knee osteoarthritis in two different cohorts Open

J.A. van der Voet, D. Schiphof, Dammis Vroegindeweij, Edwin H. G. Oei, Sita Bierma‐Zeinstra , et al. · 2023

Meniscal extrusion is significantly associated with long-term incident KOA. A high number of incident cases were attributable to extrusion.

3D patellar shape is associated with radiological and clinical signs of patellofemoral osteoarthritis Open

J.F.A. Eijkenboom, Nazlı Tümer, D. Schiphof, Edwin H. G. Oei, Amir A. Zadpoor , et al. · 2023

Patellar shape is associated with the prevalence of MRI-based PFOA in women. Some shape variants were also associated with clinical symptoms. Interestingly, one particular shape variant associated with the presence of MRI-based PFOA was ea…

A systematic review of the sex differences in risk factors for knee osteoarthritis Open

I Szilágyi, J.H. Waarsing, Joyce B. J. van Meurs, Sita Bierma‐Zeinstra, D. Schiphof · 2022

Objectives Previous systematic reviews focused on the evidence of common risk factors for knee OA (KOA); however, the effect and strength of association between risk factors and KOA might be different between the two sexes. The aim of the …

Accelerated menopausal changes as human disease model ‘FOCUM’ for the development of osteoarthritis and other degenerative disorders: protocol for a prospective cohort study Open

Eveline Molendijk, D. Schiphof, E.H. Oei, Robert‐Jan de Vos, P.K. Bos , et al. · 2022

Introduction The incidence of degenerative disorders, including osteoarthritis (OA), increases rapidly in women after menopause. However, the influence of the menopause is still insufficiently investigated due to the slowness of menopausal…

Associations between biomarkers of matrix metabolism and inflammation with pain and fatigue in participants suspected of early hip and or knee osteoarthritis: data from the CHECK study Open

Annemaria C. van Berkel, W.E. van Spil, D. Schiphof, J. Runhaar, John M. van Ochten , et al. · 2022

Skin autofluorescence, a non-invasive biomarker of advanced glycation end products, and its relation to radiographic and MRI based osteoarthritis Open

Komal Waqas, I Szilágyi, D. Schiphof, Cindy G. Boer, Sita Bierma‐Zeinstra , et al. · 2022

Higher SAF in women was associated with higher prosthesis prevalence and a trend towards higher cartilage loss on MRI. Our data presents inconclusive results between SAF and ROA in both sexes.

Plasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression Open

I Szilágyi, Costanza L. Vallerga, Cindy G. Boer, D. Schiphof, M. Arfan Ikram , et al. · 2022

Objectives The aim of this study was to identify biomarkers for radiographic OA severity and progression acting within the inflammation and metabolic pathways. Methods For 3517 Rotterdam Study participants, 184 plasma protein levels were m…

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