Dagui Lin
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View article: Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis
Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis Open
View article: Identification of Key Genes in Colorectal Cancer Associated with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease
Identification of Key Genes in Colorectal Cancer Associated with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease Open
Inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) are both gastrointestinal inflammatory diseases that exhibit a significant correlation with an elevated incidence of colorectal cancer (CRC). However, the mechanisms…
View article: FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity
FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity Open
Nasopharyngeal carcinoma (NPC)-mediated immunosuppression within the tumor microenvironment (TME) frequently culminates in the failure of otherwise promising immunotherapies. In this study, we identify tumor-intrinsic FLI1 as a critical me…
View article: Circulating tumor DNA analysis predicts recurrence and avoids unnecessary adjuvant chemotherapy in I–IV colorectal cancer
Circulating tumor DNA analysis predicts recurrence and avoids unnecessary adjuvant chemotherapy in I–IV colorectal cancer Open
Background: Circulating tumor DNA (ctDNA) has emerged as a biomarker that can define the risk of recurrence after curative-intent surgery for patients with colorectal cancer (CRC). However, beyond the predictive power of postoperative ctDN…
View article: Identification and validation of a novel stress granules-related prognostic model in colorectal cancer
Identification and validation of a novel stress granules-related prognostic model in colorectal cancer Open
Aims: A growing body of evidence demonstrates that Stress granules (SGs), a non-membrane cytoplasmic compartments, are important to colorectal development and chemoresistance. However, the clinical and pathological significance of SGs in c…
View article: Clinical Evidence of Chemotherapy or Endocrine Therapy Maintenance in Patients with Metastatic Breast Cancer: Meta-Analysis of Randomized Clinical Trials and Propensity Score Matching of Multicenter Cohort Study
Clinical Evidence of Chemotherapy or Endocrine Therapy Maintenance in Patients with Metastatic Breast Cancer: Meta-Analysis of Randomized Clinical Trials and Propensity Score Matching of Multicenter Cohort Study Open
Purpose This study aims to comprehensively evaluate the clinical efficacy of chemotherapy or endocrine therapy maintenance in metastatic breast cancer (MBC) patients.Materials and Methods The meta-analysis of randomized clinical trials (RC…
View article: Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC
Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC Open
View article: Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer
Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer Open
View article: Additional file 1 of Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC
Additional file 1 of Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC Open
Additional file 1: Supplementary Figure S1. Correlation between SPON2 expression and immune cell signatures in TCGA COAD and READ data. a. The heat map of the expression of immune cells between high- and low-expressed SPON2. b. The Pearson…
View article: Additional file 4 of Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer
Additional file 4 of Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer Open
Additional file 4: Table S4. Twenty-eight immune cells and corresponding gene signatures.
View article: Additional file 5 of Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer
Additional file 5 of Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer Open
Additional file 5: Table S5. Immune-related pathways and corresponding gene signatures.
View article: Additional file 6 of Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer
Additional file 6 of Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer Open
Additional file 6: Table S6. Survival-related metabolic genes used for unsupervised clustering in the GSE39582 dataset.
View article: Prognostic and immunological role of CD36: A pan-cancer analysis
Prognostic and immunological role of CD36: A pan-cancer analysis Open
CD36 plays a critical role in lipid metabolism, which is closely associated with human immunity. However, the role of CD36 in cancer remains unclear. We performed a pan-cancer analysis to elucidate the potential role of CD36 in cancer by i…
View article: Clinical Evidence of Chemotherapy or Endocrine Therapy Maintenance in Patients With Metastatic Breast Cancer After First-Line Chemotherapy
Clinical Evidence of Chemotherapy or Endocrine Therapy Maintenance in Patients With Metastatic Breast Cancer After First-Line Chemotherapy Open
View article: Association of immune checkpoint inhibitor with survival in patients with cancers with protein tyrosine phosphatase receptor T mutation
Association of immune checkpoint inhibitor with survival in patients with cancers with protein tyrosine phosphatase receptor T mutation Open
Dear Editor, We and others have shown that the tumor mutation burden (TMB) and several underlying oncogenic alterations could provide clinically predictive implications for immune checkpoint inhibitor (ICI).1-3 Protein tyrosine phosphatase…
View article: Clinical evidence for association of neoadjuvant chemotherapy or chemoradiotherapy with efficacy and safety in patients with resectable esophageal carcinoma (NewEC study)
Clinical evidence for association of neoadjuvant chemotherapy or chemoradiotherapy with efficacy and safety in patients with resectable esophageal carcinoma (NewEC study) Open
View article: Association of Immune Checkpoint Inhibitor Therapy With Survival in Patients With Cancers With <i>MUC16</i> Variants
Association of Immune Checkpoint Inhibitor Therapy With Survival in Patients With Cancers With <i>MUC16</i> Variants Open
This cohort study investigates whether MUC16 variation could be a useful biomarker for immune checkpoint inhibitor (ICI) therapy.
View article: Novel blood‐based tumor mutation algorithm and nomogram predict survival of immune checkpoint inhibitor in non‐small‐cell lung cancer: Results from two multicenter, randomized clinical trials
Novel blood‐based tumor mutation algorithm and nomogram predict survival of immune checkpoint inhibitor in non‐small‐cell lung cancer: Results from two multicenter, randomized clinical trials Open
Dear Editor, Our previous study has demonstrated non-small-cell lung cancer (NSCLC) patients with high tissue-based tumor mutation burden (TMB) derived encouraging benefits from immune checkpoint inhibitor (ICI).1 The blood-based TMB (bTMB…
View article: Joint association of patients’ sex and PD‐L1 expression with overall survival benefits and tumor‐immune microenvironment in immune checkpoint inhibitors for cancers
Joint association of patients’ sex and PD‐L1 expression with overall survival benefits and tumor‐immune microenvironment in immune checkpoint inhibitors for cancers Open
Dear Editor, Currently, the association of patients' sex with survival benefit of immune checkpoint inhibitor (ICI) is being actively investigated, but inconsistent results have been produced. A meta-analysis1 reported that male patients h…
View article: Association of survival and genomic mutation signature with immunotherapy in patients with hepatocellular carcinoma
Association of survival and genomic mutation signature with immunotherapy in patients with hepatocellular carcinoma Open
Immunotherapy showed longer OS and PFS than conventional therapy among HCC patients, especially patients with a low mutation risk score. The nomogram based on genomic and clinical characteristics is effective in predicting survival of HCC …
View article: Association of Survival and Immune-Related Biomarkers With Immunotherapy in Patients With Non–Small Cell Lung Cancer
Association of Survival and Immune-Related Biomarkers With Immunotherapy in Patients With Non–Small Cell Lung Cancer Open
Immunotherapies showed promising clinical outcomes for patients with NSCLC. Pembrolizumab with platinum-based chemotherapy was found to be the most appropriate first-line immune checkpoint inhibitor regimen for advanced NSCLC, and the comb…