Daichi Ishikawa
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View article: Usefulness of transanal approach for lower rectal cancer: a propensity score-matched analysis
Usefulness of transanal approach for lower rectal cancer: a propensity score-matched analysis Open
Aim: Transanal approaches, such as transanal total mesorectal excision and transperineal abdominoperineal resection, have been developed to improve surgical quality for lower rectal cancer. However, international concerns have been raised …
View article: Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells
Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells Open
Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation. Epigenetic changes affecting glucose metabolism in cancer‐…
View article: Transperineal approach alone as minimally invasive surgery for pelvic recurrence of rectal cancer after abdominoperineal resection
Transperineal approach alone as minimally invasive surgery for pelvic recurrence of rectal cancer after abdominoperineal resection Open
Introduction: In this report, we describe a case of pelvic recurrence of rectal cancer invading a seminal vesicle after abdominoperineal resection, which was removed only by a transperineal approach with the addition of urethrography. Case…
View article: Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer
Lymphocyte to C-reactive protein ratio predicts long-term outcomes for patients with lower rectal cancer Open
Backgrounds The lymphocyte to C-reactive protein (CRP) ratio (LCR) is an indicator of systemic inflammation and host–tumor cell interactions. The aim of this study was to investigate the prognostic significance of LCR in lower rectal cance…
View article: Combination of dirty mass volume and APACHE II score predicts mortality in patients with colorectal perforation
Combination of dirty mass volume and APACHE II score predicts mortality in patients with colorectal perforation Open
Background “Dirty mass” is a specific computed tomography (CT) finding that is seen frequently in colorectal perforation. The prognostic significance of this finding for mortality is unclear. Methods Fifty-eight consecutive patients with c…
View article: Combination of dirty mass volume and APACHE II score predicts mortality in patients with colorectal perforation
Combination of dirty mass volume and APACHE II score predicts mortality in patients with colorectal perforation Open
Background : “Dirty mass” is a specific computed tomography (CT) finding that is seen frequently in colorectal perforation. The prognostic significance of this finding for mortality is unclear. Methods : Fifty-eight consecutive patients wi…
View article: Combination of Dirty Mass Volume and APACHE II Score Predicts Mortality in Patients with Colorectal perforation
Combination of Dirty Mass Volume and APACHE II Score Predicts Mortality in Patients with Colorectal perforation Open
Background: “Dirty mass” is a specific computed tomography (CT) finding that is seen frequently in colorectal perforation. The prognostic significance of this finding for mortality is unclear. Methods: Fifty-eight consecutive patients with…
View article: Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes
Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes Open
Background The cytokine IL-17 is a key player in autoimmune processes, while the cytokine IL-6 is responsible for the chronification of inflammation. However, their roles in type 1 diabetes development are still unknown. Methods Therefore,…
View article: Anastomotic recurrence after laparoscopic distal gastrectomy with delta-shaped anastomosis : report of a case
Anastomotic recurrence after laparoscopic distal gastrectomy with delta-shaped anastomosis : report of a case Open
Delta-shaped anastomosis is nowadays an increasingly performed reconstruction method in laparoscopic distal gastrectomy for early gastric cancer. To date, anastomotic recurrence at the delta-shaped anastomotic site has not been reported. S…
View article: Usefulness of an ICG fluorescence catheter system in TaTME for avoiding intraoperative urethral injury
Usefulness of an ICG fluorescence catheter system in TaTME for avoiding intraoperative urethral injury Open
ICG fluorescent catheter system may be useful for avoiding intraoperative urethral injury in TaTME. J. Med. Invest. 67 : 285-288, August, 2020.
View article: The Role of Neutrophil-to-lymphocyte Ratio on the Effect of CRT for Patients With Rectal Cancer
The Role of Neutrophil-to-lymphocyte Ratio on the Effect of CRT for Patients With Rectal Cancer Open
NLR after preoperative CRT could be a potential prognostic indicator for patients with lower rectal cancer.
View article: A Re-recurrent Case of Inguinal Bladder Hernia Treated by Transabdominal Preperitoneal Repair
A Re-recurrent Case of Inguinal Bladder Hernia Treated by Transabdominal Preperitoneal Repair Open
症例は69歳,男性.57歳と64歳時に右鼠径部ヘルニア修復術の既往あり.半年前から右鼠径部の膨隆を認め,当科を受診した.鼠径部除圧下腹臥位CT検査で右下腹壁動静脈の内側から膀胱の右前壁の脱出を認め,膀胱ヘルニアと診断し,TAPP法を施行した.手術所見では前回挿入されたUPPが右内鼠径輪に展開され,右下腹壁動静脈内側に陥凹を認め,日本ヘルニア学会鼠径部ヘルニア分類ではRec II-3,膀胱ヘルニア分類ではparaperitoneal type(腹膜側型)であった.Bard®3…
View article: Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer
Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer Open
The miR-449a level in tumor tissue might be useful as a prognostic indicator for patients with gastric cancer and miR-449a in serum appears to reflect its expression in tumor tissue.
View article: The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer
The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer Open
miR-449a level might be a prognostic indicator for colorectal cancer and miR-449a might regulate HDAC1 expression.
View article: Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons
Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons Open
Purpose The aim of this study was to investigate the utility the three-dimensional (3D) imaging for laparoscopic gastrectomy performed by trainee surgeons. Methods 3D-reconstruction was performed using multi-detector computed tomography (M…
View article: A Case of Traumatic Abdominal Wall Hernia Repaired by Laparoscopic Surgery
A Case of Traumatic Abdominal Wall Hernia Repaired by Laparoscopic Surgery Open
症例は84歳,男性.はしごより転落し,木の切り株で右側腹部を打撲した.その後,右側腹部の膨隆を主訴に同日受診した.右側腹部に打撲痕と径15cm大の膨隆を認めた.腹部CT検査で右側腹部に内外腹斜筋・腹横筋の断裂を認め,4×9cm長のヘルニア門で大網・横行結腸を内容物とする右側腹部腹壁ヘルニアを認めた.以上より外傷性腹壁ヘルニアの診断で嵌頓所見を認めず,腹腔内損傷が軽度であったため,待機手術の方針とした.手術は腹腔鏡下にヘルニア門を同定し,intraperitoneal onl…
View article: SPH SIMULATION OF ARATOZAWA LANDSLIDE CONSIDERING ARTIFICIAL VISCOSITY
SPH SIMULATION OF ARATOZAWA LANDSLIDE CONSIDERING ARTIFICIAL VISCOSITY Open
本研究では,地すべり崩土到達距離の推定手法としてSPH法の適用性を示すことを目的に,荒砥沢地すべりを対象とした2次元の再現解析を行った.流動量が実被害に比べ過少評価される原因として人工粘性を挙げ,その影響を感度分析した.その結果,SPH法による地すべりの流動量評価において,人工粘性が流動量へ影響を与えることを示した.また,荒砥沢地すべりの発生機構として,すべり層である砂岩・シルト岩が地震時の間隙水圧に伴いせん断強度が低下したことが考えられ,残留内部摩擦角を見かけの内部摩擦角…
View article: Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy
Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy Open
EGCG increased the sensitivity of colorectal cancer cells to radiation by inhibiting cell proliferation and inducing Nrf2 nuclear translocation and autophagy.
View article: The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer
The Impact of Indoleamine 2,3-dioxygenase (IDO) Expression on Stage III Gastric Cancer Open
IDO is associated with poor prognosis and immuno-tolerance through attenuation of Treg activation in Stage III GC.
View article: Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer
Programmed Cell Death Ligand 1 Expression Is an Independent Prognostic Factor in Colorectal Cancer Open
PD-1 and PD-L1 expressions were associated with a poor prognosis and correlated with TGF-β and Foxp3 expressions in patients with CRC.
View article: The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy
The Outcome of Sorafenib Therapy on Unresectable Hepatocellular Carcinoma: Experience of Conversion and Salvage Hepatectomy Open
Sorafenib combined with surgical resection is a feasible option in advanced HCC patients, if sorafenib has been effective.
View article: Results of Hepatic Resection for Liver Metastasis of Gastric Cancer
Results of Hepatic Resection for Liver Metastasis of Gastric Cancer Open
Hepatic resection for GLM has an acceptable outcome. Metachronous hepatic resection tends to have a better outcome than synchronous hepatic resection for the treatment of GLM. J. Med. Invest. 65:27-31, February, 2018.
View article: High STAT4 Expression Indicates Better Disease-free Survival in Patients with Gastric Cancer
High STAT4 Expression Indicates Better Disease-free Survival in Patients with Gastric Cancer Open
High expression of STAT4 in gastric cancer predicted a better clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after gastrectomy.
View article: miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions
miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions Open
Pluripotent stem cells hold great promise for regenerative medicine since they can differentiate into all somatic cells. MicroRNAs (miRNAs) could be important for the regulation of these cell-fate decisions. Profiling of miRNAs revealed 19…
View article: Peripheral Tr1 and Foxp3+ Treg as Markers of Recurrent Malignancies in Patients with Hepato-Biliary Pancreatic Cancers
Peripheral Tr1 and Foxp3+ Treg as Markers of Recurrent Malignancies in Patients with Hepato-Biliary Pancreatic Cancers Open
Peripheral Tregs and Tr1 indicate immunological state against cancer.
View article: Correlation Between Thrombospondin-1 Expression in Non-cancer Tissue and Gastric Carcinogenesis
Correlation Between Thrombospondin-1 Expression in Non-cancer Tissue and Gastric Carcinogenesis Open
Expression of TSP1 in non-cancer tissue correlated with gastric carcinogenesis.
View article: Maximum Diameter and Number of Tumors as a New Prognostic Indicator of Colorectal Liver Metastases
Maximum Diameter and Number of Tumors as a New Prognostic Indicator of Colorectal Liver Metastases Open
MDN ≥30 is an independent prognostic factor of survival in patients with CRLM and optimal surgical criterion of hepatectomy for CRLM.