Dahua Chen
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View article: Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia
Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is a heterogeneous malignancy with low survival rates, primarily due to its inherent complexity. This underscores the urgent need to identify specific targets for precision medicine. Here, multi‐omics approache…
View article: A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides
A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides Open
Using density functional theory (DFT) and the information-theoretic approach (ITA) quantities to appreciate the energetics and properties of biopolymers is still an unaccomplished and ongoing task. To this end, we studied the building bloc…
View article: Identification of foam cell like M2 macrophages, AEBP1 biomarkers, and resveratrol as potential therapeutic in MASLD using Ecotyper and WGCNA
Identification of foam cell like M2 macrophages, AEBP1 biomarkers, and resveratrol as potential therapeutic in MASLD using Ecotyper and WGCNA Open
View article: Inhibition RIP1 prevents acute liver failure by suppressing hepatic apoptosis and attenuating the secretion of TNF-α from macrophages
Inhibition RIP1 prevents acute liver failure by suppressing hepatic apoptosis and attenuating the secretion of TNF-α from macrophages Open
View article: Association between Helicobacter pylori infection, serum thyroid-stimulating hormone, and thyroxine in the National Health and Nutrition Examination Survey 1999–2000
Association between Helicobacter pylori infection, serum thyroid-stimulating hormone, and thyroxine in the National Health and Nutrition Examination Survey 1999–2000 Open
Background Helicobacter pylori has been increasingly implicated in extra-gastric diseases. Current evidence regarding the association between serum thyroid-stimulating hormone (TSH), thyroxine (T4), and H. pylori infection remains inconclu…
View article: HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in<i>Drosophila</i>embryos
HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in<i>Drosophila</i>embryos Open
Early embryos undergo profound changes in their genomic architecture to establish the totipotent state, enabling pioneer factors to access chromatin and drive zygotic genome activation (ZGA). However, the mechanisms by which the totipotent…
View article: Tiny but mighty: Diverse functions of uORFs that regulate gene expression
Tiny but mighty: Diverse functions of uORFs that regulate gene expression Open
Upstream open reading frames (uORFs) are critical cis-acting regulators of downstream gene expression. Specifically, uORFs regulate translation by disrupting translation initiation or mediating mRNA decay. We herein summarize the ef…
View article: Causal effects of plasma metabolites on autoimmune hepatitis (AIH): a bidirectional two-sample mendelian randomization study
Causal effects of plasma metabolites on autoimmune hepatitis (AIH): a bidirectional two-sample mendelian randomization study Open
View article: Construction and validation of a prognostic signature based on anoikis-related lncRNAs in lung adenocarcinoma
Construction and validation of a prognostic signature based on anoikis-related lncRNAs in lung adenocarcinoma Open
Lung adenocarcinoma (LUAD) is the most common type of lung cancer and is characterized by a high death rate and a poor prospect for survival. Anoikis, which is a kind of programmed cell apoptosis, is an important factor in the advancement …
View article: The association between diverse serum folate with MAFLD and liver fibrosis based on NHANES 2017–2020
The association between diverse serum folate with MAFLD and liver fibrosis based on NHANES 2017–2020 Open
Background Metabolically Associated Fatty Liver Disease (MAFLD) marks a progression from the previous paradigm of Non-Alcoholic Fatty Liver Disease (NAFLD), presenting a redefined diagnostic framework that accentuates metabolic factors whi…
View article: Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function
Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function Open
Microglia are versatile regulators in brain development and disorders. Emerging evidence links microRNA (miRNA)-mediated regulation to microglial function; however, the exact underlying mechanism remains largely unknown. Here, we uncover t…
View article: The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development
The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development Open
Craniofacial microsomia (CFM) is a congenital defect that usually results from aberrant development of embryonic pharyngeal arches. However, the molecular basis of CFM pathogenesis is largely unknown. Here, we employ the zebrafish model to…
View article: Depression Exacerbates Hepatic Steatosis in C57BL/6J Mice by Activating the Hypothalamic-Pituitary-Adrenal Axis
Depression Exacerbates Hepatic Steatosis in C57BL/6J Mice by Activating the Hypothalamic-Pituitary-Adrenal Axis Open
Depression aggravated hepatic steatosis in CDAHFD-fed mice by activating the HPA axis. The risk of NAFLD development should be fully considered in depressive patients and improvement of psychotic disorders could be an etiological treatment…
View article: Pancancer analysis reveals the role of disulfidptosis in predicting prognosis, immune infiltration and immunotherapy response in tumors
Pancancer analysis reveals the role of disulfidptosis in predicting prognosis, immune infiltration and immunotherapy response in tumors Open
Disulfidptosis has been reported as a novel cell death process, suggesting a therapeutic strategy for cancer treatment. Herein, we constructed a multiomics data analysis to reveal the effects of disulfidptosis in tumors. Data for 33 kinds …
View article: PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling Open
TANK-binding kinase 1 (TBK1) is a key kinase in regulating antiviral innate immune responses. While the oligomerization of TBK1 is critical for its full activation, the molecular mechanism of how TBK1 forms oligomers remains unclear. Here,…
View article: Analysis of Genetic Diversity and Construction of a Core Collection of Ginkgo biloba Germplasm Using EST-SSR Markers
Analysis of Genetic Diversity and Construction of a Core Collection of Ginkgo biloba Germplasm Using EST-SSR Markers Open
Understanding genetic diversity and population structure is essential for the conservation and utilization of germplasm. Ginkgo biloba L. is a medicinal, edible and ornamental tree species. Detailed knowledge of genetic variability and div…
View article: Cdh1 plays a protective role in nonalcoholic fatty liver disease by regulating PPAR/PGC-1α signaling pathway
Cdh1 plays a protective role in nonalcoholic fatty liver disease by regulating PPAR/PGC-1α signaling pathway Open
The deletion of Cdh1 may promote Akt phosphorylation by up-regulating Skp2 and inhibit the PPAR/PGC-1α signaling pathway. Cdh1 serves a protective function in the occurrence and progression of NAFLD.
View article: The association between NAFLD and advanced liver fibrosis with urinary heavy metal based on the NHANES 2013-2018
The association between NAFLD and advanced liver fibrosis with urinary heavy metal based on the NHANES 2013-2018 Open
Background Chronic liver disease poses an escalating health challenge on a global scale. It has been suggested that prolonged exposure to heavy metals could potentially contribute to the development of non-alcoholic fatty liver disease (NA…
View article: Construction and Validation of a Prognostic Signature based on Anoikis- related lncRNAs in Lung Adenocarcinoma
Construction and Validation of a Prognostic Signature based on Anoikis- related lncRNAs in Lung Adenocarcinoma Open
Background Lung adenocarcinoma (LUAD) is the most prevalent form of lung cancer, with high mortality and poor prognosis. Anoikis, a type of programmed cell apoptosis, plays a vital role in the progression of tumors. Herein, we established …
View article: Identification of disease-related genes and construction of a gene co-expression database in non-alcoholic fatty liver disease
Identification of disease-related genes and construction of a gene co-expression database in non-alcoholic fatty liver disease Open
Background: The mechanism of NAFLD progression remains incompletely understood. Current gene-centric analysis methods lack reproducibility in transcriptomic studies. Methods: A compendium of NAFLD tissue transcriptome datasets was analyzed…
View article: The effect of synbiotics in patients with NAFLD: a systematic review and meta-analysis
The effect of synbiotics in patients with NAFLD: a systematic review and meta-analysis Open
Background: Nonalcoholic fatty liver disease (NAFLD) is the highest incidence of chronic liver disease worldwide, seriously endangering human health, and its pathogenesis is still unclear. In the recent years, increasing evidence has shown…
View article: The association between sleep duration, quality, and nonalcoholic fatty liver disease: A cross-sectional study
The association between sleep duration, quality, and nonalcoholic fatty liver disease: A cross-sectional study Open
Sleep can affect nonalcoholic fatty liver disease (NAFLD). We investigated the association between sleep duration, sleep quality, and NAFLD. From January to December 2018, 1,073 patients (age: 37.94 ± 10.88, Body Mass Index (BMI): 22.85 ± …
View article: Influence of foaming-induced crystallization behavior on the structure of PBAT supercritical foamed beads
Influence of foaming-induced crystallization behavior on the structure of PBAT supercritical foamed beads Open
The crystallization behavior during foaming directly affects the foaming properties. Double melting peaks were observed in the DSC curve of supercritical CO2 foamed PBAT beads. For crystalline polymers, there is no consensus on …
View article: <scp>RIG‐I</scp>‐mediated innate immune signaling in tumors reduces the therapeutic effect of oncolytic vesicular stomatitis virus
<span>RIG‐I</span>‐mediated innate immune signaling in tumors reduces the therapeutic effect of oncolytic vesicular stomatitis virus Open
Background Oncolytic viral therapy is a promising method for tumor treatment. Currently, several oncolytic viruses (OVs) have been used as tumor therapy at different phases of research and clinical trials. OVs not only directly lyse tumor …
View article: A protocol for mimicking lipid-mediated phase separation on the membrane using giant unilamellar vesicles
A protocol for mimicking lipid-mediated phase separation on the membrane using giant unilamellar vesicles Open
View article: Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase
Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase Open
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that plays a critical role in regulating antiviral signaling. cGAS binds to DNA and catalyzes the synthesis of cyclic GMP-AMP (cGAMP), which is essential for downstream signal transd…
View article: Argonaute-dependent ribosome-associated protein quality control
Argonaute-dependent ribosome-associated protein quality control Open
Ribosome-associated protein quality control (RQC) is a protein surveillance mechanism that eliminates defective nascent polypeptides. The E3 ubiquitin ligase, Ltn1, is a key regulator of RQC that targets substrates for ubiquitination. Argo…
View article: Optimized protocols for RNA-induced silencing complex assembly and cleavage in cultured Drosophila cells
Optimized protocols for RNA-induced silencing complex assembly and cleavage in cultured Drosophila cells Open
View article: A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides
A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides Open
Using density functional theory (DFT) and the information-theoretic approach (ITA) quantities to appreciate the energetics and properties of biopolymers is still an unaccomplished and ongoing task. To this end, we studied the building bloc…
View article: A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides
A Density Functional Theory and Information-Theoretic Approach Study of Interaction Energy and Polarizability for Base Pairs and Peptides Open
Using density functional theory (DFT) and the information-theoretic approach (ITA) quantities to appreciate the energetics and properties of biopolymers is still an unaccomplished and ongoing task. To this end, we studied the building bloc…