Cristiano de Pádua Souza
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View article: Impact of public vs. private insurance coverage on quality of life of women with early-stage estrogen receptor-positive breast cancer
Impact of public vs. private insurance coverage on quality of life of women with early-stage estrogen receptor-positive breast cancer Open
In this cohort, patients treated at public institutions had lower QOL. Younger age (< 60 years), presence of comorbidities, and ovarian suppression associated with ET were key predictors of poor QOL. These findings provide insights for gui…
View article: Employment Status Among Brazilian Women With Estrogen Receptor‐Positive Nonmetastatic Breast Cancer
Employment Status Among Brazilian Women With Estrogen Receptor‐Positive Nonmetastatic Breast Cancer Open
Background Employment is a critical determinant of quality of life, social reintegration, and financial stability for breast cancer survivors. International studies have shown that return‐to‐work (RTW) rates vary widely, ranging from 27% t…
View article: Cancer Health Disparities Among Patients With Early-Stage Estrogen Receptor–Positive Breast Cancer: Impact of Public Versus Private Health Care on Diagnosis-to-Treatment Interval in Brazil
Cancer Health Disparities Among Patients With Early-Stage Estrogen Receptor–Positive Breast Cancer: Impact of Public Versus Private Health Care on Diagnosis-to-Treatment Interval in Brazil Open
PURPOSE In 2013, Brazil implemented a federal law (Law 12.732/2012) mandating cancer treatment to begin within 60 days of diagnosis. Among women with newly diagnosed estrogen receptor–positive (ER+) nonmetastatic breast cancer, we describe…
View article: Predicting Symptomatic Cardiotoxicity in HER2-Positive Breast Cancer Patients Treated with Trastuzumab: Insights from a Brazilian Real-World Cohort
Predicting Symptomatic Cardiotoxicity in HER2-Positive Breast Cancer Patients Treated with Trastuzumab: Insights from a Brazilian Real-World Cohort Open
Background Cardiotoxicity is a known adverse effect of Trastuzumab treatment. Early detection through regular cardiac imaging is crucial to prevent its progression and ensure reversibility. However, recent studies question the current card…
View article: Transcriptomic Profiling of Paired Primary Tumors and CNS Metastases in Breast Cancer Reveals Immune Modulation Signatures
Transcriptomic Profiling of Paired Primary Tumors and CNS Metastases in Breast Cancer Reveals Immune Modulation Signatures Open
Breast cancer is a leading cause of central nervous system (CNS) metastases in women, often associated with poor prognosis and limited therapeutic options. However, molecular differences between primary tumors and CNS metastases remain und…
View article: Metformin for the treatment of breast cancer: a scoping review of randomized clinical trials
Metformin for the treatment of breast cancer: a scoping review of randomized clinical trials Open
Metformin has been the focus of substantial interest in the field of oncology. Although breast cancer is the type of cancer where metformin was most extensively-studied through randomized clinical trials (RCTs), none of the previous review…
View article: Key drivers of non-revenue water in developing countries: Insights from a multilevel study in Brazil
Key drivers of non-revenue water in developing countries: Insights from a multilevel study in Brazil Open
The increasing pressure on water resources has intensified the need to improve water supply efficiency, particularly by minimizing water loss. Non-revenue water (NRW) remains a critical issue in Brazil, with high loss levels impacting both…
View article: Adherence to Adjuvant Endocrine Therapy in Patients With Nonmetastatic Estrogen Receptor–Positive Breast Cancer: A Comprehensive Brazilian Real-World Data Study
Adherence to Adjuvant Endocrine Therapy in Patients With Nonmetastatic Estrogen Receptor–Positive Breast Cancer: A Comprehensive Brazilian Real-World Data Study Open
PURPOSE Adjuvant endocrine therapy (ET) improves the prognosis of patients with nonmetastatic estrogen receptor–positive (ER+) breast carcinoma; however, adherence is crucial to ensure its efficacy. In Brazil, data regarding adherence to E…
View article: Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients
Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients Open
The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment…
View article: Antibody-Drug Conjugates in Breast Cancer: A Comprehensive Review of How to Selectively Deliver Payloads
Antibody-Drug Conjugates in Breast Cancer: A Comprehensive Review of How to Selectively Deliver Payloads Open
Antibody-drug conjugates (ADCs) have surfaced as a promising group of anticancer agents employing the precise targeting capacity of monoclonal antibodies to transport highly effective cytotoxic payloads. Compared to conventional chemothera…
View article: Evaluation of upper limb lymphoedema and diagnostic accuracy of bioimpedance spectroscopy. A comprehensive validation in a Brazilian population
Evaluation of upper limb lymphoedema and diagnostic accuracy of bioimpedance spectroscopy. A comprehensive validation in a Brazilian population Open
Although BIS was significantly associated with the subjective evaluation of lymphoedema, it showed low sensitivity and agreement and moderate correlation when used as a method for diagnosing the condition. Thus, it is not the most valid me…
View article: Neoadjuvant carboplatin in triple-negative breast cancer: results from NACATRINE, a randomized phase II clinical trial
Neoadjuvant carboplatin in triple-negative breast cancer: results from NACATRINE, a randomized phase II clinical trial Open
Background Neoadjuvant chemotherapy (NACT) is the mainstay of treatment of stages II and III triple-negative breast cancer (TNBC). This study aims to evaluate if the addition of carboplatin to NACT is associated with an increase in the pat…
View article: Discrepancies in breast cancer’s oncological outcomes between public and private institutions in the southeast region of Brazil: a retrospective cohort study
Discrepancies in breast cancer’s oncological outcomes between public and private institutions in the southeast region of Brazil: a retrospective cohort study Open
Background Brazil is a middle-income country with inequalities in its healthcare system. The disparities between public and private services affect the diagnosis and treatment of patients with breast cancer. The aim of this study is to ass…
View article: Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review
Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review Open
Ovarian germ cell tumors (OGCTs) are rare in adults; indeed, they occur predominantly in children, adolescents, and young adults, and they account for approximately 11% of cancer diagnoses in these groups. Because OGCTs are rare tumors, ou…
View article: Neoadjuvant carboplatin in triple-negative breast cancer: results from NACATRINE, a randomized phase II clinical trial
Neoadjuvant carboplatin in triple-negative breast cancer: results from NACATRINE, a randomized phase II clinical trial Open
Background Neoadjuvant chemotherapy (NACT) is the mainstay of treatment of stages II and III triple-negative breast cancer (TNBC). There is interest in the addition of carboplatin to NACT, especially in TNBC patients with germline BRCA mut…
View article: Management of patients with recurrent/metastatic endometrial cancer: Consensus recommendations from an expert panel from Brazil
Management of patients with recurrent/metastatic endometrial cancer: Consensus recommendations from an expert panel from Brazil Open
Background Endometrial cancer is of increasing concern in several countries, including Brazil, in part because of an ageing population, declines in fertility, and the increasing prevalence of obesity. Although endometrial tumors had lagged…
View article: Quality of life in Brazilian women with early breast cancer on adjuvant endocrine therapy
Quality of life in Brazilian women with early breast cancer on adjuvant endocrine therapy Open
Objective: This study aimed to evaluate the quality of life (QOL) in women with early breast cancer treated with adjuvant endocrine therapy and to explore its relationships with patients’ clinical and social characteristics, type and time …
View article: Evaluation of upper limb lymphedema using spectroscopic bioimpedance in a Brazilian population
Evaluation of upper limb lymphedema using spectroscopic bioimpedance in a Brazilian population Open
Objective: Upper limb lymphedema secondary to breast cancer treatment is a disabling, chronic, and often incurable sequel, resulting from lymphatic insufficiency. There are several methodologies for diagnosing lymphedema, such as volumetri…
View article: Adherence to endocrine adjuvant therapy in women with early hormone-positive breast cancer
Adherence to endocrine adjuvant therapy in women with early hormone-positive breast cancer Open
Objective: This study aimed to evaluate adherence to adjuvant endocrine therapy in women with early breast cancer and explore its relationships with patients’ clinical and social characteristics and site of treatment. Methodology: Women wi…
View article: Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer
Liquid Biopsy as a Tool for the Diagnosis, Treatment, and Monitoring of Breast Cancer Open
Breast cancer (BC) is a highly heterogeneous disease. The treatment of BC is complicated owing to intratumoral complexity. Tissue biopsy and immunohistochemistry are the current gold standard techniques to guide breast cancer therapy; howe…
View article: Molecular Biomarkers Predict Pathological Complete Response of Neoadjuvant Chemotherapy in Breast Cancer Patients: Review
Molecular Biomarkers Predict Pathological Complete Response of Neoadjuvant Chemotherapy in Breast Cancer Patients: Review Open
Neoadjuvant chemotherapy (NAC) is often used to treat locally advanced disease for tumor downstaging, thus improving the chances of breast-conserving surgery. From the NAC response, it is possible to obtain prognostic information as patien…