Daekyu Sun
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View article: Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids
Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids Open
Dietary flavonoids are a group of polyphenol compounds originating from plants that have drawn much attention in the last few decades. Flavonoid-rich foods and dietary supplements are used worldwide due to their health benefits, including …
View article: Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes
Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes Open
Aberrant gene expression is often linked to the progression of various cancers, making the targeting of oncogene transcriptional activation a potential strategy to control tumor growth and development. The RET proto-oncogene’s gain-of-func…
View article: Synthesis of Alamandine Glycoside Analogues as New Drug Candidates to Antagonize the MrgD Receptor for Pain Relief
Synthesis of Alamandine Glycoside Analogues as New Drug Candidates to Antagonize the MrgD Receptor for Pain Relief Open
Two series of putatively brain-penetrant alamandine glycosides have been prepared for screening against the MrgD receptor. One series has retained the first 6 residues of the alamandine sequence (ARVYIH), replacing the terminal proline (P)…
View article: Selective Antitumor Activity of Datelliptium toward Medullary Thyroid Carcinoma by Downregulating RET Transcriptional Activity
Selective Antitumor Activity of Datelliptium toward Medullary Thyroid Carcinoma by Downregulating RET Transcriptional Activity Open
Medullary thyroid carcinoma (MTC) is a rare aggressive form of thyroid cancer with high rates of metastasis. Sporadic and hereditary MTC are strongly driven by somatic and germline mutations, respectively, in the transmembrane REarranged d…
View article: Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma
Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma Open
Rearranged during transfection kinase (RET) is a validated molecular target in medullary thyroid cancer (MTC), as activating mutations in RET are often associated with the development of MTC. The present study reports the first preclinical…
View article: Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes
Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quadruplexes and G-Quadruplex-Protein Complexes Open
View article: Synthesis of Constrained Heterocycles Employing Two Post‐Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity
Synthesis of Constrained Heterocycles Employing Two Post‐Ugi Cyclization Methods for Rapid Library Generation with In Cellulo Activity Open
Benzimidazoles and quinoxalinones are present in the core of many pharmacologically relevant compounds. Several combinatorial methods have been developed to attach ring systems to both scaffolds for derivatization at select positions. Here…
View article: Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative
Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative Open
Dominant-activating mutations in the RET (rearranged during transfection) proto-oncogene, which encodes a receptor tyrosine kinase, is often associated with the development of medullary thyroid carcinoma (MTC). The proximal promoter region…
View article: Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine
Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine Open