Dagmar Klein
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View article: Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage Open
Human pancreatic plasticity is implied from multiple single-cell RNA sequencing (scRNA-seq) studies. However, these have been invariably based on static datasets from which fate trajectories can only be inferred using pseudotemporal estima…
View article: Population Pharmacokinetics and Pharmacodynamics of Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction
Population Pharmacokinetics and Pharmacodynamics of Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction Open
NCT01951625.
View article: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
Long-term culture of human pancreatic slices as a model to study real-time islet regeneration Open
The culture of live pancreatic tissue slices is a powerful tool for the interrogation of physiology and pathology in an in vitro setting that retains near-intact cytoarchitecture. However, current culture conditions for human pancreatic sl…
View article: Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche
Single-cell resolution analysis of the human pancreatic ductal progenitor cell niche Open
We have described multipotent progenitor-like cells within the major pancreatic ducts (MPDs) of the human pancreas. They express PDX1, its surrogate surface marker P2RY1, and the bone morphogenetic protein (BMP) receptor 1A (BMPR1A)/activi…
View article: The Role of MicroRNAs in Diabetes-Related Oxidative Stress
The Role of MicroRNAs in Diabetes-Related Oxidative Stress Open
Cellular stress, combined with dysfunctional, inadequate mitochondrial phosphorylation, produces an excessive amount of reactive oxygen species (ROS) and an increased level of ROS in cells, which leads to oxidation and subsequent cellular …
View article: BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion
BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion Open
The exocrine pancreas can give rise to endocrine insulin-producing cells upon ectopic expression of key transcription factors. However, the need for genetic manipulation remains a translational hurdle for diabetes therapy. Here we report t…