Daehan Lee
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View article: A GPCR signaling pathway in insect odor detection
A GPCR signaling pathway in insect odor detection Open
Odor detection differs fundamentally in vertebrates, which use G protein-coupled receptors (GPCRs) 1,2 , and insects, which employ ion channels 3,4 . Here, we report the first evidence for a GPCR defining tuning properties of insect olfact…
View article: Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation
Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation Open
To explore how brains change upon species evolution, we generated single-cell transcriptomic atlases of the central brains of three closely related but ecologically distinct drosophilids: the generalists Drosophila melanogaster and Drosoph…
View article: Multilayer regulation underlies the functional precision and evolvability of the olfactory system
Multilayer regulation underlies the functional precision and evolvability of the olfactory system Open
Sensory neurons must be reproducibly specified to permit accurate neural representation of external signals but also able to change during evolution. We studied this paradox in the Drosophila olfactory system by establishing a single-cell …
View article: HLH-30/TFEB mediates sexual dimorphism in immunity in <i>Caenorhabditis elegans</i>
HLH-30/TFEB mediates sexual dimorphism in immunity in <i>Caenorhabditis elegans</i> Open
Sexual dimorphism affects various biological functions, including immune responses. However, the mechanisms by which sex alters immunity remain largely unknown. Using Caenorhabditis elegans as a model species, we showed that males exhibit …
View article: Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior
Glial expression of a steroidogenic enzyme underlies natural variation in hitchhiking behavior Open
Phoresy is an interspecies interaction that facilitates spatial dispersal by attaching to a more mobile species. Hitchhiking species have evolved specific traits for physical contact and successful phoresy, but the regulatory mechanisms in…
View article: Comparative single-cell transcriptomic atlases reveal conserved and divergent features of drosophilid central brains
Comparative single-cell transcriptomic atlases reveal conserved and divergent features of drosophilid central brains Open
To explore how brains change upon species evolution, we generated single-cell transcriptomic atlases of the central brains of three closely-related but ecologically-distinct drosophilids: the generalists Drosophila melanogaster and Drosoph…
View article: Natural genetic variation in the pheromone production of <i>C. elegans</i>
Natural genetic variation in the pheromone production of <i>C. elegans</i> Open
From bacterial quorum sensing to human language, communication is essential for social interactions. Nematodes produce and sense pheromones to communicate among individuals and respond to environmental changes. These signals are encoded by…
View article: <i>daf-42</i>is an evolutionarily young gene essential for dauer development in<i>Caenorhabditis elegans</i>
<i>daf-42</i>is an evolutionarily young gene essential for dauer development in<i>Caenorhabditis elegans</i> Open
Under adverse environmental conditions, nematodes arrest into dauer, an alternative developmental stage for diapause. Dauer endures unfavorable environments and interacts with host animals to access favorable environments, thus playing a c…
View article: Natural genetic variation in the pheromone production of<i>C. elegans</i>
Natural genetic variation in the pheromone production of<i>C. elegans</i> Open
From bacterial quorum sensing to human language, communication is essential for social interactions. Nematodes produce and sense pheromones to communicate among individuals and respond to environmental changes. These signals are encoded by…
View article: Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of <i>Caenorhabditis elegans</i> across the Hawaiian Islands
Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of <i>Caenorhabditis elegans</i> across the Hawaiian Islands Open
The nematode Caenorhabditis elegans is among the most widely studied organisms, but relatively little is known about its natural ecology. Genetic diversity is low across much of the globe but high in the Hawaiian Islands and across the Pac…
View article: An atlas of gene expression variation across the <i>Caenorhabditis elegans</i> species
An atlas of gene expression variation across the <i>Caenorhabditis elegans</i> species Open
Phenotypic variation in diverse organism-level traits have been studied in Caenorhabditis elegans wild strains, but differences in gene expression and the underlying variation in regulatory mechanisms are largely unknown. Here, we use natu…
View article: Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of <i>Caenorhabditis elegans</i> across the Hawaiian Islands
Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of <i>Caenorhabditis elegans</i> across the Hawaiian Islands Open
The nematode Caenorhabditis elegans is among the most widely studied organisms, but relatively little is known about its natural ecology. Wild C. elegans have been isolated from both temperate and tropical climates, where they feed on bact…
View article: An Experimental Analysis of Active Pitch Control for an Assault Amphibious Vehicle Considering Waterjet-Hydrofoil Interaction Effect
An Experimental Analysis of Active Pitch Control for an Assault Amphibious Vehicle Considering Waterjet-Hydrofoil Interaction Effect Open
The present study aims to reduce the pitch motion of an assault amphibious vehicle system in seaways by waterjet impeller revolution rate control. A series of seakeeping tests were performed in a towing tank with a 1/4.5-scale model. This …
View article: Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila
Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila Open
The Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understanding mechanisms underlying hematopoiesis and immunity. Three types of mature hemocytes have b…
View article: Balancing selection maintains hyper-divergent haplotypes in<i>C. elegans</i>
Balancing selection maintains hyper-divergent haplotypes in<i>C. elegans</i> Open
Across diverse taxa, selfing species have evolved independently from outcrossing species thousands of times. The transition from outcrossing to selfing significantly decreases the effective population size, effective recombination rate, an…
View article: A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans
A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans Open
Over long evolutionary timescales, major changes to the copy number, function, and genomic organization of genes occur, however, our understanding of the individual mutational events responsible for these changes is lacking. In this report…
View article: Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations
Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations Open
Hawaiian isolates of the nematode species Caenorhabditis elegans have long been known to harbor genetic diversity greater than the rest of the worldwide population, but this observation was supported by only a small number of wild strains.…
View article: Deep sampling of Hawaiian<i>Caenorhabditis elegans</i>reveals high genetic diversity and admixture with global populations
Deep sampling of Hawaiian<i>Caenorhabditis elegans</i>reveals high genetic diversity and admixture with global populations Open
Recent efforts to understand the natural niche of the keystone model organism Caenorhabditis elegans have suggested that this species is cosmopolitan and associated with rotting vegetation and fruits. However, most of the strains isolated …
View article: A Novel Gene Underlies Bleomycin-Response Variation in<i>Caenorhabditis elegans</i>
A Novel Gene Underlies Bleomycin-Response Variation in<i>Caenorhabditis elegans</i> Open
Bleomycin is a powerful chemotherapeutic drug used to treat a variety of cancers. However, individual patients vary in their responses to bleomycin. The identification of genetic differences that underlie this response variation could impr…
View article: Selection and gene flow shape niche-associated copy-number variation of pheromone receptor genes
Selection and gene flow shape niche-associated copy-number variation of pheromone receptor genes Open
From quorum sensing in bacteria to pheromone signaling in social insects, chemical communication mediates interactions among individuals in a local population. In Caenorhabditis elegans , ascaroside pheromones can dictate local population …
View article: A beneficial genomic rearrangement creates multiple versions of calcipressin in<i>C. elegans</i>
A beneficial genomic rearrangement creates multiple versions of calcipressin in<i>C. elegans</i> Open
Gene duplication is a major source of genetic novelty and evolutionary adaptation, providing a molecular substrate that can generate biological complexity and diversity (Ohno 1967, Taylor and Raes 2004). Despite an abundance of genomic evi…
View article: A nematode-specific gene underlies bleomycin-response variation in<i>Caenorhabditis elegans</i>
A nematode-specific gene underlies bleomycin-response variation in<i>Caenorhabditis elegans</i> Open
Bleomycin is a powerful chemotherapeutic drug used to treat a variety of cancers. However, individual patients vary in their responses to bleomycin. The identification of genetic differences that underlie this response variation could impr…
View article: Development of a new tool for objective risk assessment and comparative analysis at coastal waters
Development of a new tool for objective risk assessment and comparative analysis at coastal waters Open
The International Association of Marine Aids to Navigation and Lighthouse Authorities (IALA) introduced maritime traffic risk assessment models such as Waterway Risk Assessment Program and Ports and Waterway Safety Assessment for being use…
View article: Discovery of genomic intervals that underlie nematode responses to benzimidazoles
Discovery of genomic intervals that underlie nematode responses to benzimidazoles Open
Parasitic nematodes impose a debilitating health and economic burden across much of the world. Nematode resistance to anthelmintic drugs threatens parasite control efforts in both human and veterinary medicine. Despite this threat, the gen…
View article: The Local Coexistence Pattern of Selfing Genotypes in <i>Caenorhabditis elegans</i> Natural Metapopulations
The Local Coexistence Pattern of Selfing Genotypes in <i>Caenorhabditis elegans</i> Natural Metapopulations Open
To study the interplay of rare outcrossing and metapopulation structure, we focus on the nematode Caenorhabditis elegans. Its remarkably low outcrossing rate is at the extreme end of the spectrum for facultative selfing organisms. At the d…
View article: The genetic basis of natural variation in a phoretic behavior
The genetic basis of natural variation in a phoretic behavior Open
Phoresy is a widespread form of commensalism that facilitates dispersal of one species through an association with a more mobile second species. Dauer larvae of the nematode Caenorhabditis elegans exhibit a phoretic behavior called nictati…