D Yu Usachev
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View article: Real-Time Kinetics of Internalization of Anti-EGFR DNA Aptamers and Aptamer Constructs into Cells Derived from Glioblastoma Patients as Indicated by Doxorubicin
Real-Time Kinetics of Internalization of Anti-EGFR DNA Aptamers and Aptamer Constructs into Cells Derived from Glioblastoma Patients as Indicated by Doxorubicin Open
The WHO considers the Epidermal Growth Factor Receptor (EGFR) one of the key biomarkers of glioblastoma (GB). EGFR can be identified and targeted using molecular recognition elements (MoREs), like aptamers and aptamer–drug conjugates (ApDC…
View article: The phenomenon of long-term survival of patients with supratentorial glioblastomas: features of complex treatment and neuroimaging data
The phenomenon of long-term survival of patients with supratentorial glioblastomas: features of complex treatment and neuroimaging data Open
Background. Glioblastoma is the most common primary malignant brain tumor with an extremely unfavorable prognosis. The frequency of the “longevity” phenomenon (>3 years of overall survival – OS) in this disease is 5–10 %. The reasons for t…
Individual Brain Tumor Invasion Mapping Based on Diffusion Kurtosis Imaging Open
The developed algorithm of DKI analysis in brain tumors makes it possible to determine the degree of changes in the tissue microstructure in the perifocal zone of brain glioblastoma relative to the metastasis. The study aimed at obtaining …
In Silico Born Designed Anti-EGFR Aptamer Gol1 Has Anti-Proliferative Potential for Patient Glioblastoma Cells Open
The epidermal growth factor receptor (EGFR) is one of the key oncomarkers in glioblastoma (GB) biomedical research. High levels of EGFR expression and mutations have been found in many GB patients, making the EGFR an attractive target for …
Cerebral Ischemic Complications of Surgical Treatment in Patients with Moyamoya Disease Open
Objective: We aimed to identify unfavorable prognostic factors for the development of cerebral ischemic complications of surgical treatment in patients with moyamoya disease. Methods: We analyzed 80 patients with moyamoya disease, who unde…
Towards Aptamer-Targeted Drug Delivery to Brain Tumors: The Synthesis of Ramified Conjugates of an EGFR-Specific Aptamer with MMAE on a Cathepsin B-Cleavable Linker Open
Background/Objectives: Targeted delivery of chemotherapeutic agents is a well-established approach to cancer therapy. Antibody–drug conjugates (ADCs) typically carry toxic payloads attached to a tumor-associated antigen-targeting IgG antib…
View article: Unite and Conquer: Association of Two G-Quadruplex Aptamers Provides Antiproliferative and Antimigration Activity for Cells from High-Grade Glioma Patients
Unite and Conquer: Association of Two G-Quadruplex Aptamers Provides Antiproliferative and Antimigration Activity for Cells from High-Grade Glioma Patients Open
Background: High-grade gliomas remain a virtually incurable form of brain cancer. Current therapies are unable to completely eradicate the tumor, and the tumor cells that survive chemotherapy or radiation therapy often become more aggressi…
View article: GQIcombi application to subdue glioma via differentiation therapy
GQIcombi application to subdue glioma via differentiation therapy Open
Current therapy protocols fail to cure high-grade gliomas and prevent recurrence. Therefore, novel approaches need to be developed. A re-programing of glioma cell fate is an alternative attractive way to stop tumor growth. The two-step pro…
Amaurosis fugax due to internal carotid artery dissection during carotid chemodectoma resection Open
The article presents a clinical observation of carotid chemodectoma resection, which was complicated by amaurosis fugax and left-sided hemianopia due to dissection of internal carotid artery during surgery. The clinical symptoms manifested…
Diffusion Kurtosis Imaging and Radiomics in Diffuse Axonal Injury Open
This study aimed to assess the feasibility of radiomic features derived from diffusion kurtosis imaging (DK MRI) in identifying microstructural brain damage in diffuse axonal injury (DAI) and predicting its outcome. We hypothesized that radi…
View article: The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration
The Bi-(AID-1-T) G-Quadruplex Has a Janus Effect on Primary and Recurrent Gliomas: Anti-Proliferation and Pro-Migration Open
High-grade gliomas are considered an incurable disease. Despite all the various therapy options available, patient survival remains low, and the tumor usually returns. Tumor resistance to conventional therapy and stimulation of the migrato…
Differentiation therapy as a new multidisciplinary approach to the treatment of human brain glioma Open
Glioblastoma is among the most severe forms of neoplastic disease in the human body, with a highly unfavorable prognosis. The annual incidence of this pathology in the population is 3.5 cases per 100,000. Currently, there are no truly effe…
Magnetic Resonance Imaging in Studies of Perifocal Zone of Brain Gliomas (a Literature Review) Open
This review provides insight into application of modern MRI modalities including diffusion kurtosis imaging in assessment of perifocal glioma zone. Differentiation of “pure” perifocal vasogenic edema from edema infiltrated by glioma cells,…
The method of integral evaluation of the efficiency of the neurosurgical clinic based on the assessment of the degree of achievement of key performance indicators Open
BACKGROUND: The efficiency of a modern clinic, including neurosurgery, is traditionally assessed through the prism over a set of indicators. However, a common approach to assessing the effectiveness of medical and preventive institutions a…
Chronic Disorders of Consciousness: guidelines of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists” Open
Chronic disorders of consciousness (DOC) represent severe central nervous system damage resulting in long-term disability and a significant burden to healthcare institutions and patientsʼ families. DOC develop in patients after coma and ar…
Registration and analysis of complications in the neurosurgical clinic Open
BACKGROUND: Currently, in medicine, including neurosurgery, systemic risk management to improve treatment quality is one of the most urgent tasks. The key indicators of treatment quality in neurosurgery are the characteristics of its outco…
Perifocal Zone of Brain Gliomas: Application of Diffusion Kurtosis and Perfusion MRI Values for Tumor Invasion Border Determination Open
(1) Purpose: To determine the borders of malignant gliomas with diffusion kurtosis and perfusion MRI biomarkers. (2) Methods: In 50 high-grade glioma patients, diffusion kurtosis and pseudo-continuous arterial spin labeling (pCASL) cerebra…
Cell-Population Dynamics in Diffuse Gliomas during Gliomagenesis and Its Impact on Patient Survival Open
Diffuse gliomas continue to be an important problem in neuro-oncology. To solve it, studies have considered the issues of molecular pathogenesis from the intratumoral heterogeneity point. Here, we carried out a comparative dynamic analysis…
Russian consensus statement on the diagnosis and treatment of patients with carotid stenosis Open
Carotid stenosis is a multidisciplinary problem that requires the involvement of a specialists’ team, including cardiovascular surgeons, neurosurgeons, endovascular surgeons, cardiologists, neurologists, and internists. In this consensus s…
Stereotactic radioablation in clinical practice for the treatment of a patient with ventricular tachycardia: case report Open
The aim of the study is the demonstration of the 1 st clinical experience of stereotactic arrhythmia radioablation (STAR) of the patient with antiarrhythmic drug (AAD) refractory ventricular tachycardia (VT) in Russia. The results of STAR …
<sup>11</sup>C-methionine PET-CT in the diagnosis of anaplastic astrocytomas and anaplastic oligodendrogliomas Open
The aim of this study was to evaluate average 11 C-methionine uptake for grade II (anaplastic) gliomas in a large cohort, as well as relations between MRI and PET characteristics and their unfluence on overall and progression-free survival…
View article: First-in-Man Noninvasive Initial Diagnostic Approach of Primary CNS Lymphoma Versus Glioblastoma Using PET With 18F-Fludarabine and l-[methyl-11C]Methionine
First-in-Man Noninvasive Initial Diagnostic Approach of Primary CNS Lymphoma Versus Glioblastoma Using PET With 18F-Fludarabine and l-[methyl-11C]Methionine Open
Objectives This study sought to assess 18 F-fludarabine ( 18 F-FLUDA) PET/CT’s ability in differentiating primary central nervous system lymphomas (PCNSLs) from glioblastoma multiformes (GBMs). Patients and Methods Patients harboring eithe…
Rehabilitation in the intensive care unit (RehabICU). Clinical practice recommendations of the national Union of Physical and Rehabilitation Medicine Specialists of Russia and of the national Federation of Anesthesiologists and Reanimatologists Open
After discharge from the Intensive Care Unit (ICU), more than 50 % of patients experience pathological symptoms that are not related to the primary emergency but reduce the quality of life and require rehabilitation. Post Intensive Care Sy…
A Combined Effect of G-Quadruplex and Neuro-Inducers as an Alternative Approach to Human Glioblastoma Therapy Open
Cancer cell reprogramming based on treatment with G-quadruplex, having antiproliferative power, along with small molecules able to develop iPSCs into neurons, could create a novel approach to diminish the chance of glioblastoma recurrence …
Nosocomial meningitis laboratory criteria in ICU patients: 5-year surveillance Open
Introduction. Nosocomial meningitis (NM) is one of the leading complications in neurosurgery due to high mortality and disability rates. Objective. The study was aimed to determine the reference values of laboratory parameters to diagnose …
P04.19 A combined use of a G-quadruplex oligonucleotide (GQ) and neuro-inducing small molecules inhibit glioblastoma cell proliferation Open
BACKGROUND According to one of the theories, gliomas can occur as a result of dysregulation of stem cell division in the subventricular region of the brain. The CD133 membrane marker is a characteristic of both normal and tumor neural stem…