Dominic Wichmann
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Haemophagocytic lymphohistiocytosis in critically ill adults: a single-centre retrospective ICU cohort study Open
Background Haemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterised by uncontrolled immune activation and multi-organ dysfunction. Whilst initially described in paediatric populations, HLH is…
Plasma exchange for hyperammonemia-induced reduced consciousness after PEG-asparaginase in an adult patient with acute lymphoblastic leukemia Open
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View article: Comparison of the Equivalence of <i>Aspergillus</i> Antigen and <scp>PCR</scp> Results Between Non‐Directed Bronchial Lavage and Bronchoalveolar Lavage—A Prospective Exploratory Pilot Study in Critically Ill Patients
Comparison of the Equivalence of <i>Aspergillus</i> Antigen and <span>PCR</span> Results Between Non‐Directed Bronchial Lavage and Bronchoalveolar Lavage—A Prospective Exploratory Pilot Study in Critically Ill Patients Open
Background Obtaining non‐directed samples from the upper bronchial tree is easier to perform and poses fewer risks for critically ill patients than deep bronchoalveolar lavage (BAL). Since invasive pulmonary aspergillosis is associated wit…
Outcome of critically ill patients receiving systemic chemotherapy on the intensive care unit Open
Objective Analyze the outcomes of critically ill patients who developed new-onset organ dysfunction and received systemic chemotherapy during their ICU stay. Design Retrospective cohort study. Setting A tertiary medical center in Germany w…
Economic evaluation of critically ill adult CAR-T cell recipients—analysis from a healthcare payer perspective Open
Background CAR-T cell (chimeric antigen receptor T) therapy is now part of standard of care treatment of B‑cell lineage malignancies. Although it is an effective treatment, it comes along with adverse side effects and toxicities that may r…
Gentamicin combination treatment is associated with lower mortality in patients with invasive listeriosis: a retrospective analysis Open
Purpose Listeria monocytogenes causes severe bacterial infections with the highest mortality rate among foodborne pathogens in Europe. Combination treatment with ampicillin and gentamicin is recommended for invasive manifestations. However…
Exploring European Consensus About the Remaining Treatment Challenges and Subsequent Opportunities to Improve the Management of Invasive Fungal Infection (IFI) in the Intensive Care Unit Open
Background The global prevalence of invasive fungal infections (IFI) is increasing, particularly within Intensive Care Units (ICU), where Candida spp. and Aspergillus spp. represent the most important pathogens. Diagnosis and management of…
Clinical Presentation and Outcome of Critically Ill Patients with Inflammatory Bowel Disease Open
Introduction: Admission to the intensive care unit severely affects inflammatory bowel disease (IBD) patients. This study aimed to determine factors associated with mortality in IBD patients admitted to the intensive care unit. Methods: A …
View article: Left ventricular assist device-associated driveline infections as a specific form of complicated skin and soft tissue infection/acute bacterial skin and skin structure infection – issues and therapeutic options
Left ventricular assist device-associated driveline infections as a specific form of complicated skin and soft tissue infection/acute bacterial skin and skin structure infection – issues and therapeutic options Open
Purpose of review This review comments on the current guidelines for the treatment of wound infections under definition of acute bacterial skin and skin structure infections (ABSSSI). However, wound infections around a catheter, such as dr…
Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation Open
Background Critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requiring veno-venous extracorporeal membrane oxygenation (vv-ECMO) are at risk for acute kidney injury (AKI). Currently, the incidence of…
View article: Daratumumab as rescue therapy in life-threatening granulomatosis with polyangiitis
Daratumumab as rescue therapy in life-threatening granulomatosis with polyangiitis Open
Journal Article Corrected proof Daratumumab as rescue therapy in life-threatening granulomatosis with polyangiitis Get access Martin Krusche, Martin Krusche III Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, …
Exploring European consensus about the remaining treatment challenges and subsequent opportunities to improve the management of Invasive Fungal Infection (IFI) in the Intensive Care Unit. Open
Background:The global prevalence of invasive fungal infections (IFI) is increasing, particularly within Intensive Care Units (ICU), where Candida spp. and Aspergillusspp. represent the most important pathogens. Diagnosis and management of …
Posaconazole exposure in critically ill ICU patients: a need for action Open
Purpose Posaconazole is an antifungal drug currently being used for prophylaxis and treatment of invasive fungal infections such as aspergillosis. To date, therapeutic drug monitoring (TDM) of posaconazole is recommended with the use of or…
Carbapenem-Resistant <i>Acinetobacter</i> spp Infection in Critically Ill Patients With Limited Treatment Options: A Descriptive Study of Cefiderocol Therapy During the COVID-19 Pandemic Open
Background Carbapenem-resistant Acinetobacter baumannii infections are difficult to treat and are a significant public health threat due to intrinsic/acquired resistance and limited treatment options. Methods A retrospective, observational…
View article: Rapid development of cefiderocol resistance in a carbapenem-resistant Pseudomonas aeruginosa isolate associated with mutations in the pyoverdine biosynthesis pathway
Rapid development of cefiderocol resistance in a carbapenem-resistant Pseudomonas aeruginosa isolate associated with mutations in the pyoverdine biosynthesis pathway Open
Here we report the in vivo development of cefiderocol resistance within 11 days after therapy initiation in a critically ill patient with bloodstream infection, infection of peri-anal fistula, and pneumonia caused by a VIM-2 harbouring, ca…
Clinical pharmacy services in critical care: results of an observational study comparing ward-based with remote pharmacy services Open
Background Pharmacists are essential team members in critical care and contribute to the safety of pharmacotherapy for this vulnerable group of patients, but little is known about remote pharmacy services in intensive care units (ICU). Aim…
View article: Supplementary Material for: Endoscopic and surgical management of non-metastatic ampullary neuroendocrine neoplasia: a multi-institutional Pancreas2000/EPC study
Supplementary Material for: Endoscopic and surgical management of non-metastatic ampullary neuroendocrine neoplasia: a multi-institutional Pancreas2000/EPC study Open
Introduction: Ampullary neuroendocrine neoplasia (NEN) are rare and evidence regarding their management is scarce. This study aimed to describe clinico-pathological features, management and prognosis of ampullary NEN according to their end…
View article: Supplementary Material for: Endoscopic and surgical management of non-metastatic ampullary neuroendocrine neoplasia: a multi-institutional Pancreas2000/EPC study
Supplementary Material for: Endoscopic and surgical management of non-metastatic ampullary neuroendocrine neoplasia: a multi-institutional Pancreas2000/EPC study Open
Introduction: Ampullary neuroendocrine neoplasia (NEN) are rare and evidence regarding their management is scarce. This study aimed to describe clinico-pathological features, management and prognosis of ampullary NEN according to their end…
View article: Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study
Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study Open
This study shows that among hospitalized patients with SARS-CoV-2 Omicron variant infection at risk of disease progression, treatment with sotrovimab alone or in combination with remdesivir did not decrease in-hospital mortality. These rea…
Outcomes of critically ill coronavirus disease 2019 patients requiring kidney replacement therapy: A retrospective cohort study Open
Background Coronavirus disease 2019 (COVID-19) has resulted in high hospitalization rates worldwide. Acute kidney injury (AKI) in patients hospitalized for COVID-19 is frequent and associated with disease severity and poor outcome. The aim…
View article: Molecular monitoring of T-cell kinetics and migration in severe neurotoxicity after real-world CD19-specific chimeric antigen receptor T cell therapy
Molecular monitoring of T-cell kinetics and migration in severe neurotoxicity after real-world CD19-specific chimeric antigen receptor T cell therapy Open
CD19-specific chimeric antigen receptor (CD19-CAR) T-cell therapies mediate durable responses in late-stage B-cell malignancies, but can be complicated by a potentially severe immune effector cell-associated neurotoxicity syndrome (ICANS).…
Clinical efficacy and in vitro neutralization capacity of monoclonal antibodies for severe acute respiratory syndrome coronavirus 2 delta and omicron variants Open
We aimed to provide in vitro data on the neutralization capacity of different monoclonal antibody (mAb) preparations against the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) delta and omicron variant, respectively, and desc…
View article: Comparison of four diagnostic criteria for invasive pulmonary aspergillosis—A diagnostic accuracy study in critically ill patients
Comparison of four diagnostic criteria for invasive pulmonary aspergillosis—A diagnostic accuracy study in critically ill patients Open
Background In the absence of lung biopsy, there are various algorithms for the diagnosis of invasive pulmonary aspergillosis (IPA) in critically ill patients that rely on clinical signs, underlying conditions, radiological features and myc…
View article: New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19—A Large Postmortem and Clinical Analysis
New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19—A Large Postmortem and Clinical Analysis Open
Critically ill COVID-19 patients are at high risk for venous thromboembolism (VTE), namely deep vein thrombosis (DVT) and/or pulmonary embolism (PE), and death. The optimal anticoagulation strategy in critically ill patients with COVID-19 …