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View article: Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment
Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment Open
The stromal compartment of many solid tumors plays a critical role in shaping an immunosuppressive microenvironment that limits the effectiveness of immune-based therapies1. Among stromal constituents, cancer-associated fibroblasts (CAFs) …
View article: Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment
Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment Open
The stromal compartment of many solid tumors plays a critical role in shaping an immunosuppressive microenvironment that limits the effectiveness of immune-based therapies1. Among stromal constituents, cancer-associated fibroblasts (CAFs) …
View article: A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma
A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma Open
The tumor microenvironment (TME) of chronic inflammation-associated cancers (CIACs) is shaped by cycles of injury and maladaptive repair, yet the principles organizing fibrotic stroma in these tumors remain unclear. Here, we applied the co…
View article: A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction
A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction Open
Chronic lung injury generates metaplasia which occasionally, but ominously, progresses to squamous dysplasia and squamous lung cancer. To identify mechanisms through which disrupted tissue homeostasis contributes to malignant initiation an…
View article: Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment
Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment Open
The stromal compartment of many solid tumors plays a critical role in shaping an immunosuppressive microenvironment that limits the effectiveness of immune-based therapies 1 . Among stromal constituents, cancer-associated fibroblasts (CAFs…
View article: Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett’s esophagus through progression to cancer
Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett’s esophagus through progression to cancer Open
Barrett’s esophagus (BE), a metaplastic condition that is the only known precursor for esophageal adenocarcinoma (EAC), is relatively common, but progression to cancer is infrequent. BE is inflamed but the contribution of the immune system…
View article: Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis
Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis Open
View article: Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Protein Profiles that Contribute to Aggressive Malignant Behavior
Proteomic Analysis of Breast Cancer Subtypes Identifies Stromal Protein Profiles that Contribute to Aggressive Malignant Behavior Open
Breast cancer manifests as multiple subtypes with distinct patient outcomes and treatment strategies. Here, we optimized proteomic analysis of Formalin-Fixed Paraffin-Embedded (FFPE) specimens from patients diagnosed with five breast cance…
View article: Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy
Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy Open
Advanced melanoma is considered the most aggressive and deadly form of skin cancer whose incidence has been rising over the past three decades. In the absence of treatment, the median overall survival for advanced-stage metastatic disease …
View article: Studying Progression from Chronic Injury to Esophageal Adenocarcinoma
Studying Progression from Chronic Injury to Esophageal Adenocarcinoma Open
Cancer research seeks to understand the biology underlying the progression to malignant transformation. Recently, the incidence of esophageal adenocarcinoma (EAC) has increased dramatically, and if we understand why and how, we will be bet…
View article: Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon
Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon Open
View article: Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity
Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity Open
Although robustly expressed in the disease-free (DF) breast stroma, CD36 is consistently absent from the stroma surrounding invasive breast cancers (IBCs). In this study, we primarily observed CD36 expression in adipocytes and intralobular…
View article: Concerted epithelial and stromal changes during progression of Barrett’s Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis
Concerted epithelial and stromal changes during progression of Barrett’s Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis Open
Esophageal adenocarcinoma arises from Barrett’s esophagus, a precancerous metaplastic replacement of squamous by columnar epithelium in response to chronic inflammation. Multi-omics profiling, integrating single-cell transcriptomics, extra…
View article: Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition
Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition Open
These findings indicate that fibroblast associations with metaplastic epithelial cells can facilitate direct transition of metaplastic spasmolytic polypeptide-expressing metaplasia cell lineages into dysplastic lineages.
View article: Supplementary Figure 3 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Figure 3 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Supplementary Figure 3 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
View article: Supplementary Tables 1-9 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
Supplementary Tables 1-9 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues Open
PDF file - 392K, Tables S1, S2, S5, S6, S7 and S8: Patient information Table S3: LDAFs vs HDAFs microarray analysis Table S4: CD36 expression in published microarrays Table S9: Association of CD36 levels with tumor characteristics
View article: Data from p16<sup>INK4a</sup> Expression and Breast Cancer Risk in Women with Atypical Hyperplasia
Data from p16<sup>INK4a</sup> Expression and Breast Cancer Risk in Women with Atypical Hyperplasia Open
p16, a nuclear protein encoded by the p16INK4a gene, is a regulator of cell-cycle regulation. Previous studies have shown that expression of p16 in tissue biopsies of patients with ductal carcinoma in situ (DCIS) i…
View article: Data from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Data from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the synthesis of prostaglandins. Its overexpression induces numerous tumor-promoting phenotypes and is associated with cancer metastasis and poor clinical outcome. Although COX-2…
View article: Supplementary Figure Legends 1-4 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Figure Legends 1-4 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Supplementary Figure Legends 1-4 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
View article: Supplementary Figures Legends 1-8, Table Legends 1-9, Methods from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
Supplementary Figures Legends 1-8, Table Legends 1-9, Methods from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues Open
PDF file - 131K
View article: Supplementary Table 1 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Table 1 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Supplementary Table 1 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
View article: Supplementary Figures 1-8 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
Supplementary Figures 1-8 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues Open
PDF file - 1.1MB, Figure S1: Image quantitation Figure S2: Histograms of Oil Red O quantitation in LDAFs and HDAFs Figure S3: Matrix protein immunofluorescent images of LDAFs and HDAFs Figure S4: Increased and decreased expression of CD36 …
View article: Data from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
Data from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues Open
Although high mammographic density is considered one of the strongest risk factors for invasive breast cancer, the genes involved in modulating this clinical feature are unknown. Tissues of high mammographic density share key histologic fe…
View article: Supplementary Figure 4 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Figure 4 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Supplementary Figure 4 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
View article: Data from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Data from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the synthesis of prostaglandins. Its overexpression induces numerous tumor-promoting phenotypes and is associated with cancer metastasis and poor clinical outcome. Although COX-2…
View article: Supplementary Table 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Table 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Supplementary Table 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
View article: Supplementary Figures 1-8 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
Supplementary Figures 1-8 from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues Open
PDF file - 1.1MB, Figure S1: Image quantitation Figure S2: Histograms of Oil Red O quantitation in LDAFs and HDAFs Figure S3: Matrix protein immunofluorescent images of LDAFs and HDAFs Figure S4: Increased and decreased expression of CD36 …
View article: Supplementary Figures Legends 1-8, Table Legends 1-9, Methods from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues
Supplementary Figures Legends 1-8, Table Legends 1-9, Methods from CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues Open
PDF file - 131K
View article: Supplementary Figure 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Figure 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Supplementary Figure 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
View article: Supplementary Figure 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Figure 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions Open
Supplementary Figure 2 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions