Daniel Timofte
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Complications After Bariatric Surgery: Insights from a 14-Year Single-Institutional Study Without Fistula Open
Background/Objectives: Obesity imposes a significant and growing burden on healthcare systems worldwide. Bariatric surgery remains the most effective long-term treatment for morbid obesity, but its success depends heavily on the quality of…
View article: Gut Microbiota and Short-Chain Fatty Acids: Key Factors in Pediatric Obesity and Therapeutic Targets
Gut Microbiota and Short-Chain Fatty Acids: Key Factors in Pediatric Obesity and Therapeutic Targets Open
Obesity in the pediatric population has become a public health problem with an increasing prevalence in recent years. The gut microbiota and its metabolites, especially short-chain fatty acids (SCFAs), play vital roles in the development o…
Management of Gastric Fistulas After Gastric Sleeve Using E-VAC Therapy Open
Background and Clinical Significance: Sleeve gastrectomy is an effective and widely performed bariatric procedure that provides long-term, sustained weight loss, but it carries risks of early and late complications. Among these, gastric fi…
The hidden burden: incidentalomas detected on abdominopelvic computed tomography in bariatric surgery candidates - a single-center experience. Open
Bariatric surgery (BS) is currently one of the major breakthroughs in the management of patients with morbid obesity, showing outstanding long-term results. While an abdominopelvic computed tomography (CT) aims to analyze fat distribution …
Adaptation of Endoluminal Vacuum Therapy via Extra-Luminal Access in the Treatment of a High Pharyngeal Fistula: Technical Feasibility and Outcome Open
Background: Perforation of the piriform sinus is a rare but severe clinical event that can lead to cervico-thoracic mediastinitis, a life-threatening condition requiring urgent multidisciplinary intervention. Among its etiologies, accident…
The value of metabolic surgery for patients with obesity and type 2 diabetes in Romania Open
Background Metabolic surgery is a well-established intervention for managing severe obesity and type 2 diabetes, offering significant long-term health benefits. In Europe, procedures such as sleeve gastrectomy and Roux-en-Y gastric bypass …
The Impact of Bariatric Surgery on Gut Microbiota Composition and Diversity: A Longitudinal Analysis Using 16S rRNA Sequencing Open
Bariatric surgery is considered the most effective treatment for obesity and its associated metabolic disorders, yet the underlying mechanisms are only partially understood. Evidence suggests that the gut microbiota plays an important role…
BARIATRIC SURGERY AND PERIODONTAL HEALTH: PERSPECTIVES ON PERIODONTAL DISEASE INDEX AND DECAY MISSING FILLED INDEX Open
Aim: To analyze the impact of bariatric surgery on periodontal health by assessing the PDI (Periodontal Disease Index) and DMFT (Decay Missing Filled Index) in patients with obesity. The study seeks to correlate weight loss and changes in …
View article: From Traditional Medical Patterns to Artificial Intelligence: The Applicability of Digital Biomarkers in Reinventing Personalised Nutrition
From Traditional Medical Patterns to Artificial Intelligence: The Applicability of Digital Biomarkers in Reinventing Personalised Nutrition Open
The purpose of this study is to assess the association between digital biomarkers on diet compliance and other health-related outcomes in adults willing to change their eating behaviours. This study employed a mixed-method, cross-sectional…
The Therapeutic Use and Potential of MSCs: Advances in Regenerative Medicine Open
Mesenchymal stem cells (MSCs) have emerged as a relevant strategy in regenerative medicine due to their multipotent differentiation capacity, immunomodulatory properties, and therapeutic applications in various medical fields. This review …
View article: Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing
Dexketoprofen-Loaded Alginate-Grafted Poly(N-vinylcaprolactam)-Based Hydrogel for Wound Healing Open
All acute and chronic wound management strategies have limitations. Therefore, there is an urgent need to develop new treatment options for wound healing. Hydrogels based on natural polymers offer advantages in wound management because the…
The Use of the Masquelet Technique in the Treatment of Pathological Distal Third Femoral Fracture Secondary to Chronic Osteomyelitis Open
Introduction: Chronic osteomyelitis is a persistent infection of the bone that poses significant challenges, particularly when associated with pathological fractures and extensive bone defects. This case report highlights the application o…
The Role of Artificial Intelligence in Bariatric Surgery: Perspectives and Modern Applications Open
Artificial intelligence (AI) is having a major impact in the field of bariatric surgery (BS) as it helps improve outcomes for patients with severe obesity. This advanced technology optimises clinical decision-making processes and helps red…
View article: Dietary Habits, Obesity, and Bariatric Surgery: A Review of Impact and Interventions
Dietary Habits, Obesity, and Bariatric Surgery: A Review of Impact and Interventions Open
Eating behavior encompasses the psychological, physiological, and environmental factors influencing food intake. Dysregulation in eating behavior, such as emotional eating, binge eating, or loss of satiety signals, contributes to excessive…
View article: Cardiovascular Profile and Cardiovascular Imaging After Bariatric Surgery: A Narrative Review
Cardiovascular Profile and Cardiovascular Imaging After Bariatric Surgery: A Narrative Review Open
Background and Objectives: Up until now, behavioral interventions and pharmacological therapies were the main approach available for the management of obesity. Diet and exercise, when used as a singular therapeutic method, are inadequate f…
Obesity, Osteoarthritis, and Myokines: Balancing Weight Management Strategies, Myokine Regulation, and Muscle Health Open
Obesity and osteoarthritis (OA) are increasingly prevalent conditions that are intricately linked, with each exacerbating the other’s pathogenesis and worsening patient outcomes. This review explores the dual impact of obesity on OA, highl…
View article: Rifampicin-Loaded PLGA/Alginate-Grafted pNVCL-Based Nanoparticles for Wound Healing
Rifampicin-Loaded PLGA/Alginate-Grafted pNVCL-Based Nanoparticles for Wound Healing Open
The topical therapy with rifampicin (RF)-based formulations is beneficial for treating postoperative wound infections and to accelerate healing. Despite recent research highlighting the antibiotic’s significant anti-inflammatory properties…
View article: Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing
Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing Open
The topical therapy with rifampicin (RF)-based formulations is beneficial to treat infections and to healing the wounds. Despite recent research highlighting the antibiotic's significant an-ti-inflammatory properties, limited topical …
Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management Open
Osteoarthritis (OA) is a progressive chronic disease affecting the articular joints, leading to pain and disability. Unlike traditional views that primarily link OA to aging, recent understanding portrays it as a multifactorial degenerativ…
Accidental hypothermia in the largest emergency hospital in North-Eastern Romania Open
Introduction Accidental hypothermia (AH) presents a significant mortality risk, even in individuals with good health. Early recognition of the parameters associated with negative prognosis could save more lives. Methods This was a pilot, r…
Laparoscopy in Abdominal Emergencies. Romanian Association for Endoscopic Surgery Consensus. Part I (Trauma) Open
Background: laparoscopy has emerged as a pivotal tool for the management of acute abdominal pathologies. It provides diagnostic and therapeutic advantages, enabling surgeons to evaluate and address diverse acute abdominal conditions using …
Retroperitoneal liposarcoma: unveiling diagnostic delays and multimodal treatment dilemmas Open
Liposarcomas are a prevalent subtype of soft tissue sarcomas, constituting less than 1% of all malignancies. Originating in the adipose tissue, they can manifest in various locations and are categorized by the World Health Organization int…
The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases Open
Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involveme…
The Impact of Bariatric Surgery on Quality of Life in Patients with Obesity Open
Obesity has become a widespread health problem influencing people’s health, general well-being, and healthcare costs. It also represents an important risk factor for multiple comorbidities and malignancies. Objectives: the primary objectiv…
Atrial Fibrillation and Chronic Coronary Ischemia: A Challenging Vicious Circle Open
Atrial fibrillation, the most frequent arrhythmia in clinical practice and chronic coronary syndrome, is one of the forms of coronary ischemia to have a strong dual relationship. Atrial fibrillation may accelerate atherosclerosis and may i…
View article: Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity
Role of Chemerin and Perivascular Adipose Tissue Characteristics on Cardiovascular Risk Assessment by Arterial Stiffness Markers in Patients with Morbid Obesity Open
Background and objective: The development of arterial stiffness (AS) in obesity is a multifactorial and complex process. The pleomorphic actions of adipokines and their local activity in perivascular adipose tissue (PVAT) are potential mod…
Mesenchymal Stem Cell-Derived Exosomes Modulate Angiogenesis in Gastric Cancer Open
Individualized gastric cancer (GC) treatment aims at providing targeted therapies that translate the latest research into improved management strategies. Extracellular vesicle microRNAs have been proposed as biomarkers for GC prognosis. He…
Twelve-Month Outcomes in Patients with Obesity Following Bariatric Surgery—A Single Centre Experience Open
Background: As obesity rates continue to rise worldwide, many surgeons consider bariatric procedures as a possible cure for the upcoming obesity pandemic. Excess weight represents a risk factor for multiple metabolic disorders, especially …
View article: Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging
Determinants of Arterial Stiffness in Patients with Morbid Obesity. The Role of Echocardiography and Carotid Ultrasound Imaging Open
Background and objective: Morbid obesity is accompanied by an increased cardiovascular (CV) risk, which justifies a multidisciplinary, integrative approach. Arterial stiffness has a well-defined additional role in refining individual CV ri…
OBESITY AND DEPRESSION INTERTWINED – A NARRATIVE REVIEW Open
Both pathologies—obesity and depression—have high prevalence rates and have serious negative effects on the public's health. In recent meta-analyses, clinical trials, and epidemiological studies, they have been observed in people of all ra…