Daiqing Liao
YOU?
Author Swipe
View article: Proteolysis targeting chimera extracellular vesicles for therapeutic development treating triple negative breast cancer
Proteolysis targeting chimera extracellular vesicles for therapeutic development treating triple negative breast cancer Open
Proteolysis targeting chimeras (PROTACs) are an emerging targeted cancer therapy approach, but wide-spread clinical use of PROTAC is limited due to poor cell targeting and penetration, and instability in vivo. To overcome such issues and e…
View article: Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8 Open
HDAC8 plays crucial roles in biological processes, from gene regulation to cell motility, making it a highly desirable target for therapeutic intervention. HDAC8 also has deacetylase-independent activity which cannot be blocked by a conven…
View article: Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy Open
Immune checkpoint inhibitors (ICIs) use antibodies that block cell surface immune checkpoint proteins with great efficacy in treating immunogenic or “immune hot” tumors such as melanoma, kidney, and lung adenocarcinoma. ICIs have limited r…
View article: DAXX drives de novo lipogenesis and contributes to tumorigenesis
DAXX drives de novo lipogenesis and contributes to tumorigenesis Open
Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in lipid production are highly upregulated, but the mechanisms that control their expression remain poorly understood. Using integrated transcr…
View article: Data from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
Data from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents Open
Acetyltransferase p300 (KAT3B) plays key roles in signaling cascades that support cancer cell survival and sustained proliferation. Thus, p300 represents a potential anticancer therapeutic target. To discover novel anticancer agents that t…
View article: Supplementary Methods from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
Supplementary Methods from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents Open
PDF file - 36K
View article: Data from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
Data from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents Open
Acetyltransferase p300 (KAT3B) plays key roles in signaling cascades that support cancer cell survival and sustained proliferation. Thus, p300 represents a potential anticancer therapeutic target. To discover novel anticancer agents that t…
View article: Supplementary Methods from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
Supplementary Methods from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents Open
PDF file - 36K
View article: Supplementary Figures 1 - 7, Table 1 from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
Supplementary Figures 1 - 7, Table 1 from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents Open
PDF file - 456K, Table S1: Growth inhibition of NCI-60 panel of cancer cell lines by L002 (NSC764414); Supplemental Figure 1: Distribution of hits in the primary potentiator screen ; Supplemental Figure 2: Hit distribution in the primary a…
View article: Supplementary Figures 1 - 7, Table 1 from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
Supplementary Figures 1 - 7, Table 1 from Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents Open
PDF file - 456K, Table S1: Growth inhibition of NCI-60 panel of cancer cell lines by L002 (NSC764414); Supplemental Figure 1: Distribution of hits in the primary potentiator screen ; Supplemental Figure 2: Hit distribution in the primary a…
View article: Supplementary Figures 3-6 from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis
Supplementary Figures 3-6 from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis Open
Supplementary Figures 3-6 from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis
View article: Data from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis
Data from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis Open
In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. EBF3 is expressed in normal brain but is silenc…
View article: Data from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis
Data from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis Open
In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. EBF3 is expressed in normal brain but is silenc…
View article: Supplementary Figures 3-6 from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis
Supplementary Figures 3-6 from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis Open
Supplementary Figures 3-6 from An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis
View article: CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers
CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers Open
The CREB-binding protein (CBP) and p300 are two paralogous lysine acetyltransferases (KATs) that were discovered in the 1980s–1990s. Since their discovery, CBP/p300 have emerged as important regulatory proteins due to their ability to acet…
View article: Pharmacological Inhibition of CBP/p300 Blocks Estrogen Receptor Alpha (ERα) Function through Suppressing Enhancer H3K27 Acetylation in Luminal Breast Cancer
Pharmacological Inhibition of CBP/p300 Blocks Estrogen Receptor Alpha (ERα) Function through Suppressing Enhancer H3K27 Acetylation in Luminal Breast Cancer Open
Estrogen receptor alpha (ER) is the oncogenic driver for ER+ breast cancer (BC). ER antagonists are the standard-of-care treatment for ER+ BC; however, primary and acquired resistance to these agents is common. CBP and p300 are critical ER…
View article: The DAXX-SREBP axis promotes oncogenic lipogenesis and tumorigenesis
The DAXX-SREBP axis promotes oncogenic lipogenesis and tumorigenesis Open
De novo lipogenesis produces lipids for membrane biosynthesis and cell signaling. Elevated lipogenesis is a major metabolic feature in cancer cells. In breast and other cancer types, genes involved in lipogenesis are highly upregulated, bu…
View article: The Effects of Histone Deacetylase (HDAC) Inhibitors on FASN Intracellular Localization in Cancer Cells
The Effects of Histone Deacetylase (HDAC) Inhibitors on FASN Intracellular Localization in Cancer Cells Open
Understanding mechanisms underlying cancer biology is crucial for discovering novel and effective therapies to improve patient outcome. Increased lipid production is a major metabolic feature in cancer. The fatty acid synthase (FASN) is a …
View article: Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs
Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs Open
Potent and histone deacetylase 3 (HDAC3)-specific PROTAC XZ9002 is reported here.
View article: DAXX in cancer: phenomena, processes, mechanisms and regulation
DAXX in cancer: phenomena, processes, mechanisms and regulation Open
DAXX displays complex biological functions. Remarkably, DAXX overexpression is a common feature in diverse cancers, which correlates with tumorigenesis, disease progression and treatment resistance. Structurally, DAXX is modular with an N-…
View article: Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival
Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival Open
Background Mutations or truncation of the ligand‐binding domain (LBD) of androgen receptor (AR) underlie treatment resistance for prostate cancer (PCa). Thus, targeting the AR N‐terminal domain (NTD) could overcome such resistance. Methods…
View article: Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis
Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis Open
Cancer cells of epithelial and mesenchymal phenotypes exhibit different sensitivities to apoptosis stimuli, but the mechanisms underlying this phenomenon remain partly understood. We constructed a novel recombinant adenovirus expressing Ad…