Danian Chen
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View article: Automated registration of spatial expression data scales multimodal integration to large cohorts
Automated registration of spatial expression data scales multimodal integration to large cohorts Open
Recent advances in spatial proteomics enable quantification of the spatial distribution of protein expression across a variety of scales, resolutions, and multiplexing. Registering images from such technologies across modalities is an esse…
View article: Cell cycle duration determines oncogenic transformation capacity
Cell cycle duration determines oncogenic transformation capacity Open
Oncogenic mutations are widespread in normal human tissues1. Similarly, in murine chimeras, cells carrying an oncogenic lesion contribute normal cells to adult tissues without causing cancer2-4. How lineages that escape cancer via normal d…
View article: The gut microbiota regulates diabetic retinopathy in adult rats
The gut microbiota regulates diabetic retinopathy in adult rats Open
Introduction Diabetic retinopathy (DR) is the most common complication of diabetes. Neuronal apoptosis, activated microglia, and microvascular changes are early features of DR. The gut microbiota is critical for the maturation and activati…
View article: A high-fat plus high-sucrose diet induces age-related macular degeneration in an experimental rabbit model
A high-fat plus high-sucrose diet induces age-related macular degeneration in an experimental rabbit model Open
Age-related macular degeneration (AMD) is a leading cause of blindness. Metabolic disorders and diets are risk factors. We compared lipid profiles and retinal phenotypes with long-term feeding of four diets in male Chinchilla rabbits. Anim…
View article: Hyperglycemia-independent neonatal streptozotocin-induced retinopathy (NSIR) in rats
Hyperglycemia-independent neonatal streptozotocin-induced retinopathy (NSIR) in rats Open
Introduction: Chemicals, such as MNU (N-methyl-N-nitrosourea) and NaIO3 (sodium iodate), are widely used to induce retinal degeneration in rodents. Streptozotocin (STZ) is an analog of N-acetyl glucosamine in which an MNU moiety is linked …
View article: Endophthalmitis: a bibliometric study and visualization analysis from 1993 to 2023
Endophthalmitis: a bibliometric study and visualization analysis from 1993 to 2023 Open
Aims This study is designed to generalize and depict the research hotspots of endophthalmitis through bibliometric methods and software and analyze the evolutive tendency of the work on this severe disease over the past 30 years. Methods T…
View article: Beyond the Cox Hazard Ratio: A Targeted Learning Approach to Survival Analysis in a Cardiovascular Outcome Trial Application
Beyond the Cox Hazard Ratio: A Targeted Learning Approach to Survival Analysis in a Cardiovascular Outcome Trial Application Open
The Hazard Ratio (HR) is a well-established treatment effect measure in randomized trials involving right-censored time-to-events, and the Cardiovascular Outcome Trials (CVOTs) conducted since the FDA’s 2008 guidance have indeed largely ev…
View article: Reduced macular thickness and vascular density in abnormal glucose metabolism patients: A meta-analysis of optical coherence tomography (OCT) and OCT angiography studies
Reduced macular thickness and vascular density in abnormal glucose metabolism patients: A meta-analysis of optical coherence tomography (OCT) and OCT angiography studies Open
Background: Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy (DR) remain inconclusive. This study aimed to determine whether retinal manifestations in abnormal glucose metabolism (AGM) pa…
View article: Development and clinical validation of a Potential Penside Colorimetric LAMP Assay of Porcine Circovirus type 3
Development and clinical validation of a Potential Penside Colorimetric LAMP Assay of Porcine Circovirus type 3 Open
OBJECTIVES: Porcine circovirus type 3 (PCV3), a novel circovirus, imposes great burdens on the global pig industry. The penside tests for detecting PCV3 are critical for assessing the epidemiological status and adjusting disease prevention…
View article: The role of the microbiota in glaucoma
The role of the microbiota in glaucoma Open
Glaucoma is a common irreversible vision loss disorder because of the gradual loss of retinal ganglion cells (RGCs) and the optic nerve axons. Major risk factors include elder age and high intraocular pressure (IOP). However, high IOP is n…
View article: Gut microbiota and eye diseases: a bibliometric study and visualization analysis
Gut microbiota and eye diseases: a bibliometric study and visualization analysis Open
Introduction Recently the role of gut microbial dysbiosis in many ocular disorders, including but not limited to uveitis, age-related macular degeneration (AMD), diabetic retinopathy (DR), dry eye, keratitis and orbitopathy is a hot resear…
View article: The heterogeneity of astrocytes in glaucoma
The heterogeneity of astrocytes in glaucoma Open
Glaucoma is a leading cause of blindness with progressive degeneration of retinal ganglion cells. Aging and increased intraocular pressure (IOP) are major risk factors. Lowering IOP does not always stop the disease progression. Alternative…
View article: A Naked-Eye Visual Reverse Transcription Loop-Mediated Isothermal Amplification with Sharp Color Changes for Potential Pen-Side Test of Foot-and-Mouth Disease Virus
A Naked-Eye Visual Reverse Transcription Loop-Mediated Isothermal Amplification with Sharp Color Changes for Potential Pen-Side Test of Foot-and-Mouth Disease Virus Open
Visual loop-mediated isothermal amplification (LAMP) is qualified to be applied in the field to detect pathogens due to its simplicity, rapidity and cost saving. However, the color changes in currently reported visual reverse transcription…
View article: <i>In vivo</i> base editing rescues photoreceptors in a mouse model of retinitis pigmentosa
<i>In vivo</i> base editing rescues photoreceptors in a mouse model of retinitis pigmentosa Open
Retinitis pigmentosa (RP) is a group of retinal diseases that cause the progressive death of retinal photoreceptor cells and eventually blindness. Mutations in the β-domain of the phosphodiesterase 6 ( Pde6b ) gene are among the most ident…
View article: Identification of a De Novo Heterozygous Missense ACTB Variant in Baraitser–Winter Cerebrofrontofacial Syndrome
Identification of a De Novo Heterozygous Missense ACTB Variant in Baraitser–Winter Cerebrofrontofacial Syndrome Open
Baraitser–Winter cerebrofrontofacial syndrome (BWCFF, OMIM: 243310) is a rare autosomal-dominant developmental disorder associated with variants in the genes ACTB or ACTG1 . It is characterized by brain malformations, a distinctive facial …
View article: DNA Methylation Aberrant in Atherosclerosis
DNA Methylation Aberrant in Atherosclerosis Open
Atherosclerosis (AS) is a pathological process involving lipid oxidation, immune system activation, and endothelial dysfunction. The activated immune system could lead to inflammation and oxidative stress. Risk factors like aging and hyper…
View article: Steroid Treatment in Macular Edema: A Bibliometric Study and Visualization Analysis
Steroid Treatment in Macular Edema: A Bibliometric Study and Visualization Analysis Open
The use of steroids to treat macular edema (ME) is a research hotspot in ophthalmology. We utilized CiteSpace and VOSviewer software to evaluate the Web of Science Core Collection publications and to build visualizing maps to describe the …
View article: Development and Clinical Validation of a Potential Penside Colorimetric Loop-Mediated Isothermal Amplification Assay of Porcine Circovirus Type 3
Development and Clinical Validation of a Potential Penside Colorimetric Loop-Mediated Isothermal Amplification Assay of Porcine Circovirus Type 3 Open
Porcine circovirus type 3 (PCV3), a novel circovirus, imposes great burdens on the global pig industry. The penside tests for detecting PCV3 are critical for assessing the epidemiological status and working out disease prevention and contr…
View article: The Role of the Microbiota in Graves’ Disease and Graves’ Orbitopathy
The Role of the Microbiota in Graves’ Disease and Graves’ Orbitopathy Open
Graves‘ disease (GD) is a clinical syndrome with an enlarged and overactive thyroid gland, an accelerated heart rate, Graves’ orbitopathy (GO), and pretibial myxedema (PTM). GO is the most common extrathyroidal complication of GD. GD/GO ha…
View article: Mapping Transgene Insertion Sites Reveals the α-Cre Transgene Expression in Both Developing Retina and Olfactory Neurons
Mapping Transgene Insertion Sites Reveals the α-Cre Transgene Expression in Both Developing Retina and Olfactory Neurons Open
The Tg(Pax6-cre,GFP)2Pgr (α-Cre) mouse (MGI:3052661) is a commonly used Cre line thought to be retinal-specific. Using targeted locus amplification (TLA), we mapped the insertion site of the transgene, and defined primers useful to deduce …
View article: Clinical Pathological Features and Current Animal Models of Type 3 Macular Neovascularization
Clinical Pathological Features and Current Animal Models of Type 3 Macular Neovascularization Open
Type 3 macular neovascularization (MNV3), or retinal angiomatous proliferation (RAP), is a distinct type of neovascular age-related macular degeneration (AMD), which is a leading cause of vision loss in older persons. During the past decad…
View article: InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes
InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes Open
The mouse eye is used to model central nervous system development, pathology, angiogenesis, tumorigenesis, and regenerative therapies. To facilitate the analysis of these processes, we developed an optimized tissue clearing and depigmentat…
View article: Ballistic impact response of resistance-spot-welded (RSW) double-layered plates for Q&P980 steel
Ballistic impact response of resistance-spot-welded (RSW) double-layered plates for Q&P980 steel Open
Ballistic impact response of resistance-spot-welded (RSW) double-layered (2 × 1.6 mm) plates (190 mm × 150 mm) for Q&P980 steel impacted by a round-nosed steel bullet (12 mm diameter and 30 mm length) was investigated by using gas gun and …
View article: Interaction Between Mesenchymal Stem Cells and Retinal Degenerative Microenvironment
Interaction Between Mesenchymal Stem Cells and Retinal Degenerative Microenvironment Open
Retinal degenerative diseases (RDDs) are a group of diseases contributing to irreversible vision loss with yet limited therapies. Stem cell-based therapy is a promising novel therapeutic approach in RDD treatment. Mesenchymal stromal/stem …
View article: Upregulated Long Non-Coding RNA LL22NC03-N64E9.1 Promotes the Proliferation and Migration of Human Breast Cancer Cells by Silencing Kruppel-Like Factor 2 Expression
Upregulated Long Non-Coding RNA LL22NC03-N64E9.1 Promotes the Proliferation and Migration of Human Breast Cancer Cells by Silencing Kruppel-Like Factor 2 Expression Open
Weibin Lian,1,* Xiaohua Jiang,2,* Liangqiang Li,1,* Qinglan Wang,1 Chengye Hong,1 Peidong Yang,1 Debo Chen1 1Department of Breast Surgery, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, People&rsquo;…
View article: Prevalence of meibomian gland dysfunction in staffs and faculty members of a Chinese university
Prevalence of meibomian gland dysfunction in staffs and faculty members of a Chinese university Open
The prevalence of MGD in staffs and faculty members of a Chinese university is 32.3%, and increases with age.
View article: The Role of Gut Microbiome in Autoimmune Uveitis
The Role of Gut Microbiome in Autoimmune Uveitis Open
The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a …