Daeahn Cho
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View article: Challenging AlphaFold in predicting proteins with large-scale allosteric transitions
Challenging AlphaFold in predicting proteins with large-scale allosteric transitions Open
Many proteins function by toggling between distinct conformations, yet most structure predictors have been trained on data that do not capture this conformational diversity. Here, we benchmarked AlphaFold2, AlphaFold3, and recent variants …
View article: A computational clinical decision-supporting system to suggest effective anti-epileptic drugs for pediatric epilepsy patients based on deep learning models using patient’s medical history
A computational clinical decision-supporting system to suggest effective anti-epileptic drugs for pediatric epilepsy patients based on deep learning models using patient’s medical history Open
Background Epilepsy, a chronic brain disorder characterized by abnormal brain activity that causes seizures and other symptoms, is typically treated using anti-epileptic drugs (AEDs) as the first-line therapy. However, due to the variation…
View article: A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration
A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration Open
The accumulation of misfolded and aggregated proteins is a hallmark of neurodegenerative proteinopathies. Although multiple genetic loci have been associated with specific neurodegenerative diseases (NDs), molecular mechanisms that may hav…