Dirk Ullmann
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View article: Production of stable membrane proteins for the development of biologics
Production of stable membrane proteins for the development of biologics Open
Evotec (UK) Ltd, 2 Evotec AGThe delivery of membrane proteins in a sufficient amount and suitable quality is considered to be the bottleneck of membrane protein-based drug discovery.To overcome the challenge of expressing and purifying sta…
View article: PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B
PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B Open
A miniaturized assay was set up to test a set of natural products against protein tyrosine phosphatase 1B (PTP1B). By using several read-out and counter assays, berberine and palmatine were identified as PAINS (pan-assay interference compo…