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View article: Anti-oxidative and anti-inflammatory effects of the phosphodiesterase 3/4 inhibitor ensifentrine
Anti-oxidative and anti-inflammatory effects of the phosphodiesterase 3/4 inhibitor ensifentrine Open
Ensifentr ine is a dual PDE3/4 inhibitor that improves lung function and symptoms in COPD patients. Ensifentrine has anti-inflammatory effects, but these have not been studied in cells from COPD patients. Oxidative stress is increased in t…
View article: An Uncommon Multimodal Management Approach for Low-grade Appendiceal Mucinous Neoplasm With Pseudomyxoma Peritonei and Mucinous Borderline Ovarian Tumor
An Uncommon Multimodal Management Approach for Low-grade Appendiceal Mucinous Neoplasm With Pseudomyxoma Peritonei and Mucinous Borderline Ovarian Tumor Open
Introduction and Importance: Low-grade appendiceal mucinous neoplasm (LAMN) is a rare epithelial tumor characterized by mucin production and potential dissemination into the peritoneal cavity, resulting in pseudomyxoma peritonei (PMP). The…
View article: Bupropion-induced tinnitus after dose escalation: a rare and reversible adverse effect – a case report
Bupropion-induced tinnitus after dose escalation: a rare and reversible adverse effect – a case report Open
Introduction and Importance: Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI) commonly prescribed for major depressive disorder and smoking cessation. It is preferred for its minimal serotonergic activity and favorable side…
View article: A rare case report of supernumerary nostril in an infant: clinical presentation, surgical management, and literature review
A rare case report of supernumerary nostril in an infant: clinical presentation, surgical management, and literature review Open
Introduction and Importance: Supernumerary nostril is an exceedingly rare congenital malformation characterized by the presence of an accessory nostril in addition to the normal nasal openings. The anomaly may or may not communicate with t…
View article: Sputum Cytokine Repeatability in COPD
Sputum Cytokine Repeatability in COPD Open
A multiplex immunoassay used at repeated visits in COPD patients showed a high degree of reproducibility for the majority of analytes. There were reproducible inflammatory signatures in sputum associated with clinical characteristics in CO…
View article: Sinonasal extraosseous ewing’s sarcoma of the nasal cavity with EWSR1: FLI1 fusion – a rare case report from Nepal
Sinonasal extraosseous ewing’s sarcoma of the nasal cavity with EWSR1: FLI1 fusion – a rare case report from Nepal Open
Introduction: Ewing’s sarcoma is a rare, aggressive malignancy primarily originating in bones. Sinonasal extraosseous Ewing sarcoma (EES) displays morphologic heterogeneity that often correlates with underlying genotypes, most commonly the…
View article: Inherited Type-1 renal tubular acidosis with short stature: a rare case report from Nepal
Inherited Type-1 renal tubular acidosis with short stature: a rare case report from Nepal Open
Introduction: Distal Renal Tubular Acidosis (dRTA), or Type 1 RTA, is a rare disorder characterized by the failure of alpha-intercalated cells in the distal nephron to excrete hydrogen ions. This leads to a normal anion gap metabolic acido…
View article: Efficacy of inhaled nebulised unfractionated heparin to prevent intubation or death in hospitalised patients with COVID-19: an investigator-initiated international meta-trial of randomised clinical studies
Efficacy of inhaled nebulised unfractionated heparin to prevent intubation or death in hospitalised patients with COVID-19: an investigator-initiated international meta-trial of randomised clinical studies Open
The Sponsor of the meta-trial was the INHALE-HEP Collaborative Research Group (CRG); investigators of each contributing study were members of the INHALE-HEP CRG. No funding was received for the meta-trial. The Brazilian study was funded by…
View article: Green Chemistry Approaches in Phytoremediation: A Review
Green Chemistry Approaches in Phytoremediation: A Review Open
Phytoremediation, the use of plants to remediate contaminated environments, has gained significant attention as an eco-friendly and sustainable approach to address soil and water pollution. This review focuses on the integration of green c…
View article: Microenvironment‐Driven Mast Cell Plasticity: Insights From Cytokine‐Activated Gene Signatures in Skin and Respiratory Diseases
Microenvironment‐Driven Mast Cell Plasticity: Insights From Cytokine‐Activated Gene Signatures in Skin and Respiratory Diseases Open
Mast cells (MCs) rapidly adapt to the microenvironment due to the plethora of cytokine receptors expressed. Understanding microenvironment‐primed immune responses is essential to elucidate the phenotypic/functional changes MCs undergo, and…
View article: AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma
AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma Open
Aims Inhaled corticosteroids (ICS) plus bronchodilator are recommended for the treatment of asthma. Targeting the JAK1‐dependent pathway may be an alternative for asthma management in patients with incomplete response to ICS. The aim of th…
View article: Detecting Small Airways Dysfunction in Asthma: Rationale, Findings, and Future of ATLANTIS
Detecting Small Airways Dysfunction in Asthma: Rationale, Findings, and Future of ATLANTIS Open
Small airway dysfunction (SAD) is both common and clinically relevant in patients with asthma. However, there is no recognized "gold standard" approach for the identification of SAD in clinical practice. The ATLANTIS (AssessmenT of smalL A…
View article: The Advantages of FEV1 Percent Predicted Change During Bronchial Challenge Testing
The Advantages of FEV1 Percent Predicted Change During Bronchial Challenge Testing Open
View article: In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients with COPD Using Functional Respiratory Imaging
In Silico Lung Deposition Profiles of Three Single-Inhaler Triple Therapies in Patients with COPD Using Functional Respiratory Imaging Open
These findings provide quantitative insights into relative lung deposition distribution profiles and efficiency of delivery for 3 inhaler options. Further research is needed to understand if these deposition patterns could translate into r…
View article: Chronic Obstructive Pulmonary Disease (COPD): Developments in Pharmacological Treatments
Chronic Obstructive Pulmonary Disease (COPD): Developments in Pharmacological Treatments Open
The immediate goals of pharmacological management in chronic obstructive pulmonary disease (COPD) are to minimise symptoms and improve exercise performance. The longer-term goals are to reduce the future risk of exacerbations, lung functio…
View article: The low global warming potential propellant HFA-152a does not induce bronchoconstriction or impair mucociliary clearance
The low global warming potential propellant HFA-152a does not induce bronchoconstriction or impair mucociliary clearance Open
These two studies suggest a switch in propellant from HFA-134a to HFA-152a is unlikely to induce post-dose bronchoconstriction in asthma or impact lung MCC, and is not accompanied by any safety concerns.
View article: Pharmacology: The Powerhouse of Drug Discovery and Therapy
Pharmacology: The Powerhouse of Drug Discovery and Therapy Open
View article: Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study
Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study Open
Aims Cardiovascular disease is a common comorbidity in chronic obstructive pulmonary disease. Yet, cardiovascular disease and risk are underdiagnosed in chronic obstructive pulmonary disease and are often undertreated, increasing the risk …
View article: What’s new in the 2025 GOLD report
What’s new in the 2025 GOLD report Open
View article: Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci
Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci Open
Asthma is a genetically complex inflammatory airway disease associated with more than 200 SNPs. However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples are unknown. Here, we aimed to conduct exp…
View article: Dupilumab Improves Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS
Dupilumab Improves Health-Related Quality of Life and Respiratory Symptoms in Patients With COPD and Type 2 Inflammation: BOREAS and NOTUS Open
gov.
View article: Predicting response to benralizumab in patients with COPD: a plain language summary of publication of the GALATHEA and TERRANOVA studies
Predicting response to benralizumab in patients with COPD: a plain language summary of publication of the GALATHEA and TERRANOVA studies Open
Summary What is this summary about? ● This is a plain language summary of two articles originally published in The New England Journal of Medicine and The Lancet Respiratory Medicine . These articles presented the results of GALATHEA and T…
View article: Small Airways Dysfunction Independently Predicts Exacerbation Risk in Patients with Well-Controlled Asthma: An Analysis within the ATLANTIS Study
Small Airways Dysfunction Independently Predicts Exacerbation Risk in Patients with Well-Controlled Asthma: An Analysis within the ATLANTIS Study Open
View article: Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial
Efficacy and safety of tezepelumab versus placebo in adults with moderate to very severe chronic obstructive pulmonary disease (COURSE): a randomised, placebo-controlled, phase 2a trial Open
AstraZeneca and Amgen.
View article: Results from a UK consensus about the optimal prescribing of medium strength triple therapy in uncontrolled adult asthma patients in the NHS
Results from a UK consensus about the optimal prescribing of medium strength triple therapy in uncontrolled adult asthma patients in the NHS Open
A BSTRACT Context: An inhaled corticosteroid (ICS) in combination with a long-acting β2-agonist (LABA) is a common treatment approach for asthma patients not controlled on ICS alone, but a significant proportion of patients remain uncontro…
View article: Reply to Ariel and Suissa and to Calzetta and Rogliani
Reply to Ariel and Suissa and to Calzetta and Rogliani Open
View article: Histopathology of the small airways: Similarities and differences between ageing and COPD
Histopathology of the small airways: Similarities and differences between ageing and COPD Open
Age-related lung function decline is associated with small airway closure and gas trapping. The mechanisms which cause these changes are not fully understood. It has been suggested that COPD is caused by accelerated ageing. We have investi…
View article: Dupilumab reduces exacerbations and improves lung function in patients with chronic obstructive pulmonary disease and emphysema: Phase 3 randomized trial (BOREAS)
Dupilumab reduces exacerbations and improves lung function in patients with chronic obstructive pulmonary disease and emphysema: Phase 3 randomized trial (BOREAS) Open
Dupilumab efficacy was similar in patients with COPD and type 2 inflammation, with or without investigator-reported emphysema.
View article: Expiratory flow limitation development index (ELDI): a novel method of assessing respiratory mechanics in COPD
Expiratory flow limitation development index (ELDI): a novel method of assessing respiratory mechanics in COPD Open
View article: Type 2 inflammation in COPD: is it just asthma?
Type 2 inflammation in COPD: is it just asthma? Open
COPD is a heterogeneous condition, with tobacco smoking being the main environmental risk factor. The presence of type 2 (T2) inflammation is a well-recognised feature of asthma; however, it is now apparent that a subset of COPD patients a…