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View article: Photobiomodulation Therapy Moderates Cancer Cachexia-associated Muscle wasting through Activating PI3K/AKT/FoxO3a Pathway succinct title: PBMT Alleviates Muscle Wasting via PI3K/AKT/FoxO3a Pathway
Photobiomodulation Therapy Moderates Cancer Cachexia-associated Muscle wasting through Activating PI3K/AKT/FoxO3a Pathway succinct title: PBMT Alleviates Muscle Wasting via PI3K/AKT/FoxO3a Pathway Open
Cancer cachexia-associated muscle wasting as a multifactorial wasting syndrome, is an important factor affecting the long-term survival rate of tumor patients. Photobiomodulation therapy (PBMT) has emerged as a promising tool to cure and p…
View article: Data from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
Data from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway Open
The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division. Aur-A dysregulation represents an oncogenic event that promotes tumor formation. Here, we report t…
View article: Supplementary Figures 1-8, Tables 1-3, Methods from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
Supplementary Figures 1-8, Tables 1-3, Methods from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway Open
Supplementary Figures 1-8, Tables 1-3, Methods from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
View article: Supplementary Figures 1-8, Tables 1-3, Methods from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
Supplementary Figures 1-8, Tables 1-3, Methods from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway Open
Supplementary Figures 1-8, Tables 1-3, Methods from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
View article: Data from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
Data from The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway Open
The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division. Aur-A dysregulation represents an oncogenic event that promotes tumor formation. Here, we report t…
View article: Label free visualization of amyloid plaques in Alzheimer's disease with polarization-sensitive photoacoustic Mueller matrix tomography
Label free visualization of amyloid plaques in Alzheimer's disease with polarization-sensitive photoacoustic Mueller matrix tomography Open
The formation of amyloid plaques in the cortical and hippocampal brain regions caused by abnormal deposition of extracellular amyloid \b{eta}-protein (A\b{eta}) is a characteristic pathological hallmark of early Alzheimer's disease (AD), w…
View article: Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β‐amyloid load in Alzheimer's disease model
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β‐amyloid load in Alzheimer's disease model Open
Inducing gamma oscillations with non‐invasive light flicker has been reported to impact Alzheimer's disease‐related pathology. However, it is unclear which signaling pathways are involved in reducing amyloid load. Here, we found that gamma…
View article: Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model
Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model Open
Background Adult hippocampal neurogenesis (AHN) is restricted under the pathological conditions of neurodegenerative diseases, especially in Alzheimer’s disease (AD). The drop of AHN reduces neural circuit plasticity, resulting in the decr…
View article: Photobiomodulation therapy promotes the ATP‐binding cassette transporter A1‐dependent cholesterol efflux in macrophage to ameliorate atherosclerosis
Photobiomodulation therapy promotes the ATP‐binding cassette transporter A1‐dependent cholesterol efflux in macrophage to ameliorate atherosclerosis Open
Atherosclerosis is a chronic inflammatory disease related to a massive accumulation of cholesterol in the artery wall. Photobiomodulation therapy (PBMT) has been reported to possess cardioprotective effects but has no consensus on the unde…
View article: Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress‐Induced Depression
Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stress‐Induced Depression Open
Accumulating evidence indicates that dysfunction of the glutamatergic neurotransmission has been widely involved in the pathophysiology and treatment of depression. Photobiomodulation therapy (PBMT) has been demonstrated to regulate neuron…
View article: Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer's disease Open
Alzheimer's disease (AD), a severe age‐related neurodegenerative disorder, lacks effective therapeutic methods at present. Physical approaches such as gamma frequency light flicker that can effectively reduce amyloid load have been reporte…
View article: Cascade CRISPR/cas enables amplification-free microRNA sensing with fM-sensitivity and single-base-specificity
Cascade CRISPR/cas enables amplification-free microRNA sensing with fM-sensitivity and single-base-specificity Open
A cascade CRISPR/cas nucleic acid diagnostic system, which can achieve high-sensitive and single-base specificity without target amplification, was developed for miRNA detection.
View article: Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle
Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle Open
Supplementary material is available for this article at 10.1007/s12274-020-3028-x and is accessible for authorized users.
View article: CRISPR/Cas13a Powered Portable Electrochemiluminescence Chip for Ultrasensitive and Specific MiRNA Detection
CRISPR/Cas13a Powered Portable Electrochemiluminescence Chip for Ultrasensitive and Specific MiRNA Detection Open
MicroRNAs (miRNAs) have been widely investigated as potential biomarkers for early clinical diagnosis of cancer. Developing an miRNA detection platform with high specificity, sensitivity, and exploitability is always necessary. Electrochem…
View article: Real-Time Thermoacoustic Imaging-Guidance for Breast Tumor Resection
Real-Time Thermoacoustic Imaging-Guidance for Breast Tumor Resection Open
In situ image guidance is one of the key techniques for accurate diagnosis and treatment in clinical medicine. Conventional imaging techniques such as CT, MRI provide critical information for diagnosis and treatment planning, but are less …
View article: A bioorthogonal time-resolved luminogenic probe for metabolic labelling and imaging of glycans
A bioorthogonal time-resolved luminogenic probe for metabolic labelling and imaging of glycans Open
A terbium complex Tb-1 was demonstrated to undergo bioorthogonal ligation with engineered cell-surface glycans, which results in a much less efficient LRET and a 5-fold increase in long-lived terbium emission with low toxicity.
View article: Pancreatic Cancer detection via Galectin-1-targeted Thermoacoustic Imaging: validation in an <i>in vivo</i> heterozygosity model
Pancreatic Cancer detection via Galectin-1-targeted Thermoacoustic Imaging: validation in an <i>in vivo</i> heterozygosity model Open
Purpose: To investigate the feasibility of microwave-induced thermoacoustic imaging (MTAI) in detecting small pancreatic tumors (< 10 mm in diameter) and to complement the limitation of current clinical imaging methods. Methods: A home-mad…
View article: Targeting and Specific Activation of Antigen‐Presenting Cells by Endogenous Antigen‐Loaded Nanoparticles Elicits Tumor‐Specific Immunity
Targeting and Specific Activation of Antigen‐Presenting Cells by Endogenous Antigen‐Loaded Nanoparticles Elicits Tumor‐Specific Immunity Open
Immunotherapy has shown tremendous promise for improving cancer treatment. Unfortunately, antigen‐presenting cells (APCs) in cancer patients cannot effectively recognize and process tumor antigens to activate host immune responses. In this…
View article: Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer's disease models
Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer's disease models Open
A hallmark of Alzheimer's disease (AD) is the accumulation of amyloid‐β (Aβ), which correlates significantly with progressive cognitive deficits. Although photobiomodulation therapy (PBMT), as a novel noninvasive physiotherapy strategy, ha…
View article: Concurrent Drug Unplugging and Permeabilization of Polyprodrug‐Gated Crosslinked Vesicles for Cancer Combination Chemotherapy
Concurrent Drug Unplugging and Permeabilization of Polyprodrug‐Gated Crosslinked Vesicles for Cancer Combination Chemotherapy Open
Figure 3e in the published article contains inadvertent errors, and the wrong images for the H&E-staining were included in the prepared figures, which were then published in the article.The correct version of Figure 3e is shown here, with …
View article: Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood Brain Barrier Permeability Upregulating Nanoparticle
Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood Brain Barrier Permeability Upregulating Nanoparticle Open
In the originally published article, Figure S12 in the Supporting Information was presented incorrectly, wherein the Control and 0.5 mg/kg Den/RGD/CGS/Cy 5.5 panels in the third column (spleen), as well as 0.5 mg/kg Den/RGD/CGS/Cy 5.5 and …
View article: Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin‐Resistant <i>Staphylococcus aureus</i>
Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin‐Resistant <i>Staphylococcus aureus</i> Open
Small 2018, 14, 1802008 In the originally published article, Figure S3 and Figure S8 in the Supporting Information were presented incorrectly. The correct version is published online along with this Correction. None of the conclusions of t…
View article: Editorial
Editorial Open
Photoacoustic imaging and microwave-thermoacoustic imaging are innovative hybrid imaging techniques that have experienced rapid development in recent years.Photoacoustic imaging is based on the photoacoustic e®ect.When the laser pulses (th…
View article: Thermoacoustic Imaging and Therapy Guidance based on Ultra-short Pulsed Microwave Pumped Thermoelastic Effect Induced with Superparamagnetic Iron Oxide Nanoparticles
Thermoacoustic Imaging and Therapy Guidance based on Ultra-short Pulsed Microwave Pumped Thermoelastic Effect Induced with Superparamagnetic Iron Oxide Nanoparticles Open
Multifunctional nanoparticle-mediated imaging and therapeutic techniques are promising modalities for accurate localization and targeted treatment of cancer in clinical settings. Thermoacoustic (TA) imaging is highly sensitive to detect th…