D. Scott Lim
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View article: Case Report: Acute methicillin-sensitive Staphylococcus aureus pericarditis in a diabetic patient
Case Report: Acute methicillin-sensitive Staphylococcus aureus pericarditis in a diabetic patient Open
Introduction Bacterial pericarditis is rare in the antibiotic era but remains potentially fatal due to rapid progression and high mortality. Herein, we report an unusual case of methicillin-sensitive Staphylococcus aureus (MSSA) pericardit…
View article: Forward Flow in Patients With Heart Failure and Functional Mitral Regurgitation: The COAPT Trial
Forward Flow in Patients With Heart Failure and Functional Mitral Regurgitation: The COAPT Trial Open
In the COAPT trial, lower baseline forward flow was associated with worse outcomes in medically managed patients, and those with low baseline forward flow derived the greatest absolute benefit from TEER. However, measured forward flow did …
View article: From diabetes care to prevention: review of prediabetes apps in the DACH region
From diabetes care to prevention: review of prediabetes apps in the DACH region Open
The rapid proliferation of mobile health (mHealth) apps for diabetes and prediabetes care has surged, driven by the growing interest and research in digital health interventions. However, as the number of these apps continues to expand, bo…
View article: Use of an ŌNŌ Retrieval Device for Removal of a Covered CP Stent
Use of an ŌNŌ Retrieval Device for Removal of a Covered CP Stent Open
We report the use of the ŌNŌ retrieval system to remove a fully inflated 3.9 cm length by 24 mm diameter NuDEL CP Stent from the left pulmonary artery. There was no damage to any cardiac structures or venous anatomy following stent removal…
View article: Transcatheter Edge-to-Edge Repair in Patients With Complex Tricuspid Valve Anatomy
Transcatheter Edge-to-Edge Repair in Patients With Complex Tricuspid Valve Anatomy Open
In patients with complex tricuspid anatomies, TEER with the TriClip system demonstrated excellent procedural safety with significant TR reduction and associated improvements in quality of life at 1 year.
View article: Analysis of Changes and Characteristics of Working Life Using the Working Life Table
Analysis of Changes and Characteristics of Working Life Using the Working Life Table Open
Objectives: The purpose of this study is to create a labor force life table and analyze the expected life expectancy by age, labor force participation rate, and reasons for leaving the workforce to identify the working period by age. Metho…
View article: Safety and efficacy of the DragonFly system for transcatheter valve repair of degenerative mitral regurgitation: one-year results of the DRAGONFLY-DMR trial
Safety and efficacy of the DragonFly system for transcatheter valve repair of degenerative mitral regurgitation: one-year results of the DRAGONFLY-DMR trial Open
The DRAGONFLY-DMR trial contributes to increasing evidence supporting the safety and efficacy of TEER therapy, specifically the DragonFly system, for treating patients with chronic symptomatic DMR 3+ to 4+ at prohibitive surgical risk.
View article: Echocardiography-guided percutaneous intramyocardial alginate hydrogel implants for heart failure: canine models with 6-month outcomes
Echocardiography-guided percutaneous intramyocardial alginate hydrogel implants for heart failure: canine models with 6-month outcomes Open
Background Echocardiography-guided percutaneous intramyocardial alginate-hydrogel implantation (PIMAHI) is a novel treatment approach for heart failure (HF). We validated PIMAHI safety and efficacy in canine HF models. Methods Fourteen can…
View article: Regurgitant volume to LA volume ratio in patients with secondary MR: the COAPT trial
Regurgitant volume to LA volume ratio in patients with secondary MR: the COAPT trial Open
Aims The conceptual framework of proportionate vs. disproportionate mitral regurgitation (MR) translates poorly to individual patients with heart failure (HF) and secondary MR. A novel index, the ratio of MR severity to left atrial volume …
View article: Percutaneous Mitral Valve Repair in Pediatric Patients
Percutaneous Mitral Valve Repair in Pediatric Patients Open
Rigorous clinical trials have demonstrated the safety and efficacy of Transcatheter Edge-to-Edge Repair (TEER) to treat severe secondary mitral regurgitation in adults with primary cardiomyopathy who have failed guideline directed medical …
View article: Cross-Validation of Risk Scores for Patients Undergoing Transcatheter Edge-to-Edge Repair for Mitral Regurgitation
Cross-Validation of Risk Scores for Patients Undergoing Transcatheter Edge-to-Edge Repair for Mitral Regurgitation Open
The COAPT risk score and MitraScore are simple tools that are useful for the prediction of 2-year mortality in patients eligible for or undergoing treatment with TEER.
View article: Mitral valve‐in‐valve with 4D intracardiac echocardiography: Procedural and imaging technique
Mitral valve‐in‐valve with 4D intracardiac echocardiography: Procedural and imaging technique Open
Transcatheter mitral valve‐in‐valve (ViV) has emerged as a safe and effective therapeutic option for patients with a degenerated mitral bioprosthesis. As procedural techniques mature and operator experience improve, there is a push to adop…
View article: Preemptive alcohol septal ablation prior to transcatheter mitral valve replacement
Preemptive alcohol septal ablation prior to transcatheter mitral valve replacement Open
Background Alcohol septal ablation (ASA) has been shown to increase the neo‐left ventricular outflow tract (LVOT) area before transcatheter mitral valve replacement (TMVR) but there is little literature on its success and use with dedicate…
View article: Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial
Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial Open
Background Left ventricular (LV) global longitudinal strain (GLS) provides incremental prognostic information over LV ejection fraction in patients with heart failure (HF) and secondary mitral regurgitation. We examined the prognostic impa…
View article: Two-Year Outcomes for Tricuspid Repair With a Transcatheter Edge-to-Edge Valve Repair From the Transatlantic TRILUMINATE Trial
Two-Year Outcomes for Tricuspid Repair With a Transcatheter Edge-to-Edge Valve Repair From the Transatlantic TRILUMINATE Trial Open
BACKGROUND: Tricuspid regurgitation (TR) is a common and progressive valve disease with significant mortality and hospitalization burden. Tricuspid transcatheter edge-to-edge repair provides a treatment option for high-risk patients with p…
View article: Incidence, Predictors, and Outcomes Associated With Worsening Renal Function in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial
Incidence, Predictors, and Outcomes Associated With Worsening Renal Function in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial Open
Background The incidence and implications of worsening renal function (WRF) after mitral valve transcatheter edge‐to‐edge repair (TEER) in patients with heart failure (HF) are unknown. Therefore, the aim of this study was to determine the …
View article: Transcatheter Mitral Valve Replacement Versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score–Matched Comparison
Transcatheter Mitral Valve Replacement Versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score–Matched Comparison Open
Background: Transcatheter mitral valve replacement (TMVR) is an emerging therapeutic alternative for patients with secondary mitral regurgitation (MR). Outcomes of TMVR versus guideline-directed medical therapy (GDMT) have not been investi…
View article: Mortality Associated with Proportionality of Secondary Mitral Regurgitation After Transcatheter Mitral Valve Repair: MFIRE Registry
Mortality Associated with Proportionality of Secondary Mitral Regurgitation After Transcatheter Mitral Valve Repair: MFIRE Registry Open
BACKGROUND The association, if any, between the effective regurgitant orifice (EROA) to left ventricular end-diastolic volume (LVEDV) ratio and 1-year mortality is controversial in patients undergoing mitral transcatheter edge-to-edge repa…
View article: Impact of Peripheral Artery Disease in Patients With Heart Failure Undergoing Transcatheter Mitral Valve Repair: The COAPT Trial
Impact of Peripheral Artery Disease in Patients With Heart Failure Undergoing Transcatheter Mitral Valve Repair: The COAPT Trial Open
Background Peripheral artery disease (PAD) and heart failure (HF) often coexist. Whether PAD influences outcomes of transcatheter mitral valve repair (TMVr) in patients with HF and severe secondary mitral regurgitation is unknown. The obje…
View article: Maximally tolerated guideline-directed medical therapy and barriers to optimization in patients with heart failure with reduced ejection fraction: the COAPT trial
Maximally tolerated guideline-directed medical therapy and barriers to optimization in patients with heart failure with reduced ejection fraction: the COAPT trial Open
Background The COAPT trial of MitraClip therapy employed a central screening eligibility committee (CSEC) of heart failure (HF) experts to ensure the use of maximally tolerated guideline-directed medical therapy (GDMT) and systematically d…
View article: First-in-Human Study of the Novel Transcatheter Mitral Valve Repair System for Mitral Regurgitation
First-in-Human Study of the Novel Transcatheter Mitral Valve Repair System for Mitral Regurgitation Open
Transcatheter mitral valve intervention treatment is a promising alternative therapy for patients with severe mitral regurgitation (MR). This is a multicenter, prospective, first-in-human study of transcatheter edge-to-edge repair (TEER) u…