Daan Bunt
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View article: Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism
Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism Open
Mangiferin (MAN), a natural C-glycosylxanthone, is recognized for its health-promoting effects in traditional medicinal preparations. However, its poor bioavailability and limited intestinal permeability restrict its direct biological acti…
View article: The Synthesis of Aryl‐β‐<i>C</i>‐Glycosides from Native Saccharides
The Synthesis of Aryl‐β‐<i>C</i>‐Glycosides from Native Saccharides Open
The synthesis of p ‐nitrophenol‐β‐ C ‐glycosides from native mono‐, di‐, and trisaccharides is described. The one‐pot‐two‐step procedure uses water as the solvent and produces exclusively β‐ C ‐glycosides, the desired stereochemistry for m…
View article: High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i>
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i> Open
In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this pathogen to known drugs is increasing, and compounds with differen…
View article: Total synthesis of dissectol A, using an enediolate-based Tsuji–Trost reaction
Total synthesis of dissectol A, using an enediolate-based Tsuji–Trost reaction Open
The densely functionalized terpene glycoside dissectol A has been prepared via site-selective oxidation and an intramolecular Tsuji–Trost allylic alkylation reaction with an enediolate as the nucleophile.
View article: Practical Site-selective Oxidation of Glycosides with Pd(OAc)2/Neocuproine
Practical Site-selective Oxidation of Glycosides with Pd(OAc)2/Neocuproine Open
Palladium-catalyzed oxidation of the secondary C3 hydroxy group in glycopyranosides has set its mark in the selective modification of unprotected carbohydrates. The pre-formed catalyst [(neocuproine)PdOAc]2(OTf)2 oxidizes besides monosacch…
View article: Divergent Total Synthesis of Fornicin A, Fornicin D, and Ganodercin D, Meroterpenoids from <i>Ganoderma</i> Mushrooms
Divergent Total Synthesis of Fornicin A, Fornicin D, and Ganodercin D, Meroterpenoids from <i>Ganoderma</i> Mushrooms Open
The meroterpenoids fornicin A, fornicin D, and ganodercin D, found in mushrooms of the Ganoderma genus, have been prepared in a concise and divergent synthesis route. The characteristic unsaturated γ‐ketoacid moiety was obtained via an opt…
View article: Identification of three new inhibitor classes against Plasmodium falciparum
Identification of three new inhibitor classes against Plasmodium falciparum Open
In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this pathogen to known drugs is increasing and compounds with different…
View article: Potential Modulatory Microbiome Therapies for Prevention or Treatment of Inflammatory Bowel Diseases
Potential Modulatory Microbiome Therapies for Prevention or Treatment of Inflammatory Bowel Diseases Open
A disturbed interaction between the gut microbiota and the mucosal immune system plays a pivotal role in the development of inflammatory bowel disease (IBD). Various compounds that are produced by the gut microbiota, from its metabolism of…