Daxiang Cui
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View article: AMFR-mediated ER-phagy regulation and therapeutic targeting in osteosarcoma: a multifunctional nanoplatform strategy
AMFR-mediated ER-phagy regulation and therapeutic targeting in osteosarcoma: a multifunctional nanoplatform strategy Open
This work explores how Autocrine Motility Factor Receptor (AMFR)-driven ubiquitination of Family with Sequence Similarity 134 Member B (FAM134B) in hypoxia adaptation and endoplasmic reticulum-selective autophagy (ER-phagy) in osteosarcoma…
View article: Profiling of volatile organic compounds in clinical isolate cultures and stools from children with <i>Clostridioides difficile</i> infection by HS-SPME-GC-MS
Profiling of volatile organic compounds in clinical isolate cultures and stools from children with <i>Clostridioides difficile</i> infection by HS-SPME-GC-MS Open
Bacterial volatile organic compounds (VOCs) have been investigated as a non-invasive approach to diagnosis of infectious diseases. Here, we aimed to explore potential diagnostic markers by profiling VOCs in cultures of unique clinical Clos…
View article: Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization, and bleeding is a major defect in Alzheimer’s disease
Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization, and bleeding is a major defect in Alzheimer’s disease Open
JOURNAL/nrgr/04.03/01300535-202602000-00047/figure1/v/2025-05-17T081902Z/r/image-tiff Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-β deposits in brain blood vessels, microaneurysms, and senile plaques. How am…
View article: Nanoparticle-based Traditional Chinese Medicine for Immunotherapy in Gastrointestinal Tumors
Nanoparticle-based Traditional Chinese Medicine for Immunotherapy in Gastrointestinal Tumors Open
The combination of traditional Chinese medicine (TCM) nanoparticles with modern immunotherapy presents a promising approach to enhancing the treatment of gastrointestinal tumors. TCM nanoparticles can significantly augment the efficacy of …
View article: Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition
Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition Open
Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 na…
View article: Microfluidic-based electrically driven particle manipulation techniques for biomedical applications
Microfluidic-based electrically driven particle manipulation techniques for biomedical applications Open
Microfluidic chips exhibit unique advantages in both economy and rapidity, particularly for the separation and detection of biomolecules.
View article: Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC)
Nanoparticle-based drug delivery systems: opportunities and challenges in the treatment of esophageal squamous cell carcinoma (ESCC) Open
Nanoparticles boost ESCC treatment efficacy by enhancing drug targeting and overcoming biological barriers, despite biocompatibility and scalability challenges.
View article: Nanomedicine breakthroughs overcoming pancreatic cancer drug resistance through precision nano-interventions
Nanomedicine breakthroughs overcoming pancreatic cancer drug resistance through precision nano-interventions Open
Stimuli-responsive nanocarriers tailored to bypass efflux pumps, target cancer stem cells, and remodel the stroma overcome PDAC resistance and enhance therapeutic efficacy.
View article: Wearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism
Wearable Temperature Sensor Enhanced Volatilomics Technique for Swift and Convenient Detection of Latrogenic Botulism Open
Accurately assessing potential side effects following botulinum neurotoxin (BoNT) injection remains a formidable challenge. To address this issue, an innovative approach is developed that combines a wearable temperature sensor with a sophi…
View article: Unlocking Pan-Cancer Detection with Phenyl-β-D-Glucuronide Like Exogenous Agent and Induced Breath Analysis for Non-Invasive Early Discovery
Unlocking Pan-Cancer Detection with Phenyl-β-D-Glucuronide Like Exogenous Agent and Induced Breath Analysis for Non-Invasive Early Discovery Open
The urgent need for a non-invasive, universally applicable cancer detection method has never been more critical. In response to the pressing demand, we presents the discovery of phenyl-β-D-glucuronide, a natural compound, for tumor detecti…
View article: A Multifunctional Low-Temperature Photothermal Nanomedicine for Melanoma Treatment via the Oxidative Stress Pathway Therapy
A Multifunctional Low-Temperature Photothermal Nanomedicine for Melanoma Treatment via the Oxidative Stress Pathway Therapy Open
GNR@PEG-Qu nanoagent exhibits synergistic treatment and high tumor inhibition effects, which is a promising strategy developed to achieve oxidative stress avoidance and synergistic therapy of melanoma using quercetin (Qu)-coated gold nanor…
View article: Ambient energy harvesters in wearable electronics: fundamentals, methodologies, and applications
Ambient energy harvesters in wearable electronics: fundamentals, methodologies, and applications Open
In recent years, wearable sensor devices with exceptional portability and the ability to continuously monitor physiological signals in real time have played increasingly prominent roles in the fields of disease diagnosis and health managem…
View article: Intelligent cardiovascular disease diagnosis system combined piezoelectric nanogenerator based on 2D Bi2O2Se with deep learning technique
Intelligent cardiovascular disease diagnosis system combined piezoelectric nanogenerator based on 2D Bi2O2Se with deep learning technique Open
Two-dimensional (2D) piezoelectric nanogenerators (PENGs) have great potential in capturing weak physiological signals on the body surface due to their superior flexibility and high sensitivity. However, there are few reports on utilizing …
View article: Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer’s disease
Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer’s disease Open
Alzheimer’s disease (AD) is a multi-amyloidosis disease with Aβ deposits in the cerebral blood vessels, microaneurysms and senile plaques. How Aβ amyloidosis affects axon pathology is not well-examined. We studied Aβ-related axonal phenoty…
View article: Flexible polydimethylsiloxane pressure sensor with micro-pyramid structures and embedded silver nanowires: A novel application in urinary flow measurement
Flexible polydimethylsiloxane pressure sensor with micro-pyramid structures and embedded silver nanowires: A novel application in urinary flow measurement Open
Flexible pressure sensors are lightweight and highly sensitive, making them suitable for use in small portable devices to achieve precise measurements of tiny forces. This article introduces a low-cost and easy-fabrication strategy for pie…
View article: hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study
hUC-MSCs therapy for Crohn’s disease: efficacy in TNBS-induced colitis in rats and pilot clinical study Open
This work was funded by General Program of National Natural Science Foundation of China (Grant No. 82270639), the Scientific research project of Shanghai Municipal Health Committee (Grant No. 202240001), Specialty Feature Construction Proj…
View article: Erythrocyte Membrane Camouflaged Nanotheranostics for Optical Molecular Imaging‐Escorted Self‐Oxygenation Photodynamic Therapy
Erythrocyte Membrane Camouflaged Nanotheranostics for Optical Molecular Imaging‐Escorted Self‐Oxygenation Photodynamic Therapy Open
Hypoxic tumor microenvironment (TME) hampers the application of oxygen (O 2 )‐dependent photodynamic therapy (PDT) in solid tumors. To address this problem, a biomimetic nanotheranostics (named MMCC@EM) is developed for optical molecular i…
View article: Discovery of Phenyl-β-D-glucuronide Medical Function for in Vivo Producing Handheld Gas Sensor Detectable Phenol-like Breath Marker: The Future of Induced Volatolomics in Cancer Risk Pre-warning
Discovery of Phenyl-β-D-glucuronide Medical Function for in Vivo Producing Handheld Gas Sensor Detectable Phenol-like Breath Marker: The Future of Induced Volatolomics in Cancer Risk Pre-warning Open
Induced volatolomics provides a promising approach for cancer risk pre-warning. Nevertheless, continues to be questioned bio-compatibility of the synthetic exogenous agents and sophisticated instrument solely detectable isotopes labeled vo…
View article: Advances and Prospects in Integrated Nano-oncology
Advances and Prospects in Integrated Nano-oncology Open
In recent years, the deep integration of basic research and clinical translational research of nanotechnology and oncology has led to the emergence of a new branch, namely integrated nano-oncology. This is an emerging and important interdi…
View article: Investigation of the Viability of Cells upon Co-Exposure to Gold and Iron Oxide Nanoparticles
Investigation of the Viability of Cells upon Co-Exposure to Gold and Iron Oxide Nanoparticles Open
Cell\nlines were exposed either to mixtures of gold and iron oxide\nnanoparticles, or to a hybrid nanoparticle with gold and iron oxide\ndomain. In the case of simultaneous exposure to gold and iron oxide\nnanoparticles, enhanced toxicity …
View article: UV-assisted synthesis of ultra-small GO–Austar for efficient PTT therapeutic architectonic construction
UV-assisted synthesis of ultra-small GO–Austar for efficient PTT therapeutic architectonic construction Open
UV-assisted synthesis GO–Austar complexes accomplished synergistic gastric cancer photothermal therapy.
View article: AI‐Driven Wearable Mask‐Inspired Self‐Healing Sensor Array for Detection and Identification of Volatile Organic Compounds
AI‐Driven Wearable Mask‐Inspired Self‐Healing Sensor Array for Detection and Identification of Volatile Organic Compounds Open
Volatile organic compounds (VOCs) sensor arrays have garnered considerable attention due to their potential to provide real‐time information for monitoring pollution levels and personal health associated concerning VOCs in the ambient envi…