Dagmar Gotthardt
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View article: Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching
Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching Open
Lymphocyte migration plays a crucial role in the progression of autoimmune and inflammatory diseases, and the inhibition of autoreactive immune cells is an attractive therapeutic strategy. Pepitem is an endogenous modulator of lymphocyte m…
View article: Supplementary Figure 1 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 1 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S1: Flow cytometric analysis and gating strategies.
View article: Supplementary Figure 11 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 11 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S11: The expression of LY6E on K562 does not impact on IFN-γ or TNF-α production in NK cells.
View article: Supplementary Figure 7 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 7 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S7: Analysis of differentially accessible genes in NK cell resistant tumour cells.
View article: Supplementary Figure 8 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 8 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S8: Secondary resistant B-ALL cell clones.
View article: Supplementary Figure 5 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 5 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S5: Extended quantification of NK cell-mediated cancer immunoediting in vitro.
View article: Supplementary Table 1 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Table 1 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Table 1: Primers. Columns show primer name, sequence, usage, annealing temperature (in °C), and used polymerase.
View article: Supplementary Figure 3 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 3 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S3: Flow cytometric analyses of human data sets and the NK-cell receptor ligand analyses on mouse B-ALL cell lines.
View article: Supplementary Figure 4 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 4 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S4: B-ALL cell line characterisation and details about the barcode library.
View article: Supplementary Figure 9 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 9 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S9: Profiles of tumour cells co-cultured with WT, Prf1-/- or Ifng-/- NK cells.
View article: Data from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Data from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
The term cancer immunoediting describes the dual role by which the immune system can suppress and promote tumor growth and is divided into three phases: elimination, equilibrium, and escape. The role of NK cells has mainly been attributed …
View article: Supplementary Figure 6 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 6 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S6: Analysis of differentially expressed genes in NK cell resistant tumour cells.
View article: Supplementary Figure 2 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 2 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S2: Flow cytometric analysis and gating strategies shown in Figure 5.
View article: Supplementary Table 2 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Table 2 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Table 2: Antibodies and viability dyes used for flow cytometric analyses and immunoblotting. Indicated are target antigens, conjugates, clones, suppliers, catalogue numbers, and used working dilutions.
View article: Supplementary Figure 10 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Supplementary Figure 10 from Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
Supplementary Figure S10: Generation of Plaat3 KO B-ALL clones and their characterisation.
View article: Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia
Natural Killer Cell–Mediated Cytotoxicity Shapes the Clonal Evolution of B-cell Leukemia Open
The term cancer immunoediting describes the dual role by which the immune system can suppress and promote tumor growth and is divided into three phases: elimination, equilibrium, and escape. The role of NK cells has mainly been attributed …
View article: Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions
Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions Open
Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin 12 family responses. Here we…
View article: Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas
Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas Open
A hallmark feature of pancreatic ductal adenocarcinoma (PDAC) is massive intratumoral fibrosis, designated as desmoplasia. Desmoplasia is characterized by the expansion of cancer-associated fibroblasts (CAFs) and a massive increase in extr…
View article: Cyclin C promotes development and progression of B-cell acute lymphoblastic leukemia by counteracting p53-mediated stress responses
Cyclin C promotes development and progression of B-cell acute lymphoblastic leukemia by counteracting p53-mediated stress responses Open
Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cance…
View article: Boosting the anti-tumor activity of natural killer cells by caripe 8 – A Carapichea ipecacuanha isolated cyclotide
Boosting the anti-tumor activity of natural killer cells by caripe 8 – A Carapichea ipecacuanha isolated cyclotide Open
Cyclotides are head-to-tail cyclized peptides with a unique cystine-knot motif. Their structure provides exceptional resistance against enzymatic, chemical, or thermal degradation compared to other peptides. Peptide-based therapeutics prom…
View article: The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis Open
Innate lymphoid cells (ILCs) are critical for intestinal adaptation to microenvironmental challenges, and the gut mucosa is characterized by low oxygen. Adaptation to low oxygen is mediated by hypoxia-inducible transcription factors (HIFs)…
View article: A lineage-specific <i>STAT5B</i> N642H mouse model to study NK-cell leukemia
A lineage-specific <i>STAT5B</i> N642H mouse model to study NK-cell leukemia Open
Patients with T- and natural killer (NK)-cell neoplasms frequently have somatic STAT5B gain-of-function mutations. The most frequent STAT5B mutation is STAT5BN642H, which is known to drive murine T-cell leukemia, although its role in NK-ce…
View article: Natural killer cell cytotoxicity shapes the clonal evolution of B cell leukaemia
Natural killer cell cytotoxicity shapes the clonal evolution of B cell leukaemia Open
The term cancer immunoediting describes the dual role by which the immune system can suppress and promote tumour growth and is divided into three phases: elimination, equilibrium and escape. The role of NK cells has mainly been attributed …
View article: AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity
AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity Open
The proper functioning of cytotoxic lymphocytes, such as natural killer and CD8+ T cells, is essential for effective cancer-immunity and immunotherapy responses. The differentiation of these cells is controlled by several transcription fac…
View article: A lineage-specific<i>STAT5B</i><sup>N642H</sup>mouse model to study NK-cell leukemia
A lineage-specific<i>STAT5B</i><sup>N642H</sup>mouse model to study NK-cell leukemia Open
Patients with T- and NK-cell neoplasms frequently have somatic STAT5B gain-of-function mutations. The most frequent STAT5B mutation is STAT5B N642H , which is known to drive murine T-cell leukemia although its role in NK-cell malignancies …
View article: Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice
Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice Open
FAM3C/ILEI is an important factor in epithelial-to-mesenchymal transition (EMT) induction, tumor progression and metastasis. Overexpressed in many cancers, elevated ILEI levels and secretion correlate with poor patient survival. Although I…
View article: Targeting iron import to treat ANKL
Targeting iron import to treat ANKL Open
In this issue of Blood, Shao et al 1 reveal that ZDHHC21-mediated palmitoylation regulates oxidative phosphorylation and is essential for a subset of acute myeloid leukemia (AML) cells.
View article: The CD16 and CD32b Fc-gamma receptors regulate antibody-mediated responses in mouse natural killer cells
The CD16 and CD32b Fc-gamma receptors regulate antibody-mediated responses in mouse natural killer cells Open
Natural killer (NK) cells are innate lymphocytes capable of mediating immune responses without prior sensitization. NK cells express Fc-gamma receptors (FcγR) that engage the Fc region of IgG. Studies investigating the role of FcγR on mous…