Daichi Maeda
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View article: Molecular characterization of chronic inflammatory diseases of the urinary bladder based on next-generation RNA sequencing and digital image analysis
Molecular characterization of chronic inflammatory diseases of the urinary bladder based on next-generation RNA sequencing and digital image analysis Open
This study aimed to elucidate distinct cellular and immunological characteristics associated with chronic inflammatory conditions of the urinary bladder, including Hunner-type interstitial cystitis (HIC), bacillus Calmette-Guérin (BCG)-rel…
View article: Pathological Angiogenesis Precedes the Onset of Aortic Dissection
Pathological Angiogenesis Precedes the Onset of Aortic Dissection Open
Summary Aortic dissection (AD) is a severe, life-threatening disease that occurs abruptly 1 . Although remodeling and inherent vulnerability of the aortic media, as observed in heritable connective tissue disorders such as Marfan syndrome,…
View article: A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters
A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters Open
Introduction Interstitial cystitis with Hunner lesion (IC/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported the IC/HL involving the upper urinary tract. Case Presentation A 51‐year…
View article: Characterizing the tumor immune environment in thymic epithelial tumors using T-cell receptor repertoire analysis and gene expression profiling
Characterizing the tumor immune environment in thymic epithelial tumors using T-cell receptor repertoire analysis and gene expression profiling Open
Multiple immunological approaches to evaluate the tumor immune environment and immunogenomic profile of thymoma reveal a diverse and complex immune environment. B3 thymomas, despite being T-cell depleted, exhibit increased T-cell receptor …
View article: Clinical manifestations of interstitial cystitis and bladder pain syndrome: Analysis of a patient registry in Japan
Clinical manifestations of interstitial cystitis and bladder pain syndrome: Analysis of a patient registry in Japan Open
Objective To describe clinical manifestations of patients with interstitial cystitis and bladder pain syndrome (IC/BPS) using a patient registry in Japan. Methods This retrospective cohort study utilized a patient registry supported by the…
View article: Low CD86 expression is a predictive biomarker for clinical response to the therapeutic human papillomavirus vaccine IGMKK16E7: results of a post hoc analysis
Low CD86 expression is a predictive biomarker for clinical response to the therapeutic human papillomavirus vaccine IGMKK16E7: results of a post hoc analysis Open
Background Although therapeutic human papillomavirus vaccines could offer a noninvasive treatment for patients with cervical intraepithelial neoplasia, none has been clinically implemented. Oral administration of the therapeutic human papi…
View article: Integrated genomic/epigenomic analysis stratifies subtypes of clear cell ovarian carcinoma, highlighting their cellular origin
Integrated genomic/epigenomic analysis stratifies subtypes of clear cell ovarian carcinoma, highlighting their cellular origin Open
View article: Prognostic value of CAF marker expression in the intratumoral and marginal areas of soft tissue sarcoma
Prognostic value of CAF marker expression in the intratumoral and marginal areas of soft tissue sarcoma Open
Introduction: The tumor microenvironment of sarcomas has not been studied in detail; in particular, little is known about cancer-associated fibroblasts (CAFs). Sarcoma cells are difficult to distinguish from CAFs, either histomorphological…
View article: Research autopsy programmes in oncology: shared experience from 14 centres across the world
Research autopsy programmes in oncology: shared experience from 14 centres across the world Open
While there is a great clinical need to understand the biology of metastatic cancer in order to treat it more effectively, research is hampered by limited sample availability. Research autopsy programmes can crucially advance the field thr…
View article: Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses Open
View article: Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis
Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis Open
Hunner-type interstitial cystitis (HIC) is a rare, enigmatic inflammatory disease of the urinary bladder with no curative treatments. In this study, we aimed to characterize the unique cellular and immunological factors specifically involv…
View article: Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis
Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis Open
Hunner-type interstitial cystitis (HIC) is a rare, chronic inflammatory disease of the urinary bladder with unknown etiology and genetic background. Here, we conduct a genome-wide association study of 144 patients with HIC and 41,516 contr…
View article: Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Models of PMC-mediated gastric cancer progression.
View article: Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Effects of ALDH inhibition on cancer cells, PMCs and CAFs.
View article: Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Wnt3a-mediated PMC infiltration was blocked byDKK1183-266.
View article: Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Models of PMC-mediated gastric cancer progression.
View article: Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Cancer cell-released CD63-containing EVs are diffused in the stomach.
View article: Supplementary Figure 3 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 3 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Wnt3a attracts PMC migration.
View article: Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer
Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer Open
The transcription factor E74-like factor 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role of ELF3 in bile duct cells by identifying several previously unk…
View article: Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Effects of ALDH inhibition on cancer cells, PMCs and CAFs.
View article: Supplementary Materials and Methods from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Materials and Methods from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Materials and Methods not included in the text
View article: Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Peritoneal metastasis of human gastric cancer, and effects of ALDH inhibition on tumor growth.
View article: Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Wnt3a-mediated PMC infiltration was blocked byDKK1183-266.
View article: Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Peritoneal metastasis of human gastric cancer, and effects of ALDH inhibition on tumor growth.
View article: Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Cancer cell-released CD63-containing EVs are diffused in the stomach.
View article: Data from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Data from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Peritoneal mesothelial cells (PMC) cover organ surfaces in the abdominal cavity. In this study, lineage tracing revealed that the PMCs guide cancer cell invasion in the gastric wall and in peritoneal metastatic lesions. Serosal PMCs coveri…
View article: Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer
Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer Open
The transcription factor E74-like factor 3 (ELF3) is inactivated in a range of cancers, including biliary tract cancer (BTC). Here, we investigated the tumor-suppressive role of ELF3 in bile duct cells by identifying several previously unk…
View article: Supplementary Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer
Supplementary Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer Open
Supplemental experimental procedures, Figure S1-S16, Table S5
View article: Supplementary Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer
Supplementary Data from E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer Open
Supplemental experimental procedures, Figure S1-S16, Table S5
View article: Supplementary Figure 1 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 1 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Ki-67 immunostaining of PMCs and PMC infiltration into OCUM2MD3-inoculated stomach.