Daan van Overveld
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View article: A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responses
A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responses Open
View article: Engineering a cleaved, prefusion-stabilized influenza B virus hemagglutinin by identification and locking of all six pH switches
Engineering a cleaved, prefusion-stabilized influenza B virus hemagglutinin by identification and locking of all six pH switches Open
Vaccine components based on viral fusion proteins require high stability of the native prefusion conformation for optimal potency and manufacturability. In the case of influenza B virus hemagglutinin (HA), the stem's conformation relies on…
View article: Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer
Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer Open
View article: Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies
Structural basis for potent neutralization of human respirovirus type 3 by protective single-domain camelid antibodies Open
View article: Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein
Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein Open
View article: Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G
Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G Open
Human respiratory syncytial virus (RSV) poses a significant human health threat, particularly to infants and the elderly. While efficacious vaccines based on the F protein have recently received market authorization, uncertainties remain r…