Dacheng Ding
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View article: High-Flow Intracranial-Intracranial Interposition Bypass from A1 to M2 with Proximal Occlusion for a Large Unruptured Fusiform Aneurysm of the Middle Cerebral Artery M1 Segment: A Technical Note
High-Flow Intracranial-Intracranial Interposition Bypass from A1 to M2 with Proximal Occlusion for a Large Unruptured Fusiform Aneurysm of the Middle Cerebral Artery M1 Segment: A Technical Note Open
High-flow IC-IC bypass from A1 to M2 with proximal occlusion is a safe and effective strategy for selected complex fusiform M1 aneurysms, preserving distal and perforator flow while reducing aneurysm inflow when conventional options are li…
View article: Arsenic Trioxide Induces Retinoic Acid-Related Orphan Receptor Beta and Blocks the WNT Pathway to Inhibit Stemness in Glioblastoma
Arsenic Trioxide Induces Retinoic Acid-Related Orphan Receptor Beta and Blocks the WNT Pathway to Inhibit Stemness in Glioblastoma Open
Glioblastoma (GBM) is a malignant primary brain tumor and an essential contributor to morbidity and mortality globally. Arsenic trioxide (ATO) exerts specific roles in preventing tumor growth. This study investigated the role of ATO in GBM…
View article: The prognostic significance and immune correlation of SLC10A3 in low-grade gliomas revealed by bioinformatic analysis and multiple immunohistochemistry
The prognostic significance and immune correlation of SLC10A3 in low-grade gliomas revealed by bioinformatic analysis and multiple immunohistochemistry Open
Up-regulation of SLC10A3 mRNA is statistically associated with adverse survival outcomes and immune infiltration among LGGs. SLC10A3 might be a reliable survival predictor and a promising immunotherapy target for LGG patients.
View article: Impact of Low‐Volume, Low‐Pressure Tracheostomy Cuffs on Acute Mucosal Injury in Swine
Impact of Low‐Volume, Low‐Pressure Tracheostomy Cuffs on Acute Mucosal Injury in Swine Open
Objective Tapered low‐volume, low‐pressure (LVLP) cuffs have been introduced to improve sealing and reduce injury from tracheostomy and endotracheal intubation compared to traditional cylindrical high‐volume, low‐pressure (HVLP) cuffs. The…
View article: Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis
Glutamine Inhibition Reduces Iatrogenic Laryngotracheal Stenosis Open
Objective/Hypothesis Glutamine inhibition has been demonstrated an antifibrotic effect in iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts in vitro. We hypothesize that broadly active glutamine antagonist, DON will reduce collag…
View article: Quantitative Assessment of the Immune Microenvironment in Patients With Iatrogenic Laryngotracheal Stenosis
Quantitative Assessment of the Immune Microenvironment in Patients With Iatrogenic Laryngotracheal Stenosis Open
Objective Iatrogenic laryngotracheal stenosis (iLTS) is characterized by fibroinflammatory narrowing of the upper airway and is most commonly caused by intubation injury. Evidence suggests a key role for CD4 T cells in its pathogenesis. Th…
View article: Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type <scp>II</scp> Diabetes Mellitus
Characterization of Fibroblasts in Iatrogenic Laryngotracheal Stenosis and Type <span>II</span> Diabetes Mellitus Open
Objectives Iatrogenic laryngotracheal stenosis (iLTS) is the pathological narrowing of the glottis, subglottis, and/or trachea due to scar tissue. Patients with type 2 diabetes mellitus (T2DM) are over 8 times more likely to develop iLTS a…
View article: <scp>M2</scp> Macrophages Promote Collagen Expression and Synthesis in Laryngotracheal Stenosis Fibroblasts
<span>M2</span> Macrophages Promote Collagen Expression and Synthesis in Laryngotracheal Stenosis Fibroblasts Open
Objective Macrophages exhibit distinct phenotypes and are dysregulated in a model of iatrogenic laryngotracheal stenosis (iLTS). Increased populations of alternatively activated or M2 macrophages have been demonstrated. However, the role o…
View article: Increased Expression of <scp>PD</scp>‐1 and <scp>PD‐L1</scp> in Patients With Laryngotracheal Stenosis
Increased Expression of <span>PD</span>‐1 and <span>PD‐L1</span> in Patients With Laryngotracheal Stenosis Open
Objectives Laryngotracheal stenosis (LTS) is a fibrotic condition of the upper airway. Recent evidence suggests dysregulated host immunity plays a role in LTS development and progression. The programmed death‐1 (PD‐1)/programmed death‐liga…
View article: Laryngotracheal Mucosal Surface Expression of Candidate Biomarkers in Idiopathic Subglottic Stenosis
Laryngotracheal Mucosal Surface Expression of Candidate Biomarkers in Idiopathic Subglottic Stenosis Open
Objectives Idiopathic subglottic stenosis (iSGS) is an inflammatory process leading to fibrosis and narrowing of the laryngotracheal airway. There is variability in patient response to surgical intervention, but the mechanisms underlying t…
View article: Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis Open
Laryngotracheal stenosis (LTS) is a pathologic narrowing of the subglottis and trachea leading to extrathoracic obstruction and significant shortness of breath. LTS results from mucosal injury from a foreign body in the trachea, leading to…
View article: Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis
Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis Open
Objectives/Hypothesis Glutamine metabolism is a critical energy source for iatrogenic laryngotracheal stenosis (iLTS) scar fibroblasts, and glutaminase (GLS) is an essential enzyme converting glutamine to glutamate. We hypothesize that the…
View article: Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis
Engineering an immunomodulatory drug-eluting stent to treat laryngotracheal stenosis Open
A rapamycin-eluting PLLA-PCL stent is deployed into a diseased mouse trachea to treat laryngotracheal stenosis.
View article: DIPG-34. A HUMAN NEURAL STEM CELL DIPG MODEL IDENTIFIES THE RELATIVE CONTRIBUTION OF DIFFERENT ONCOGENIC ELEMENTS TO INVASIVE MALIGNANT TRANSFORMATION
DIPG-34. A HUMAN NEURAL STEM CELL DIPG MODEL IDENTIFIES THE RELATIVE CONTRIBUTION OF DIFFERENT ONCOGENIC ELEMENTS TO INVASIVE MALIGNANT TRANSFORMATION Open
Nearly 80% of Diffuse Intrinsic Pontine Glioma (DIPG) harbor H3K27M mutation which is inversely correlated with reduced survival, and 60% of H3K27M mutant cells are associated with TP53 mutation. However, it is unclear how those mutations …
View article: Targeting metabolic abnormalities to reverse fibrosis in iatrogenic laryngotracheal stenosis
Targeting metabolic abnormalities to reverse fibrosis in iatrogenic laryngotracheal stenosis Open
Objective Management of laryngotracheal stenosis (LTS) remains primarily surgical, with a critical need to identify targets for adjuvant therapy. Laryngotracheal stenosis scar fibroblasts exhibit a profibrotic phenotype with distinct metab…
View article: Interferon-γ Treatment of Human Laryngotracheal Stenosis–Derived Fibroblasts
Interferon-γ Treatment of Human Laryngotracheal Stenosis–Derived Fibroblasts Open
Interferon-γ reduced proliferation, soluble collagen production, and collagen expression in LTS-derived fibroblasts while also reducing the expression of the profibrotic cytokine transforming growth factor β. These findings suggest that th…
View article: Quantification of Inflammatory Markers in Laryngotracheal Stenosis
Quantification of Inflammatory Markers in Laryngotracheal Stenosis Open
Objectives (1) Develop a novel method for serial assessment of gene and protein expression in laryngotracheal stenosis (LTS). (2) Assess cytokine expression and determine an immunophenotype in LTS. Study Design A matched comparison of endo…
View article: Fibroblasts in Hypoxic Conditions Mimic Laryngotracheal Stenosis
Fibroblasts in Hypoxic Conditions Mimic Laryngotracheal Stenosis Open
Objective To elucidate the role of hypoxia and inflammatory pathways in the pathogenesis of iatrogenic laryngotracheal stenosis (iLTS). Study Design (1) Examination of mucosal surface gene expression in human iLTS. (2) In vitro comparison …
View article: Metabolic variations in normal and fibrotic human laryngotracheal‐derived fibroblasts: A Warburg‐like effect
Metabolic variations in normal and fibrotic human laryngotracheal‐derived fibroblasts: A Warburg‐like effect Open
Objectives/Hypothesis Laryngotracheal stenosis (LTS) is a chronic fibrotic disease characterized by fibroblast proliferation, collagen deposition, and matrix remodeling in the lamina propria of the larynx and/or trachea. Current medical th…
View article: <i>Tle4</i> null mice have significant aberrations in hematopoietic stem and progenitor cells (HSPC).
<i>Tle4</i> null mice have significant aberrations in hematopoietic stem and progenitor cells (HSPC). Open
Bar graphs with representative flow cytometry plots in two week old littermates (a) show significant loss of LSK and LKS CD34+ cells, though the most immature long-term HSC population (LKS CD34+CD48–CD150+ HSC) is relatively preserved. (b)…
View article: Dysregulated Macrophages Are Present in Bleomycin‐Induced Murine Laryngotracheal Stenosis
Dysregulated Macrophages Are Present in Bleomycin‐Induced Murine Laryngotracheal Stenosis Open
Objective To define the inflammatory cell infiltrate preceding fibrosis in a laryngotracheal stenosis (LTS) murine model. Study Design Prospective controlled murine study. Setting Laboratory. Subjects and Methods Chemomechanical injury mic…
View article: Rapamycin Inhibits Human Laryngotracheal Stenosis–derived Fibroblast Proliferation, Metabolism, and Function in Vitro
Rapamycin Inhibits Human Laryngotracheal Stenosis–derived Fibroblast Proliferation, Metabolism, and Function in Vitro Open
Objective To determine if rapamycin inhibits the growth, function, and metabolism of human laryngotracheal stenosis (LTS)–derived fibroblasts. Study Design Controlled in vitro study. Setting Tertiary care hospital in a research university.…