Dawei Geng
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View article: Low-Cost Biomass Nanofibers from Chitosan and Phytic Acid for Efficient Uranium Extraction
Low-Cost Biomass Nanofibers from Chitosan and Phytic Acid for Efficient Uranium Extraction Open
Exploring materials for the uranium extraction from seawater holds great significance for the sustainable development of the nuclear industry. Though many adsorbents have been investigated to extract uranium, they still suffer from the iss…
View article: Regulation of gene expression by FOXA1
Regulation of gene expression by FOXA1 Open
The forkhead box (FOX) family represents a class of transcription factors characterized by a distinctive winged helical structure. Forkhead box A1 (FOXA1), a member of the forkhead box A (FOXA) subfamily within the FOX gene family, was the…
View article: The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in Osteoarthritis
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in Osteoarthritis Open
BACKGROUND The pathological mechanism of osteoarthritis is still unclear. The regulation of the immune microenvironment has been of growing interest in the progression and treatment of osteoarthritis. Macrophages with different phenotypes,…
View article: Hepatocellular Carcinoma Overcomes Lipid Depletion by Utilizing Serine for Phospholipid Synthesis and Enhanced Survival
Hepatocellular Carcinoma Overcomes Lipid Depletion by Utilizing Serine for Phospholipid Synthesis and Enhanced Survival Open
Metabolic vulnerabilities of hepatocellular carcinoma (HCC) remain largely unexplored, though deregulation in these processes is a hallmark of cancer. HCC cells exhibit a marked dependence on lipids and have distinct responses to lipid dep…
View article: Design and synthesis of novel N-methyl-N-(2,4,6-trimethoxybenzyl)cinnamamide derivatives as CrtN inhibitors for treatment of infectious diseases
Design and synthesis of novel N-methyl-N-(2,4,6-trimethoxybenzyl)cinnamamide derivatives as CrtN inhibitors for treatment of infectious diseases Open
CrtN has been identified as an appealing target for treatment of pigmented staphylococcus aureus infections. A novel of N-methyl-N-(2,4,6-trimethoxybenzyl)cinnamamide derivatives as CrtN inhibitors based on the structure of naftifine (NTF)…
View article: Local Drug-Induced Modulation of gp130 Receptor Signaling Delays Disease Progression in a Pig Model of Temporo-Mandibular Joint Osteoarthritis
Local Drug-Induced Modulation of gp130 Receptor Signaling Delays Disease Progression in a Pig Model of Temporo-Mandibular Joint Osteoarthritis Open
Temporomandibular joint disorders (TMJs) are a multifaceted group of chronic disorders characterized by stiffness in the jaw, limited jaw mobility and pain when opening or closing the mouth. TMJs are relatively common, with incidence rates…
View article: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes
gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes Open
Growth of long bones and vertebrae is maintained postnatally by a long-lasting pool of progenitor cells. Little is known about the molecular mechanisms that regulate the output and maintenance of the cells that give rise to mature cartilag…
View article: Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes Open
Osteoarthritis (OA) impacts hundreds of millions of people worldwide, with those affected incurring significant physical and financial burdens. Injuries such as focal defects to the articular surface are a major contributing risk factor fo…
View article: Quantitative genome-scale analysis of human liver reveals dysregulation of glycosphingolipid pathways in progressive nonalcoholic fatty liver disease
Quantitative genome-scale analysis of human liver reveals dysregulation of glycosphingolipid pathways in progressive nonalcoholic fatty liver disease Open
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is associated with multiple metabolic disturbances, yet the metabolic pathways underlying its progression are poorly understood. Here we studied metabolic p…
View article: Short-Term Wind Speed Prediction Based on Principal Component Analysis and LSTM
Short-Term Wind Speed Prediction Based on Principal Component Analysis and LSTM Open
An accurate prediction of wind speed is crucial for the economic and resilient operation of power systems with a high penetration level of wind power. Meteorological information such as temperature, humidity, air pressure, and wind level h…
View article: Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes
Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes Open
In the last decade, increasing incidence of type 1 diabetes (T1D) stabilized in Finland, a phenomenon that coincides with tighter regulation of perfluoroalkyl substances (PFAS). Here, we quantified PFAS to examine their effects, during pre…
View article: 7,8‑Dihydroxyflavone activates Nrf2/HO‑1 signaling pathways and protects against osteoarthritis
7,8‑Dihydroxyflavone activates Nrf2/HO‑1 signaling pathways and protects against osteoarthritis Open
The aim of the present study was to investigate the effect of 7,8-dihydroxyflavone (7,8-DHF) against osteoarthritis (OA) and examine its regulatory role in the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway in chondro…
View article: Towards Practical Lipschitz Stochastic Bandits
Towards Practical Lipschitz Stochastic Bandits Open
Stochastic Lipschitz bandit algorithms are methods that govern
exploration-exploitation tradeoffs, and have been used for a variety of
important task domains, including zeroth order optimization. While beautiful
theory has been developed f…
View article: A Practical Bandit Method with Advantages in Neural Network Tuning.
A Practical Bandit Method with Advantages in Neural Network Tuning. Open
Stochastic bandit algorithms can be used for challenging non-convex optimization problems. Hyperparameter tuning of neural networks is particularly challenging, necessitating new approaches. To this end, we present a method that adaptively…
View article: 42.3 METABOLOMICS APPROACHES TO STUDY METABOLIC CO-MORBIDITIES IN PSYCHOTIC DISORDERS
42.3 METABOLOMICS APPROACHES TO STUDY METABOLIC CO-MORBIDITIES IN PSYCHOTIC DISORDERS Open
Psychotic patients are at high risk for developing obesity, metabolic syndrome and type 2 diabetes. These metabolic co-morbidities are hypothesized to be related to both treatment side-effects as well as to metabolic changes occurring duri…
View article: MMC controlled-release membranes attenuate epidural scar formation in rat models after laminectomy
MMC controlled-release membranes attenuate epidural scar formation in rat models after laminectomy Open
Epidural scar formation after laminectomy impede surgical outcomes of decompression. Mitomycin C (MMC) has been demonstrated to have significant inhibitory effects on epidural scar. This study was undertaken to develop an effective MMC con…
View article: Gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry methods for the determination of environmental contaminants
Gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry methods for the determination of environmental contaminants Open
The recent developments and improvements of instrumental methods for the analyses of the environmental contaminants, especially the persistent organic pollutants (POPs), have made it possible to detect and quantify these at very low concen…
View article: Atmospheric-Pressure Chemical Ionization Tandem Mass Spectrometry (APGC/MS/MS) an Alternative to High-Resolution Mass Spectrometry (HRGC/HRMS) for the Determination of Dioxins
Atmospheric-Pressure Chemical Ionization Tandem Mass Spectrometry (APGC/MS/MS) an Alternative to High-Resolution Mass Spectrometry (HRGC/HRMS) for the Determination of Dioxins Open
The use of a new atmospheric-pressure chemical ionization source for gas chromatography (APGC) coupled with a tandem quadrupole mass spectrometry (MS/MS) system, as an alternative to high-resolution mass spectrometry (HRMS), for the determ…