Explanipedia

Predictors of 5-Year Persistence of Antibody Responses to Zoster Vaccines Open

Adriana Weinberg, D. Scott Schmid, Jessica Leung, Michael Johnson, Congrong Miao , et al. · 2023

Background Protection against herpes zoster is primarily conferred by cell-mediated immunity. However, anti–varicella-zoster virus (VZV) glycoprotein (anti-gp) antibody responses to zoster vaccine live (ZVL) are correlated with protection,…

Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster Open

Kerry J. Laing, Werner J. D. Ouwendijk, Victoria Campbell, Christopher L. McClurkan, Shahin Mortazavi , et al. · 2022

Development of antibody-dependent cellular cytotoxicity in response to recombinant and live-attenuated herpes zoster vaccines Open

Seong Yeon Park, Myron J. Levin, Jennifer Canniff, Michael Johnson, D. Scott Schmid , et al. · 2022

Fraternal Twins: The Enigmatic Role of the Immune System in Alphaherpesvirus Pathogenesis and Latency and Its Impacts on Vaccine Efficacy Open

Barry T. Rouse, D. Scott Schmid · 2022

Although the establishment, maintenance and reactivation from alphaherpesvirus latency is far from fully understood, some things are now manifestly clear: Alphaherpesvirus latency occurs in neurons of the peripheral nervous system and cont…

Cross-Sectional Retrospective Study to Identify Clinical and Radiographic Features Associated With VZV Reactivation in Cryptogenic Stroke Patients With CSF Testing Open

Ekaterina Bakradze, Charles Esenwa, D. Scott Schmid, Kathryn F. Kirchoff-Torres, Daniel Antoniello , et al. · 2022

Background and Purpose: A large proportion of ischemic stroke patients lack a definitive stroke etiology despite extensive diagnostic testing. Varicella-Zoster Virus (VZV) can directly invade blood vessels causing vasculitis and may be ass…

ICTV Virus Taxonomy Profile: Herpesviridae 2021 Open

Derek Gatherer, Daniel P. Depledge, Carol A. Hartley, Moriah L. Szpara, Paola K. Vaz , et al. · 2021

Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components. The linear, double-stranded DNA genomes of 125–241 kbp contain 70–170 ge…

Humoral and cellular immune responses to recombinant herpes zoster vaccine in patients with chronic lymphocytic leukemia and monoclonal B cell lymphocytosis Open

Eli Muchtar, Amber B. Koehler, Michael Johnson, Kari G. Rabe, Wei Ding , et al. · 2021

Monoclonal B‐cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL) are clonal B‐cell disorders associated with an increased risk of infections and impaired vaccination responses. We investigated the immunogenicity of recombinant …

Comparative Antibody Responses to the Live-Attenuated and Recombinant Herpes Zoster Vaccines Open

D. Scott Schmid, Congrong Miao, Jessica Leung, Michael Johnson, Adriana Weinberg , et al. · 2021

These observations further distinguish the immunogenicity and duration of the immune response of the two vaccines. In addition, measurements of functional humoral immunity (IgG avidity and neutralizing antibody) in response to zoster immun…

Clinical and Epidemiological Findings from Enhanced Monkeypox Surveillance in Tshuapa Province, Democratic Republic of the Congo During 2011–2015 Open

Erin Whitehouse, Jesse Bonwitt, Christine M. Hughes, Robert Shongo Lushima, Toutou Likafi , et al. · 2021

Background Monkeypox is a poorly described emerging zoonosis endemic to Central and Western Africa. Methods Using surveillance data from Tshuapa Province, Democratic Republic of the Congo during 2011–2015, we evaluated differences in incid…

Safety and immunogenicity of adjuvanted recombinant subunit herpes zoster vaccine in lung transplant recipients Open

Cédric Hirzel, Arnaud G. L’Huillier, Victor H. Ferreira, Tina Marinelli, Terrance Ku , et al. · 2021

Communicability of varicella before rash onset: a literature review Open

Mona Marin, Jessica Leung, Adriana Lopez, Leah Shepersky, D. Scott Schmid , et al. · 2021

Varicella poses an occupational risk and a nosocomial risk for susceptible healthcare personnel and patients, respectively. Patients with varicella are thought to be infectious from 1 to 2 days before rash onset until all lesions are crust…

A Tale of Two Viruses: Coinfections of Monkeypox and Varicella Zoster Virus in the Democratic Republic of Congo Open

Christine M. Hughes, Lindy Liu, Whitni Davidson, Kay Radford, Kimberly Wilkins , et al. · 2020

Recent enhanced monkeypox (MPX) surveillance in the Democratic Republic of Congo, where MPX is endemic, has uncovered multiple cases of MPX and varicella zoster virus (VZV) coinfections. The purpose of this study was to verify if coinfecti…

Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells Open

Andrew N. Bubak, Cheryl L. Beseler, Christina N. Como, Christina Coughlan, Noah R. Johnson , et al. · 2020

Background Varicella zoster virus (VZV) vasculopathy is characterized by persistent arterial inflammation leading to stroke. Studies show that VZV induces amyloid formation that may aggravate vasculitis. Thus, we determined if VZV central …

Persistence of Varicella-Zoster Virus-Specific Plasma Cells in Adult Human Bone Marrow following Childhood Vaccination Open

Christiane S. Eberhardt, Andreas Wieland, Tahseen H. Nasti, Alba Grifoni, Elizabeth Wilson , et al. · 2020

Childhood varicella-zoster virus (VZV) immunization induces immune memory responses that protect against primary VZV infection, chicken pox. In the United States, routine childhood VZV vaccination was introduced only 2 decades ago. Hence, …

Analysis of the reiteration regions (R1 to R5) of varicella-zoster virus Open

Nancy J. Jensen, Daniel P. Depledge, Terry Fei Fan Ng, Jessica Leung, Mark Quinlivan , et al. · 2020

<i>Notes from the Field:</i> Monkey Bite in a Public Park and Possible Exposure to Herpes B Virus — Thailand, 2018 Open

Alexander C. Wu, Steven I. Rekant, Elizabeth R. Baca, Renee M. Jenkins, Ludmila Perelygina , et al. · 2020

Vaccine Oka Varicella Meningitis in Two Adolescents Open

Whitney E. Harrington, Sayonara Mató, Lauri Burroughs, Paul A. Carpenter, Anne A. Gershon , et al. · 2019

The live-attenuated varicella vaccine, a routine immunization in the United States since 1995, is both safe and effective. Like wild-type varicella-zoster virus, however, vaccine Oka (vOka) varicella can establish latency and reactivate as…

Clinical Diagnostic Testing for Human Cytomegalovirus Infections Open

Raymund R. Razonable, Naoki Inoue, Swetha Pinninti, Suresh B. Boppana, Tiziana Lazzarotto , et al. · 2019

Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death. HCMV infections are also responsible for more co…

Recurrent herpes zoster in the Shingles Prevention Study: Are second episodes caused by the same varicella-zoster virus strain? Open

Ruth Harbecke, Nancy J. Jensen, Daniel P. Depledge, Gary R. Johnson, Mark E. Ashbaugh , et al. · 2019

Herpes zoster (HZ) is caused by reactivation of varicella zoster virus (VZV) that established latency in sensory and autonomic neurons during primary infection. In the Shingles Prevention Study (SPS), a large efficacy trial of live attenua…

Patient report of herpes zoster pain: Incremental benefits of zoster vaccine live Open

Katia Bruxvoort, Anna S. Liang, Rafael Harpaz, Lei Qian, Lina S. Sy , et al. · 2019

Varicella in Tshuapa Province, Democratic Republic of Congo, 2009–2014 Open

Jessica Leung, Andrea M. McCollum, Kay Radford, Christine M. Hughes, Adriana Lopez , et al. · 2019

Objective To describe varicella cases in Tshuapa Province of the Democratic Republic of the Congo identified during monkeypox surveillance. Methods Demographic, clinical and epidemiological data were collected from each suspected monkeypox…

Mixing It Up: New Insights Into Interspecies Recombination Between Herpes Simplex Virus Type 1 and 2 Open

D. Scott Schmid · 2019

Herpes simplex viruses (HSV-1 and HSV-2) are closely related alphaherpesviruses, with more than 80% identity at the deoxyribonucleic acid (DNA) sequence level [1]. More than two thirds of the world’s population is estimated to have been in…

European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? Open

Jens Nielsen, Lasse S. Vestergaard, Lukas Richter, D. Scott Schmid, Natalia Bustos Sierra , et al. · 2019

Objectives Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause exce…

Genotypes of clinical varicella-zoster virus isolates from Manaus, Brazil Open

Michele de Souza Bastos, Jennifer Folster, Otávio Primo de Alvarenga, Daniele de Araujo Sampaio, Ronaldo Marques Pontes Rabelo , et al. · 2019

This study provides insights into the circulating VZV genotypes in Manaus prior to widespread vaccination.

CMV on surfaces in homes with young children: results of PCR and viral culture testing Open

Minal M. Amin, Jennifer Stowell, William S Hendley, Philip Garcia, D. Scott Schmid , et al. · 2018

Family history of zoster and risk of developing herpes zoster Open

Hung Fu Tseng, Margaret Chi, Peggy Hung, Rafael Harpaz, D. Scott Schmid , et al. · 2017

Donor-derived Kaposi’s sarcoma in a liver–kidney transplant recipient Open

Sheila C. Dollard, David D. Douglas, S. V. Basavaraju, D. Scott Schmid, Matthew J. Kuehnert , et al. · 2017

Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons Open

Nancy J. Jensen, Pierre Rivailler, Hung Fu Tseng, Mark L. Quinlivan, Kay Radford , et al. · 2017

We report whole-genome sequences (WGSs) for four varicella-zoster virus (VZV) samples from a shingles study conducted by Kaiser Permanente of Southern California. Comparative genomics and phylogenetic analysis of all published VZV WGSs rev…

Evaluation of a TaqMan Array Card for Detection of Central Nervous System Infections Open

Clayton Onyango, Vladimir N. Loparev, Shirley Lidechi, Vinod Bhullar, D. Scott Schmid , et al. · 2017

Infections of the central nervous system (CNS) are often acute, with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that m…

Arm Paralysis After Routine Childhood Vaccinations: Application of Advanced Molecular Methods to the Causality Assessment of an Adverse Event After Immunization Open

Jana Shaw, Neal A. Halsey, Adriana Weinberg, D. Scott Schmid, Kirsten St. George , et al. · 2016

Post-licensure surveillance for adverse events following immunizations (AEFI) can identify rare complications of vaccinations and rigorous vaccine adverse event causality assessments can help to identify possible causal relationships. We r…

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