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View article: Prevalence of Alzheimer’s disease pathology in the community
Prevalence of Alzheimer’s disease pathology in the community Open
The prevalence of Alzheimer’s disease neuropathological changes (ADNCs), the leading cause of cognitive impairment, remains uncertain. Recent blood-based biomarkers enable scalable assessment of ADNCs 1 . Here we measured phosphorylated ta…
View article: Informed Choices and Early Dementia Risk Disclosure in Home‐Based Assessments in the PREDICTOM Study: A Public Involvement Approach
Informed Choices and Early Dementia Risk Disclosure in Home‐Based Assessments in the PREDICTOM Study: A Public Involvement Approach Open
Background The rapid progress in detecting dementia risk through emerging digital biomarkers and biofluid markers, alongside the development of disease modifying treatments (DMTs), underscores the importance of this evolving field. The PRE…
View article: Mega‐Analysis of Oscillatory and Aperiodic Resting‐State EEG Alterations in Neurodegenerative Diseases
Mega‐Analysis of Oscillatory and Aperiodic Resting‐State EEG Alterations in Neurodegenerative Diseases Open
Background Resting‐state EEG (rsEEG) alterations in the posterior alpha rhythm are promising biomarkers of neurodegenerative diseases (NDDs). However, spectral analysis often overlooks the rsEEG non‐rhythmic (aperiodic) component. Studies …
View article: Nocturnal Sleep Measured by Actigraphy and Questionnaires in Care Home Residents Living with Late‐Stage Dementia and Agitation
Nocturnal Sleep Measured by Actigraphy and Questionnaires in Care Home Residents Living with Late‐Stage Dementia and Agitation Open
Background Sleep disturbances are common in dementia patients, and nocturnal behavioural and psychological symptoms of dementia (BPSD) are particularly challenging to caregivers. Measuring them currently relies on carer‐rated questionnaire…
View article: Motivational strategies to improve adherence to dementia preventive lifestyle changes
Motivational strategies to improve adherence to dementia preventive lifestyle changes Open
Background Dementia represents a significant global health challenge, necessitating innovative prevention strategies. Lifestyles aimed at reducing dementia risk typically combine physical and cognitive training, nutritional adaptations, an…
View article: Sleep‐Related Disturbances, Psychosis, and Cognitive Decline in Healthy Older Adults: A Cross Sectional Analysis of PROTECT Study Data
Sleep‐Related Disturbances, Psychosis, and Cognitive Decline in Healthy Older Adults: A Cross Sectional Analysis of PROTECT Study Data Open
Background Sleep‐related disturbances are commonly reported in approximately 50% of older adults and have been associated with various psychiatric (e.g., psychosis) and neurodegenerative disorders (e.g., dementia). While the overlapping re…
View article: Discerning cognitive domains through online assessment in aging participants in Norwegian Cohort 50+
Discerning cognitive domains through online assessment in aging participants in Norwegian Cohort 50+ Open
Cognitive decline is a significant aspect of aging, varying across domains such as executive function, working memory, and attention. Identifying modifiable risk factors and their domain-specific effects is crucial to mitigating age-relate…
View article: Does Platelet Transcriptome Dysregulation Across the Lewy Body Continuum Mirror Neuronal Dysfunction?
Does Platelet Transcriptome Dysregulation Across the Lewy Body Continuum Mirror Neuronal Dysfunction? Open
Platelets are increasingly recognized as multifunctional cells with roles extending beyond hemostasis to immune regulation, inflammation, and neurodegeneration. Here, we performed RNA-Seq profiling of platelets from patients with idiopathi…
View article: Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study
Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study Open
Objectives Neurogranin (Ng) has a role in synaptic plasticity and is considered a biomarker of synaptic dysfunction, a process hypothesised to be important in delirium. Few studies examining Ng in delirium exist, with mixed findings. This …
View article: Gut enterotype- and body mass index (BMI)-dependent effects of anthocyanin supplementation on gut microbiota composition in individuals at risk for cognitive decline: a randomized placebo-controlled trial
Gut enterotype- and body mass index (BMI)-dependent effects of anthocyanin supplementation on gut microbiota composition in individuals at risk for cognitive decline: a randomized placebo-controlled trial Open
Anthocyanins, bioactive flavonoids found in berries, modulate gut microbiota composition and influence health outcomes. This study investigated the effects of anthocyanin supplementation on gut microbiota and cognition in older adults (60-…
View article: The computerised PROTECT Cognitive Test System is sensitive to dementia and correlates with Alzheimer-related blood biomarkers
The computerised PROTECT Cognitive Test System is sensitive to dementia and correlates with Alzheimer-related blood biomarkers Open
Early detection of cognitive impairment is essential for timely diagnosis and to support recruitment of pre-clinical patients into trials of disease-modifying therapies. Current clinically used tools have limited sensitivity for early cogn…
View article: Differential diagnosis of dementias using in vivo MRI and data-driven disease progression modelling: a case study in Alzheimer’s disease and dementia with Lewy bodies
Differential diagnosis of dementias using in vivo MRI and data-driven disease progression modelling: a case study in Alzheimer’s disease and dementia with Lewy bodies Open
Alzheimer’s disease (AD) and Dementia with Lewy bodies (DLB) are neurodegenerative diseases often sharing clinical symptoms, causing frequent misdiagnoses. Using data from multiple cohorts we improve and apply the SuStaIn algorithm on regi…
View article: Aesthetic Experience in the Acceptance of Wearable Technology for People With Dementia: Critical Interpretive Synthesis
Aesthetic Experience in the Acceptance of Wearable Technology for People With Dementia: Critical Interpretive Synthesis Open
Background The prevalence of dementia has led to a growing interest in wearable technologies to assist dementia care. Despite their potential, these technologies face low adoption rates, often attributed to poor aesthetic design and insuff…
View article: Characterizing resting-state EEG oscillatory and aperiodic activity in neurodegenerative diseases: A multicentric study
Characterizing resting-state EEG oscillatory and aperiodic activity in neurodegenerative diseases: A multicentric study Open
Batch effects in the rsEEG power spectrum can be mitigated with harmonization. Oscillatory alpha power reduction may better reflect AD abnormalities, whereas pronounced oscillatory frequency slowing and greater aperiodic activity character…
View article: Low Frequency of Dementia with Lewy Bodies Diagnosis in a Colombian Memory Clinic
Low Frequency of Dementia with Lewy Bodies Diagnosis in a Colombian Memory Clinic Open
Background The global burden of dementia is increasing, particularly in low‐ and middle‐income countries. Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia but remains underreported and frequently misdiag…
View article: Co‐pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms
Co‐pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms Open
BACKGROUND Mixed neuropathology is common in dementia, but the clinical implications for neuropsychiatric symptoms (NPSs) are not well characterized. METHODS In a population‐based post mortem study, cases with Alzheimer's disease neuropath…
View article: Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum
Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum Open
Cerebrovascular disease is common in patients on the Lewy body (LB) continuum (dementia with Lewy bodies (DLB) and prodromal-DLB). White matter signal abnormality (WMSA) volume is higher in patients with LB than controls, both globally and…
View article: Effects of Oral Anthocyanin Supplementation on In Vitro Neurogenesis, Hippocampus-Dependent Cognition, and Blood-Based Dementia Biomarkers: Results from a 24-Week Randomized Controlled Trial in Older Adults At Risk for Dementia (ACID)
Effects of Oral Anthocyanin Supplementation on In Vitro Neurogenesis, Hippocampus-Dependent Cognition, and Blood-Based Dementia Biomarkers: Results from a 24-Week Randomized Controlled Trial in Older Adults At Risk for Dementia (ACID) Open
Background: Identifying compounds with neuroprotective properties that target the neurogenic process will have a considerable impact on dementia prevention. Methods: This is a secondary analysis of a 24-week randomised, double-blind, place…
View article: Delirium prevalence and incidence in acutely admitted older patients: an observational cohort study
Delirium prevalence and incidence in acutely admitted older patients: an observational cohort study Open
Background Delirium is common in acutely ill older adults and is associated with multiple unfavourable outcomes, including an increased risk of dementia and death. As the population ages and more people live with dementia, updated and accu…
View article: Defining health and lifestyle characteristics of the age 50+ population: cluster analysis of data from the PROTECT study
Defining health and lifestyle characteristics of the age 50+ population: cluster analysis of data from the PROTECT study Open
Introduction The proportion of older people in the world is increasing and evidence suggests that older adults interact differently with products. Understanding this change is necessary to develop products that satisfy this cohort’s needs.…
View article: Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes
Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes Open
Clinically, Alzheimer's disease (AD) is characterized by progressive cognitive decline due to neuronal and synaptic degeneration. Neurofilament light chain (NfL) and total tau (T-tau) reflect neurodegeneration, NfL putatively more related …
View article: Body Mass Index and Age-Adjusted Body Mass Index in Older Individuals: Clinical and Functional Correlations across Categories. Study from 30 904 Older Adults Living in the Community
Body Mass Index and Age-Adjusted Body Mass Index in Older Individuals: Clinical and Functional Correlations across Categories. Study from 30 904 Older Adults Living in the Community Open
Body Mass Index (BMI) use in older adults has been questioned as it does not account for the loss of height with age, overestimating weight status. We explored age-height loss adjusted BMI (BMI-A) correlation with health variables, the sig…
View article: Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies
Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies Open
Dementia with Lewy bodies (DLB), a progressive neurodegenerative disease with heterogeneous clinical presentations, greatly impacts patients, caregivers, and society. Despite its frequency, diagnosing and treating DLB remains challenging. …
View article: A common outcome set for trials in dementia with Lewy bodies (DLB COS)
A common outcome set for trials in dementia with Lewy bodies (DLB COS) Open
INTRODUCTION Methodological heterogeneity in dementia with Lewy bodies (DLB) trials contributes to publication bias and makes evidence synthesis and meta‐analysis challenging. We aimed to develop a core outcome set for DLB (DLB COS) trials…
View article: Recruitment for dementia clinical trials in care homes: an evaluation of strategies employed in the Sativex® for the treatment of Agitation in Dementia (‘STAND’) Trial
Recruitment for dementia clinical trials in care homes: an evaluation of strategies employed in the Sativex® for the treatment of Agitation in Dementia (‘STAND’) Trial Open
Clinical trials in dementia face significant recruitment challenges, with only 1% of eligible participants typically engaged in research. The ‘Sativex for the Treatment of AgitatioN in Dementia’ (STAND) trial implemented innovative recruit…