Yong Dai
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View article: A Multi-PTM omics atlas uncovers novel aging regulators in colorectal cancer
A Multi-PTM omics atlas uncovers novel aging regulators in colorectal cancer Open
Background Aging is a key driver of colorectal cancer (CRC) progression, yet the post-translational modification (PTM) landscape associated with aging in CRC remains largely uncharacterized. In particular, the coordinated influence of mult…
View article: A programmable mRNA platform for miRNA detection via miRNA-mRNA <sub>2</sub> triplex-mediated ribosomal frameshifting
A programmable mRNA platform for miRNA detection via miRNA-mRNA <sub>2</sub> triplex-mediated ribosomal frameshifting Open
Programmed −1 ribosomal frameshifting (−1 PRF) is a recoding mechanism utilized by viruses to expand their coding capacity and modulate the stoichiometric ratio of −1 frame and 0 frame translation products. The stability of mRNA secondary …
View article: Auto-US: An Ultrasound Video Diagnosis Agent Using Video Classification Framework and LLMs
Auto-US: An Ultrasound Video Diagnosis Agent Using Video Classification Framework and LLMs Open
AI-assisted ultrasound video diagnosis presents new opportunities to enhance the efficiency and accuracy of medical imaging analysis. However, existing research remains limited in terms of dataset diversity, diagnostic performance, and cli…
View article: Comprehensive analysis of LncRNA-miRNA-mRNA CeRNA network associated with umbilical cord blood PBMC in down syndrome
Comprehensive analysis of LncRNA-miRNA-mRNA CeRNA network associated with umbilical cord blood PBMC in down syndrome Open
Down syndrome (DS), a typical chromosomal disease caused by all or part of an extra genomic copy of chromosome 21. Few reports have investigated roles of competing endogenous RNA (ceRNA)-mediated regulatory mechanisms in DS pathogenesis. R…
View article: Investigating the platelet autophagy effect in maintenance hemodialysis patients by whole genome transcriptome from platelets
Investigating the platelet autophagy effect in maintenance hemodialysis patients by whole genome transcriptome from platelets Open
Thrombosis and hemorrhage are common complications in maintenance hemodialysis (MHD) patients, potentially attributed to platelet dysfunction. This study aimed to investigate platelet autophagy in MHD patients through whole transcriptome s…
View article: UniAPL: A Unified Adversarial Preference Learning Framework for Instruct-Following
UniAPL: A Unified Adversarial Preference Learning Framework for Instruct-Following Open
Shaping powerful LLMs to be beneficial and safe is central to AI alignment. We argue that post-training alignment is fundamentally a unified Preference Learning problem, involving two modalities: demonstrated preferences (e.g., Supervised …
View article: Triclabendazole inhibits PKM2 nuclear localization and glycolysis by enhancing HDAC6-mediated deacetylation in lung cancer
Triclabendazole inhibits PKM2 nuclear localization and glycolysis by enhancing HDAC6-mediated deacetylation in lung cancer Open
Our findings revealed that triclabendazole inhibits PKM2 nuclear localization and glycolysis through an HDAC6-dependent mechanism, leading to the activation of AMPK/mTOR signaling and suppression of lung cancer cell proliferation. These re…
View article: Copper-catalyzed Oxidation C(sp3)–H Difunctionalization of Xanthene Derivatives to Construct Triaryl Tertiary Alcohols
Copper-catalyzed Oxidation C(sp3)–H Difunctionalization of Xanthene Derivatives to Construct Triaryl Tertiary Alcohols Open
View article: Association between age-related cardiovascular disease and systemic lupus erythematosus: a Mendelian randomization analysis
Association between age-related cardiovascular disease and systemic lupus erythematosus: a Mendelian randomization analysis Open
JOURNAL/agad/04.03/02274129-202512000-00002/figure1/v/2025-10-03T110810Z/r/image-tiff Current research has demonstrated that individuals with systemic lupus erythematosus face a markedly greater risk of cardiovascular disease. However, the…
View article: Correction: miR-29a-5p regulates the proliferation, invasion, and migration of gliomas by targeting DHRS4
Correction: miR-29a-5p regulates the proliferation, invasion, and migration of gliomas by targeting DHRS4 Open
[This corrects the article DOI: 10.3389/fonc.2020.01772.].
View article: Resource-Efficient Cotton Network: A Lightweight Deep Learning Framework for Cotton Disease and Pest Classification
Resource-Efficient Cotton Network: A Lightweight Deep Learning Framework for Cotton Disease and Pest Classification Open
Cotton is the most widely cultivated natural fiber crop worldwide, yet it is highly susceptible to various diseases and pests that significantly compromise both yield and quality. To enable rapid and accurate diagnosis of cotton diseases a…
View article: Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions
Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions Open
Peptide nucleic acid (PNA), a synthetic nucleic acid analog, exhibits substantial potential in biotechnology and therapeutic applications due to its high binding affinity and nuclease/protease resistance. Chemically modified PNAs capable o…
View article: Author Correction: Proteomic analysis of laser captured tubular tissues reveals complement activation and mitochondrial dysfunction in autoimmune related kidney diseases
Author Correction: Proteomic analysis of laser captured tubular tissues reveals complement activation and mitochondrial dysfunction in autoimmune related kidney diseases Open
View article: Single cell transcription revealing key transcription factors in embryonic kidney development
Single cell transcription revealing key transcription factors in embryonic kidney development Open
View article: Federated learning-based virtual dual-energy CT generation from single-energy CT for gout detection
Federated learning-based virtual dual-energy CT generation from single-energy CT for gout detection Open
Objective This study aims to develop and validate OneGout, a federated learning (FL)-based framework for early and accurate gout diagnosis to address the limitations of current diagnostic methods, specifically the invasiveness of joint asp…
View article: Proteomic Insights into IgA Nephropathy: A Comprehensive Analysis of Differentially Expressed Proteins in the Kidney
Proteomic Insights into IgA Nephropathy: A Comprehensive Analysis of Differentially Expressed Proteins in the Kidney Open
IgA nephropathy represents a significant challenge in nephrology research, and an understanding of its underlying molecular mechanisms is crucial. In this study, we conducted a comprehensive proteomic investigation of IgA nephropathy utili…
View article: IL-6 Affects Liver Metabolic Abnormalities Caused by Silicon Exposure by Regulating the PKC/YY1 Signaling Pathway
IL-6 Affects Liver Metabolic Abnormalities Caused by Silicon Exposure by Regulating the PKC/YY1 Signaling Pathway Open
Background: This study aims to investigate the impact of coal dust (silicon dioxide) exposure on dyslipidemia and its underlying mechanisms, with a focus on the association between coal dust exposure and hepatic metabolic disorders. Method…
View article: Comprehensive analysis of eccDNA characteristics and associated genes expression in peripheral blood of ASLE and ISLE patients
Comprehensive analysis of eccDNA characteristics and associated genes expression in peripheral blood of ASLE and ISLE patients Open
To explore SLE staging markers, we analyzed eccDNA in plasma using circular sequencing, comparing healthy controls (HC), active SLE (ASLE), and inactive SLE (ISLE) patients. We found higher eccDNA levels and lower GC content in ASLE and IS…
View article: Global trends of depressive disorders among women of reproductive age from 1990 to 2021: a systematic analysis of burden, sociodemographic disparities, and health workforce correlations
Global trends of depressive disorders among women of reproductive age from 1990 to 2021: a systematic analysis of burden, sociodemographic disparities, and health workforce correlations Open
View article: Applications and prospects of phosphoproteomics in renal disease research
Applications and prospects of phosphoproteomics in renal disease research Open
Introduction Phosphoproteomics, an advanced branch of molecular biology, utilizes specific techniques such as mass spectrometry, affinity chromatography, and bioinformatics analysis to explore protein phosphorylation, shedding light on the…
View article: Identification of proteome-wide and functional analysis of lysine crotonylation in multiple organs of the human fetus
Identification of proteome-wide and functional analysis of lysine crotonylation in multiple organs of the human fetus Open
Lysine crotonylation (Kcr) is a novel post-translational modification that is important in functional studies. However, our understanding of Kcr in the developing human fetus brain, heart, kidney, liver, and lung remains restricted. In thi…
View article: Quercitrin, the primary active ingredient of Albizia julibrissin Durazz. flowers, alleviates methamphetamine-induced hepatotoxicity through a mitochondria-mediated apoptosis pathway
Quercitrin, the primary active ingredient of Albizia julibrissin Durazz. flowers, alleviates methamphetamine-induced hepatotoxicity through a mitochondria-mediated apoptosis pathway Open
Background and purpose Methamphetamine (METH), a synthetic psychostimulant and highly addictive drug, could cause depression and acute liver injury. There have been few studies on the mechanism by which METH induces liver damage and on how…
View article: Artificial Intelligence-Driven Wireless Sensing for Health Management
Artificial Intelligence-Driven Wireless Sensing for Health Management Open
(1) Background: With technological advancements, the integration of wireless sensing and artificial intelligence (AI) has significant potential for real-time monitoring and intervention. Wireless sensing devices have been applied to variou…
View article: IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis Open
View article: Strategy optimization method based on UAVs‐assisted detection of covert communication
Strategy optimization method based on UAVs‐assisted detection of covert communication Open
Unmanned aerial vehicles (UAVs) are highly mobile and easily deployable devices that have become an important component of wireless communication countermeasures. Covert communication, the main method used to ensure wireless communication …
View article: TMT-based quantitative proteomics and non-targeted metabolomics reveal the antibacterial mechanism of rhein against Bacillus cereus and its potential application as a food preservative
TMT-based quantitative proteomics and non-targeted metabolomics reveal the antibacterial mechanism of rhein against Bacillus cereus and its potential application as a food preservative Open
View article: Learn to Optimize Resource Allocation under QoS Constraint of AR
Learn to Optimize Resource Allocation under QoS Constraint of AR Open
This paper studies the uplink and downlink power allocation for interactive augmented reality (AR) services, where the live video captured by an AR device is uploaded to the network edge, and then the augmented video is subsequently downlo…
View article: scRNA-seq reveals involvement of monocytes in immune response in SLE patients
scRNA-seq reveals involvement of monocytes in immune response in SLE patients Open
Our results demonstrate upregulation of monocyte inflammation in circulating immune cells in SLE patients and expands the current understanding of circulating immune cells in SLE. Our study provides a blueprint for future exploration of SL…
View article: Nab-paclitaxel plus cisplatin versus gemcitabine plus cisplatin as first-line treatment in advanced biliary tract cancer: results of a multicentre, randomised, phase II trial
Nab-paclitaxel plus cisplatin versus gemcitabine plus cisplatin as first-line treatment in advanced biliary tract cancer: results of a multicentre, randomised, phase II trial Open
Background: the efficacy and safety of conventional first-line chemotherapeutic regimens for the treatment of advanced biliary tract carcinomas (ABTCs) have been unsatisfactory. Objectives: We aimed to explore alternative chemotherapeutic …
View article: RUL Prediction Based on MBGD-WGAN-GRU for Lithium-Ion Batteries
RUL Prediction Based on MBGD-WGAN-GRU for Lithium-Ion Batteries Open
To address the challenges associated with acquiring complete charge-discharge cycle data and extracting health indicator factors (IHFs) from fragmented datasets in current automotive lithium-ion batteries (LIBs), this study proposes a nove…