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View article: ENHANCED COMBINED EFFECTS OF GARCINIA COWA BARK EXTRACT AND DOXORUBICIN ON CELL CYCLE REGULATION AND P53 EXPRESSION IN T47D BREAST CANCER CELLS
ENHANCED COMBINED EFFECTS OF GARCINIA COWA BARK EXTRACT AND DOXORUBICIN ON CELL CYCLE REGULATION AND P53 EXPRESSION IN T47D BREAST CANCER CELLS Open
Objective: To evaluate the effects of ethanol extract of Garcinia cowa bark (EEGCB) and doxorubicin (Dox), both individually and in combination, on cell cycle regulation and protein expression in T47D breast cancer cells. Methods: T47D cel…
View article: Apoptosis and cell cycle regulatory of voacangine ısolated from Voacanga foetida (Blume) Rolfe on MCF7 breast cancer cells: In silico and in vitro studies
Apoptosis and cell cycle regulatory of voacangine ısolated from Voacanga foetida (Blume) Rolfe on MCF7 breast cancer cells: In silico and in vitro studies Open
Voacangine is a mono-indole alkaloid reported to have cytotoxic activity against several cancer cells. This study aimed to explore the ability of voacangine to induce apoptosis and cell cycle arrest on MCF7 through in silico and in vitro s…
View article: EXPLORING ANTI-TYROSINASE AND PHOTOPROTECTIVE ACTIVITIES OF Curcuma heyneana (Val.) AND Kaempferia galanga (L.) ESSENTIAL OILS: IN VITRO AND IN SILICO APPROACHES
EXPLORING ANTI-TYROSINASE AND PHOTOPROTECTIVE ACTIVITIES OF Curcuma heyneana (Val.) AND Kaempferia galanga (L.) ESSENTIAL OILS: IN VITRO AND IN SILICO APPROACHES Open
The essential oils of Curcuma heyneana and Kaempferia galanga are known for their antioxidant, anti-inflammatory, and antibacterial biological activities. However, studies of their anti-tyrosinase activity and photoprotective effects are s…
View article: Uncaria nervosa Elmer, a new herbal source for betulinic acid and ursolic acid: Metabolites profiling, isolation, and in vitro cytotoxicity studies against T47D breast cancer
Uncaria nervosa Elmer, a new herbal source for betulinic acid and ursolic acid: Metabolites profiling, isolation, and in vitro cytotoxicity studies against T47D breast cancer Open
Background Uncaria nervosa Elmer is an Indonesian herbal plant that is traditionally used for breast cancer. The results of phytochemical screening contained alkaloids, flavonoids, and terpenoids in the ethanol extract of this plant. Based…
View article: Immunostimulant Studies of NK Cells, CD8+ T Cells and Perforin From Ethanol Extract of Elephantopus scaber Linn. Leaf
Immunostimulant Studies of NK Cells, CD8+ T Cells and Perforin From Ethanol Extract of Elephantopus scaber Linn. Leaf Open
Elephantopus scaber Linn , traditionally, boosts the immune system, highlighting its potential for scientific investigation. This study aims to determine the effect of E. scaber leaf extract on NK cells, CD8+ T cells and perforin in male w…
View article: Dual-Method Apoptosis Evaluation Reveals the Therapeutic Potential of Garcinia cowa Extract in Combination with Doxorubicin for Breast Cancer Treatment
Dual-Method Apoptosis Evaluation Reveals the Therapeutic Potential of Garcinia cowa Extract in Combination with Doxorubicin for Breast Cancer Treatment Open
Breast cancer remains a major health challenge worldwide, demanding the exploration of novel therapeutic agents with improved efficacy and safety. Garcinia cowa, a traditional medicinal plant, has shown promising cytotoxic activity in prev…
View article: Volatilomics and Physical Characteristics of Chicken and Pork “Urutan” (Traditional Balinese Sausage)
Volatilomics and Physical Characteristics of Chicken and Pork “Urutan” (Traditional Balinese Sausage) Open
— “Urutan” is a traditional Balinese fermented sausage prepared from pork or chicken. Information on chemical and physical characteristics of “Urutan” is important, specifically for Muslims unable to consume pork. Therefore, this study aim…
View article: Physicochemical characteristics and SPME-GC-MS based volatilomics for discrimination of beef and pork patties
Physicochemical characteristics and SPME-GC-MS based volatilomics for discrimination of beef and pork patties Open
Beef is the preferred main ingredient for patties due to its high nutritional value; however, it is also a costly commodity. As a result, beef is often adulterated or partially substituted with pork, which can raise ethical and religious c…
View article: Analysis of Nutritional Problems using Focused Interviews Method in Elementary School Children (Later Childhood) in Batam City
Analysis of Nutritional Problems using Focused Interviews Method in Elementary School Children (Later Childhood) in Batam City Open
Optimal nutrition significantly impacts human health, particularly for primary school-aged children. Malnutrition manifests in various health issues, such as stunting, underweight, micronutrient deficiencies, and obesity. The prevalence of…
View article: EXPLORING THE THERAPEUTIC POTENTIAL: METABOLITE PROFILING, ANTIBACTERIAL ACTION, AND ANTIAGING PROPERTIES OF ESSENTIAL OILS FROM CURCUMA MANGGA, BOESENBERGIA ROTUNDA, AND ZINGIBER PURPUREUM RHIZOMES
EXPLORING THE THERAPEUTIC POTENTIAL: METABOLITE PROFILING, ANTIBACTERIAL ACTION, AND ANTIAGING PROPERTIES OF ESSENTIAL OILS FROM CURCUMA MANGGA, BOESENBERGIA ROTUNDA, AND ZINGIBER PURPUREUM RHIZOMES Open
Objective: Bacterial infections and aging are common skin issues, with antibiotics and chemical treatments often causing side effects. Essential oils from Zingiberaceae rhizomes could offer safer antibacterial and anti-aging alternatives. …
View article: Evaluating socio-demographic, behavioral, and maternal factors in the dual burden of malnutrition among school-aged children in Batam, Indonesia
Evaluating socio-demographic, behavioral, and maternal factors in the dual burden of malnutrition among school-aged children in Batam, Indonesia Open
Malnutrition among school-aged children in urban-industrial settings presents a dual burden of undernutrition and overnutrition. The aim of this study was to examine factors influencing the nutritional status of elementary school children …
View article: Immunoactivities of fractions of Elephantopus scaber linn leaf in NK cells, CD8+ T cells, and perforin
Immunoactivities of fractions of Elephantopus scaber linn leaf in NK cells, CD8+ T cells, and perforin Open
The goal of this study is to determine the effect of a fraction of Elephantopus scaber Linn leaf extract on NK cells, CD8+ T cells, and perforin in male white mice using one dose of Elephantopus scaber Linn fraction at 30 mg/kg BW. In this…
View article: Synergistic Anti-Migration Effects of Garcinia cowa and Doxorubicin in T47D Breast Cancer Cells: A Scratch Assay Analysis
Synergistic Anti-Migration Effects of Garcinia cowa and Doxorubicin in T47D Breast Cancer Cells: A Scratch Assay Analysis Open
Objective: Breast cancer metastasis is a major cause of mortality, highlighting the need for effective anti-migratory therapies. This study investigated the synergistic anti-migratory effects of Garcinia cowa bark ethanol extract and doxor…
View article: Chemometrics applications in omics studies (Metabolomics, Lipidomics, and Proteomics) for halal authentication in food and pharmaceutical products
Chemometrics applications in omics studies (Metabolomics, Lipidomics, and Proteomics) for halal authentication in food and pharmaceutical products Open
As awareness of using halal products increases, the halal status of food and pharmaceutical products is receiving heightened attention. Omic-based analytical methods such as Metabolomics, Lipidomics, and Proteomics have been tested to auth…
View article: Recent progress on the application of molecular spectroscopic and chromatographic methods for analysis of Halal and Kosher gelatins in food and pharmaceutical products
Recent progress on the application of molecular spectroscopic and chromatographic methods for analysis of Halal and Kosher gelatins in food and pharmaceutical products Open
Gelatin can be obtained by hydrolysis of collagen partially from the skin, bone, and connective tissues of animals in acid or basic conditions, and is a functional ingredient widely used in some products which are related to food, cosmetic…
View article: Metabolite profiling, antioxidant, and in vitro wound healing activities of Citrus medica L. and Citrus x microcarpa Bunge peels and leaves essential oils
Metabolite profiling, antioxidant, and in vitro wound healing activities of Citrus medica L. and Citrus x microcarpa Bunge peels and leaves essential oils Open
Wound care is still dominated by the use of synthetic chemicals such as anti-inflammatory drugs, corticosteroids and antibiotics which have many shortcomings. One potential alternative to be developed is essential oils. Citrus are members …
View article: Characterization and anti-aging activities of Haruan (Channa striata) fish oil
Characterization and anti-aging activities of Haruan (Channa striata) fish oil Open
Haruan fish or snakehead fish (Channa striata) is a freshwater fish widely cultivated in Indonesia. Fish oils are believed to have some biological activities which are beneficial to human health, including antioxidant and antiaging activit…
View article: Chemometrics Assisted-Liquid Chromatography (LC)-Orbitrap High Resolution Mass Spectrometry (HRMS) Non-Targeted Metabolomics for Identification of Dog Meat in Beef Sausages
Chemometrics Assisted-Liquid Chromatography (LC)-Orbitrap High Resolution Mass Spectrometry (HRMS) Non-Targeted Metabolomics for Identification of Dog Meat in Beef Sausages Open
View article: Uncaria nervosa Elmer, a new herbal source for betulinic acid and ursolic acid: Metabolites profiling, isolation, and in vitro cytotoxicity studies against T47D breast cancer
Uncaria nervosa Elmer, a new herbal source for betulinic acid and ursolic acid: Metabolites profiling, isolation, and in vitro cytotoxicity studies against T47D breast cancer Open
* Background Uncaria nervosa Elmer is an Indonesian herbal plant that is traditionally used for breast cancer. The results of phytochemical screening contained alkaloids, flavonoids, and terpenoids in the ethanol extract of this plant. Bas…
View article: The use of real-time polymerase chain reaction for detection of raw rat meat(Rattus norvegicus) with species-specific primer for halal authentication
The use of real-time polymerase chain reaction for detection of raw rat meat(Rattus norvegicus) with species-specific primer for halal authentication Open
Rat meat (RM) can be obtained freely from farmers and can be used as a potential adulterant in meat-based food products. The presence of RM in any food products is prohibited by the Muslim community and is considered non-halal meat. Theref…
View article: FT-IR Fingerprinting Analysis for Classification of West Sumatra Small Ginger (Zingiber officinale Roscoe) Essential Oil and Its Antioxidant Activity
FT-IR Fingerprinting Analysis for Classification of West Sumatra Small Ginger (Zingiber officinale Roscoe) Essential Oil and Its Antioxidant Activity Open
Due to its essential oil content, the community utilises the small ginger rhizome as traditional medicine and spices. This study aims to compare the antioxidant activity of small ginger essential oil (SGEO) from six different altitudes in …
View article: GC-MS and ATR-FTIR Spectroscopy Coupled with Chemometric Analysis for Detection and Quantification of White Turmeric (Curcuma zedoaria) Essential Oils Adulteration
GC-MS and ATR-FTIR Spectroscopy Coupled with Chemometric Analysis for Detection and Quantification of White Turmeric (Curcuma zedoaria) Essential Oils Adulteration Open
Background and Objective: White turmeric essential oil (WTEO) is known to have high commercial value since it has been used to improve immunological function, increase blood circulation, ease toxin clearance and stimulate digestion.…
View article: EFFECT OF COWANIN ON CYCLIN D1 EXPRESSION IN MCF-7/HER2 BREAST CANCER CELLS
EFFECT OF COWANIN ON CYCLIN D1 EXPRESSION IN MCF-7/HER2 BREAST CANCER CELLS Open
Objective: Cowanin, isolated from the stem bark of Asam kandis (Garcinia cowa Roxb.) has been known to have cytotoxic activity in MCF-7/HER2 breast cancer cells. Recent studies have reported that cowanin compounds can inhibit MCF-7/HER2 ce…
View article: UNRAVELLING THE INTERACTION BETWEEN GARCINISIDONE-A AND HER2 PROTEIN IN BREAST CANCER: A COMPUTATIONAL STUDY
UNRAVELLING THE INTERACTION BETWEEN GARCINISIDONE-A AND HER2 PROTEIN IN BREAST CANCER: A COMPUTATIONAL STUDY Open
Objective: One substance found in the leaves of Garcinia cowa Roxb that has anticancer properties is garcinisidone-A. The study aims to simulate the docking of garcinisidone-A (Gar-A), molecular dynamics, and predict the ADME by predicting…
View article: RAPID DETECTION OF RAT MEAT ADULTERATION IN BEEF SAUSAGES USING FTIR‑ATR SPECTROSCOPY AND CHEMOMETRICS FOR HALAL AUTHENTICATION
RAPID DETECTION OF RAT MEAT ADULTERATION IN BEEF SAUSAGES USING FTIR‑ATR SPECTROSCOPY AND CHEMOMETRICS FOR HALAL AUTHENTICATION Open
Objective: The objective of this study was to employ Fourier Transform Infrared-Attenuated Total Reflectance (FTIR‑ATR) spectroscopy in combination with chemometrics for the analysis of rat meat adulteration in beef sausages. Methods: Lipi…
View article: ANALYSIS OF TURMERIC (CURCUMA LONGA LINN) ESSENTIAL OIL FROM DIFFERENT GROWING LOCATIONS USING FTIR/GC-MS SPECTROSCOPY COUPLED TO CHEMOMETRICS AND ITS WOUND HEALING ACTIVITIES
ANALYSIS OF TURMERIC (CURCUMA LONGA LINN) ESSENTIAL OIL FROM DIFFERENT GROWING LOCATIONS USING FTIR/GC-MS SPECTROSCOPY COUPLED TO CHEMOMETRICS AND ITS WOUND HEALING ACTIVITIES Open
Objective: This study aims to determine the wound-healing activity of turmeric essential oil (TEO) collected from seven growing locations in West Sumatra, classify it based on fingerprint patterns of IR spectra combined with chemometrics, …
View article: CYTOTOXIC ACTIVITY OF TAXUS SUMATRANA (MIQ.) DE LAUB. BARK, LEAVES, AND SHOOTS ON HELA, T47D, AND MCF-7/HER2 CELL LINES
CYTOTOXIC ACTIVITY OF TAXUS SUMATRANA (MIQ.) DE LAUB. BARK, LEAVES, AND SHOOTS ON HELA, T47D, AND MCF-7/HER2 CELL LINES Open
Objective: Taxus sumatrana (Miq.) de Laub. (cemara Sumatra) is one of the plants found in Indonesia and other countries known as a medicine plant. Taxus's bark, leaves, and shoots are used traditionally and massively for some diseases (can…
View article: STUDY OF ACTIVE ISOLATED COMPOUNDS FROM SUNGKAI LEAF (PERONEMA CANESCENS JACK) AS IMMUNOSTIMULANT FROM EXPOSURE OF THE SARS-COV-2 VIRUS ANTIGEN TO NATURAL KILLER CELLS
STUDY OF ACTIVE ISOLATED COMPOUNDS FROM SUNGKAI LEAF (PERONEMA CANESCENS JACK) AS IMMUNOSTIMULANT FROM EXPOSURE OF THE SARS-COV-2 VIRUS ANTIGEN TO NATURAL KILLER CELLS Open
Objective: SARS-CoV-2 is an illness that attacks the respiratory tract's alveoli lining cells. One approach to tackling it is to strengthen the immune system of the body, which has an organ specifically dedicated to defending against disea…
View article: CURCUMA AERUGINOSA ROXB. EXTRACT INHIBITS THE PRODUCTION OF PROINFLAMMATORY CYTOKINES ON RAW 264.7 MACROPHAGES
CURCUMA AERUGINOSA ROXB. EXTRACT INHIBITS THE PRODUCTION OF PROINFLAMMATORY CYTOKINES ON RAW 264.7 MACROPHAGES Open
Objective: The study explores the potential of Curcuma aeruginosa Roxb. extract for anti-inflammatory properties. Methods: Curcuma aeruginosa Roxb. simplicia was macerated with distilled ethanol. In vitro testing was done on Raw 264.7 macr…
View article: Development of FTIR Spectroscopy and multivariate calibration forauthentication beef meatballs from pork meat
Development of FTIR Spectroscopy and multivariate calibration forauthentication beef meatballs from pork meat Open
In several countries, especially Indonesia, meatballs are one of the favorite foods made from meat. The high price of beef is a reason for adulterated beef meat with pork to gain a significant profit. All food products must not contain pig…