Daan Beentjes
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View article: Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2
Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2 Open
Introduction Spores of the bacterium Bacillus subtilis ( B. subtilis ) have been shown to carry a number of properties potentially beneficial for vaccination. Firstly, as vehicles enabling mucosal delivery of heterologous antigens and seco…
View article: Inhaled Delivery of Killed Bacillus Subtilis Spores Protects Against Acute Viral Infections Caused by Influenza, RSV and SARS-CoV-2
Inhaled Delivery of Killed Bacillus Subtilis Spores Protects Against Acute Viral Infections Caused by Influenza, RSV and SARS-CoV-2 Open
View article: TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung
TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung Open
Streptococcus pneumoniae is a pathogen of global morbidity and mortality. Pneumococcal pneumonia can lead to systemic infections associated with high rates of mortality. We find that, upon pneumococcal infection, pulmonary Treg cells are a…
View article: Supplementary Material for: C-terminal PEGylation improves SAAP-148 peptide's immunomodulatory activities
Supplementary Material for: C-terminal PEGylation improves SAAP-148 peptide's immunomodulatory activities Open
Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant (AMR) bacteria withou…
View article: C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities
C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities Open
Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant bacteria without indu…
View article: Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission
Mechanistic Insights into the Impact of Air Pollution on Pneumococcal Pathogenesis and Transmission Open
Streptococcus pneumoniae (the pneumococcus) is the leading cause of pneumonia and bacterial meningitis. A number of recent studies indicate an association between the incidence of pneumococcal disease and exposure to air pollution. …
View article: Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models
Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models Open
Exposure to cigarette smoke (CS) is the primary risk factor for developing chronic obstructive pulmonary disease. The impact of CS exposure on the molecular mechanisms involved in mitochondrial quality control in airway epithelial cells is…