Dagmar Heuer
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View article: Autochthonous transmission of extensively drug-resistant Neisseria gonorrhoeae in Germany, 2025
Autochthonous transmission of extensively drug-resistant Neisseria gonorrhoeae in Germany, 2025 Open
We report four confirmed autochthonously transmitted gonorrhoea cases in Germany in 2025, with Neisseria gonorrhoeae isolates exhibiting high-level azithromycin and cefixime resistance. Regarding ceftriaxone, isolates were susceptible for …
View article: Recruitment of the cellular lipid transport protein CERT to C. psittaci inclusions regulates the timing of bacterial egress
Recruitment of the cellular lipid transport protein CERT to C. psittaci inclusions regulates the timing of bacterial egress Open
View article: Inc/GFP chimera protein-based interactomics reveals host cellular interactions of Cps0558, a novel <i>Chlamydia psittaci</i> inclusion protein
Inc/GFP chimera protein-based interactomics reveals host cellular interactions of Cps0558, a novel <i>Chlamydia psittaci</i> inclusion protein Open
The obligate intracellular Gram-negative bacterium Chlamydia psittaci, a zoonotic pathogen transmissible between birds and humans, has played a pioneering role in research on its membrane-bound replicative niche termed the inclusion. Inclu…
View article: Recruitment of the cellular lipid transport protein CERT to<i>C. psittaci</i>inclusions regulates the timing of bacterial egress
Recruitment of the cellular lipid transport protein CERT to<i>C. psittaci</i>inclusions regulates the timing of bacterial egress Open
Egress of intracellular pathogens is highly regulated and carefully timed. For the zoonotic bacterium C. psittaci , the predominant egress pathway is Chlamydia -containing sphere (CCS) formation, a calcium-dependent sequential mechanism in…
View article: Entschlüsselung eines neuen Austrittswegs von Chlamydien
Entschlüsselung eines neuen Austrittswegs von Chlamydien Open
Chlamydia spp. are pathogenic bacteria sharing an obligate intracellular cycle of development including host cell invasion, intracellular replication and egress. In the past, egress of Chlamydia spp. was described to be either lytic or non…
View article: <i>Chlamydia</i> -containing spheres are a novel and predominant form of egress by the pathogen <i>Chlamydia psittaci</i>
<i>Chlamydia</i> -containing spheres are a novel and predominant form of egress by the pathogen <i>Chlamydia psittaci</i> Open
The egress of intracellular bacteria from host cells and cellular tissues is a critical process during the infection cycle. This process is essential for bacteria to spread inside the host and can influence the outcome of an infection. For…
View article: Antimicrobial-resistant Neisseria gonorrhoeae in Europe in 2020 compared with in 2013 and 2018: a retrospective genomic surveillance study
Antimicrobial-resistant Neisseria gonorrhoeae in Europe in 2020 compared with in 2013 and 2018: a retrospective genomic surveillance study Open
European Centre for Disease Prevention and Control and Örebro University Hospital.
View article: High tetracycline resistance percentages in Neisseria gonorrhoeae in Europe: is doxycycline post-exposure prophylaxis unlikely to reduce the incident gonorrhoea cases?
High tetracycline resistance percentages in Neisseria gonorrhoeae in Europe: is doxycycline post-exposure prophylaxis unlikely to reduce the incident gonorrhoea cases? Open
View article: Integrated molecular, phenotypic and epidemiological surveillance of antimicrobial resistance in Neisseria gonorrhoeae in Germany
Integrated molecular, phenotypic and epidemiological surveillance of antimicrobial resistance in Neisseria gonorrhoeae in Germany Open
Numbers of infections with Neisseria gonorrhoeae are among the top three sexually transmitted infections (STI) worldwide. In addition, the emergence and spread of antimicrobial resistance (AMR) in Neisseria gonorrhoeae pose an important pu…
View article: Developing a next level integrated genomic surveillance: Advances in the molecular epidemiology of HIV in Germany
Developing a next level integrated genomic surveillance: Advances in the molecular epidemiology of HIV in Germany Open
Advances in the molecular epidemiological studies of the Human Immunodeficiency Virus (HIV) at the Robert Koch Institute (RKI) by laboratory and bioinformatic automation should allow the processing of larger numbers of samples and more com…
View article: The formation of<i>Chlamydia</i>-containing spheres, a novel non-lytic egress pathway of the zoonotic pathogen<i>Chlamydia psittaci</i>
The formation of<i>Chlamydia</i>-containing spheres, a novel non-lytic egress pathway of the zoonotic pathogen<i>Chlamydia psittaci</i> Open
Egress of intracellular bacteria from host cells and cellular tissues is a critical process during the infection cycle. This egress process is essential for bacteria to spread inside the host and can influence the outcome of an infection. …
View article: Markedly decreasing azithromycin susceptibility of Neisseria gonorrhoeae, Germany, 2014 to 2021
Markedly decreasing azithromycin susceptibility of Neisseria gonorrhoeae, Germany, 2014 to 2021 Open
We monitored antimicrobial susceptibility developments of Neisseria gonorrhoeae in Germany from January 2014 to May 2021. The proportion of isolates with azithromycin minimum inhibitory concentrations above the epidemiological cut-off incr…
View article: P232 Antimicrobial Resistance of Neisseria gonorrhoeae in Germany 2016–2020, results from the Gonococcal Resistance Network (GORENET)
P232 Antimicrobial Resistance of Neisseria gonorrhoeae in Germany 2016–2020, results from the Gonococcal Resistance Network (GORENET) Open
Background In Germany, Neisseria gonorrhoeae (NG) infections are not reportable and limited data on epidemiology and antimicrobial resistance (AMR) are available. Within the Gonococcal Resistance Network (GORENET) we monitor the NG-AMR in …
View article: P172 The mosaic mtr locus as major genetic determinant of azithromycin resistance of Neisseria gonorrhoeae, Germany, 2018
P172 The mosaic mtr locus as major genetic determinant of azithromycin resistance of Neisseria gonorrhoeae, Germany, 2018 Open
Background Azithromycin resistant Neisseria gonorrhoeae (NG) isolates increased from 4.3% in 2016 to 9.2% in 2018 within the German Gonococcal Resistance Network (GORENET) NG sample collection. Using whole genome sequencing (WGS) of NG iso…
View article: Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017
Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017 Open
Background Emerging antimicrobial resistance (AMR) challenges gonorrhoea treatment and requires surveillance. Aim This observational study describes the genetic diversity of Neisseria gonorrhoeae isolates in Germany from 2014 to 2017 and i…
View article: Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)
Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT) Open
Ceramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step of sphingomyelin biosynthesis. Usually, CERT ligands are evaluated in tedi…
View article: External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany
External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany Open
View article: Einführung einer Meldepflicht für von N. gonorrhoeae mit verminderter Empfindlichkeit gegenüber Azithromycin, Cefixim oder Ceftriaxon
Einführung einer Meldepflicht für von N. gonorrhoeae mit verminderter Empfindlichkeit gegenüber Azithromycin, Cefixim oder Ceftriaxon Open
Mit Wirkung zum 1. März 2020 wird eine nicht-namentliche, laborbasierte Meldepflicht gemäß § 7 Abs. 3 IfSG auf den Nachweis von Infektionen mit N. gonorrhoeae mit verminderter Empfindlichkeit gegenüber Azithromycin, Cefixim oder Ceftriaxon…
View article: Additional file 1 of External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany
Additional file 1 of External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany Open
Additional file 1: Table S1. Consensus values for susceptibility testing. Values for minimal inhibitory concentrations (MIC) and susceptibility categories (R: resistant, I: intermediate, S: sensitive) and outcome of Beta-Lactamase testing …
View article: Additional file 2 of External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany
Additional file 2 of External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany Open
Additional file 2: Table S2. Absolute average deviation from consensus minimal inhibitory concentration (MIC) for each antibiotic agent tested and laboratory. Steps represent the scale on MIC gradient strips (two steps = one doubling dilut…
View article: Sphingolipid Metabolism and Transport in Chlamydia trachomatis and Chlamydia psittaci Infections
Sphingolipid Metabolism and Transport in Chlamydia trachomatis and Chlamydia psittaci Infections Open
Chlamydia species infect a large range of vertebral hosts and have become of major economic and public health concern over the last decades. They are obligate intracellular bacteria that undergo a unique cycle of development charact…
View article: Gonorrhö mit einem high-level-Azithromycin-resistenten Erreger in Deutschland
Gonorrhö mit einem high-level-Azithromycin-resistenten Erreger in Deutschland Open
Das Epidemiologische Bulletin 32/33 2019 berichtet über eine urogenitale Gonorrhö bei einem 42-jährigen Patienten mit einem high-level-Azithromycin-resistenten N. gonorrhoeae-Stamm. Die Erkrankung wurde Ende Juni 2019 in Deutschland diagno…
View article: Dataset for External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany
Dataset for External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany Open
This dataset is used for the publication "External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany" and contains data on performed Neisseria gonorrhoeae AMR tests in…
View article: Dataset for External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany
Dataset for External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany Open
This dataset is used for the publication "External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany" and contains data on performed Neisseria gonorrhoeae AMR tests in…
View article: P671 Distribution of antimicrobial resistance in<i>neisseria gonorrhoeae</i>– 5 years of german gonococcal resistance network (GORENET)
P671 Distribution of antimicrobial resistance in<i>neisseria gonorrhoeae</i>– 5 years of german gonococcal resistance network (GORENET) Open
Background The widespread antimicrobial resistance (AMR) of Neisseria gonorrhoeae (NG) is a serious problem for the treatment of gonorrhoea. Because NG infections are not reportable in Germany, only limited data on disease epidemiol…
View article: P636 High diversity of<i>neisseria gonorrhoeae</i>in germany revealed by molecular typing using NG-MAST (2014–17)
P636 High diversity of<i>neisseria gonorrhoeae</i>in germany revealed by molecular typing using NG-MAST (2014–17) Open
Background Neisseria gonorrhoeae (NG) infections are not reportable in Germany. The Gonococcal Resistance Network (GORENET) is a laboratory network to monitor antimicrobial resistance (AMR) in Germany, linking data from sequence typ…
View article: P658 Did minimum inhibitory concentrations in<i>N. gonorrhoeae</i>isolates change in germany since 2014?
P658 Did minimum inhibitory concentrations in<i>N. gonorrhoeae</i>isolates change in germany since 2014? Open
Background German national guidelines recommend ceftriaxone combined with azithromycin for Neisseria gonorrhoeae (NG) treatment since 2014. The Gonococcal-Resistance-Network (GORENET) monitors gonococcal antimicrobial resistance (AM…
View article: Drei Fälle von Gonorrhö mit ausgeprägter Antibiotika-Resistenz und Therapieversagen in Australien und Großbritannien
Drei Fälle von Gonorrhö mit ausgeprägter Antibiotika-Resistenz und Therapieversagen in Australien und Großbritannien Open
View article: The cellular ceramide transport protein CERT promotes<i>Chlamydia psittaci</i>infection and controls bacterial sphingolipid uptake
The cellular ceramide transport protein CERT promotes<i>Chlamydia psittaci</i>infection and controls bacterial sphingolipid uptake Open
Chlamydiaceae are bacterial pathogens that cause diverse diseases in humans and animals. Despite their broad host and tissue tropism, all Chlamydia species share an obligate intracellular cycle of development and have evolved sophisticated…
View article: The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components
The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components Open
Chlamydia trachomatis is an important human pathogen that replicates inside the infected host cell in a unique vacuole, the inclusion. The formation of this intracellular bacterial niche is essential for productive Chlamydia infections. De…