Explanipedia

Does PSA Nadir + 2 ng/mL Always Indicate Biochemical Recurrence? A PSA Kinetics-Based Evaluation Following Carbon Ion Radiotherapy for Localized High-Risk Prostate Cancer Open

Satoshi Shima, Yosuke Takakusagi, Tatsuya Okuda, Hiroaki Koge, Kio Kano , et al. · 2025

Background: Biochemical recurrence after radiotherapy for prostate cancer is commonly defined by the Phoenix criteria (prostate-specific antigen [PSA] nadir + 2 ng/mL). However, some patients experience PSA elevation without clinical recur…

Target Coverage Improvement With Dose Matching in Carbon-Ion Radiation Therapy for Pancreatic Cancer Open

Yohsuke Kusano, Hiroyuki Katoh, Yoshiki Takayama, Junya Nagata, Shogo Kurokawa , et al. · 2025

Carbon-Ion Radiotherapy as a Local Treatment Option for Hepatocellular Carcinoma With Child-Pugh Class B Cirrhosis Open

Shintaro Shiba, Keisuke Tsuchida, Nobutaka Mizoguchi, Shohei Kawashiro, Satoshi Shima , et al. · 2025

Nivolumab in Combination with Radiotherapy for Unresectable Advanced or Recurrent Gastric Cancer (Circuit Trial): A 3-Year Update of the Progression-Free Survival and Local Control Outcomes Open

Yoshiyuki Suzuki, Daisaku Yoshida, Kosaku Mimura, Takashi Ogata, Yuya Yoshimoto , et al. · 2025

Trends and Issues of Foreign Patients Undergoing Plastic Surgery Over the Past 15 Years Open

Kohei Fujiwara, Kentaro Yoshino, Daisaku Yoshida · 2025

Adjuvant Therapy with Immune Checkpoint Inhibitors after Carbon Ion Radiotherapy for Mucosal Melanoma of the Head and Neck: A Case-Control Study Open

Nobutaka Mizoguchi, Kio Kano, Tatsuya Okuda, Hiroaki Koge, Satoshi Shima , et al. · 2024

The development of new treatment strategies to improve the prognosis of mucosal malignant melanoma of the head and neck (MMHN) after carbon ion radiotherapy (CIRT) is essential because of the risk of distant metastases. Therefore, our obje…

Preliminary result of combined treatment with scanning carbon-ion radiotherapy and image-guided brachytherapy for locally advanced cervical adenocarcinoma Open

Keisuke Tsuchida, Daisaku Yoshida, Satoshi Shima, Terufumi Kusunoki, Yoshiki Takayama , et al. · 2024

Although there is growing evidence of the efficacy of carbon-ion radiotherapy (CIRT) for locally advanced cervical adenocarcinoma, reports on combined treatment with CIRT and image-guided brachytherapy (IGBT) are scarce. We retrospectively…

Are prophylactic antibiotics required for combined intracavitary and interstitial brachytherapy of gynecologic cancers? Open

Takuya Kumazawa, Yu Ohkubo, Keishiro Mochida, Saori Kondo, Osamu Oguchi , et al. · 2024

The purpose of this study is to evaluate the need for prophylactic antibiotic treatment prior to combined intracavitary and interstitial (hybrid) brachytherapy for gynecologic cancer. A total of 105 gynecologic cancer patients received 405…

Five-year clinical outcomes of scanning carbon-ion radiotherapy for prostate cancer Open

Yosuke Takakusagi, Hiroaki Koge, Kio Kano, Satoshi Shima, Keisuke Tsuchida , et al. · 2024

Background Carbon-ion radiotherapy (CIRT) has been associated with favorable clinical outcomes in patients with prostate cancer. At our facility, all patients are treated using scanning CIRT (sCIRT). We retrospectively analyzed five-year c…

Combination of oligo-fractionated irradiation with nivolumab can induce immune modulation in gastric cancer Open

Kosaku Mimura, Takashi Ogata, Phuong H. D. Nguyen, Roy S, Hassen Kared , et al. · 2024

Background Tumor-associated antigen (TAA)-specific CD8(+) T cells are essential for nivolumab therapy, and irradiation has been reported to have the potential to generate and activate TAA-specific CD8(+) T cells. However, mechanistic insig…

Five-Year Survival Outcomes After Carbon-Ion Radiotherapy for Operable Stage I NSCLC: A Japanese National Registry Study (J-CROS-LUNG) Open

Nobuteru Kubo, Hiroaki Suefuji, Mio Nakajima, Sunao Tokumaru, Naoko Okano , et al. · 2023

This study reports the long-term outcomes of CIRT for operable NSCLC in the real world. CIRT for operable patients has been found to have favorable outcomes, with tolerable toxicity.

Planning strategies for robust carbon-ion scanning radiotherapy for stage I esophageal cancer: a retrospective study Open

Makito Suga, Yohsuke Kusano, Yosuke Takakusagi, Yukio Oosawa, Shinichi Minohara , et al. · 2023

This study aimed to establish a treatment planning strategy with carbon-ion scanning radiotherapy (CIRTs) for stage I esophageal cancer. The clinical data of seven patients treated with CIRTs were used. The setup error and interfractional …

Phase I/II clinical trial of nivolumab in combination with oligo-fractionated irradiation for unresectable advanced or recurrent gastric cancer Open

Kosaku Mimura, Takashi Ogata, Yuya Yoshimoto, Daisaku Yoshida, Shotaro Nakajima , et al. · 2023

Safety of Carbon-ion Radiotherapy for Prostate Cancer After Rectal Cancer Surgery Open

Yosuke Takakusagi, Hiroaki Koge, Kio Kano, Satoshi Shima, KEISUKE TSUCHIDA , et al. · 2023

Late gastrointestinal toxicity was tolerable in patients with prostate cancer treated with CIRT after rectal cancer surgery. Patients with both a PTV adjacent rectal anastomosis and diabetes mellitus were more likely to experience late gas…

Clinical Outcomes of Intensity-modulated Carbon-ion Radiotherapy for Bone and Soft Tissue Tumors Open

Yosuke Takakusagi, Hiroaki Koge, Kio Kano, Satoshi Shima, KEISUKE TSUCHIDA , et al. · 2023

IMCT for BSTs showed good local therapeutic efficacy and tolerable toxicity in patients with bone and soft tissue tumors.

Clinical results of carbon-ion radiotherapy for stage I non-small cell lung cancer with concomitant interstitial lung disease: a Japanese national registry study (J-CROS-LUNG) Open

Naoko Okano, Hiroaki Suefuji, Mio Nakajima, Sunao Tokumaru, Nobuteru Kubo , et al. · 2023

Anti-cancer treatments for lung cancer patients with interstitial lung disease (ILD) are challenging. The treatment options for ILD are often limited because of concerns that treatments can cause acute exacerbation (AE) of ILD. This study …

Clinical results of carbon ion radiotherapy for inoperable stage I non-small cell lung cancer: A Japanese national registry study (J-CROS-LUNG) Open

Nobuteru Kubo, Hiroaki Suefuji, Mio Nakajima, Sunao Tokumaru, Naoko Okano , et al. · 2023

This study provides real-world treatment outcomes of CIRT for inoperable. stage I NSCLC in Japan.

Carbon-ion Radiotherapy for Inoperable Solitary Fibrous Tumor of the Skull Base: A Case Report Open

Shintaro Shiba, Yosuke Takakusagi, Nobutaka Mizoguchi, Keisuke Tsuchida, Satoshi Shima , et al. · 2023

These findings suggest that C-ion RT is a suitable treatment option for inoperable SFTs of the skull base.

Carbon-Ion Radiotherapy Using Metal Artifact Reduction Computed Tomography in a Patient with Prostate Cancer with Bilateral Hip Prostheses: A Case Report Open

Yosuke Takakusagi, Yoshiki Takayama, Yohsuke Kusano, Hiroaki Koge, Kio Kano , et al. · 2022

Carbon-ion radiotherapy (CIRT) for prostate cancer is both safe and efficacious; beam range calculations use relative stopping power ratio, which is derived from computed tomography (CT) values. However, hip prostheses are made of high ato…

Robust treatment planning in scanned carbon-ion radiotherapy for pancreatic cancer: Clinical verification using in-room computed tomography images Open

Yohsuke Kusano, Hiroyuki Katoh, Shinichi Minohara, Hajime Fujii, Yuya Miyasaka , et al. · 2022

Purpose Carbon-ion beam (C-beam) has a sharp dose distribution called the Bragg peak. Carbon-ion radiation therapy, such as stereotactic body radiotherapy in photon radiotherapy, can be completed in a short period by concentrating the radi…

Clinical Outcomes of Scanning Carbon-ion Radiotherapy for Soft Tissue Sarcoma of the Extremities Open

Yosuke Takakusagi, Itsuko Serizawa, Hiroaki Koge, Kio Kano, Satoshi Shima , et al. · 2022

sCIRT for STS of the extremities demonstrates favorable therapeutic results with acceptable toxicity.

Correction to: Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer Open

Yosuke Takakusagi, Hiroyuki Katoh, Kio Kano, Wataru Anno, Keisuke Tsuchida , et al. · 2022

Clinical Outcomes of Radiotherapy in Elderly and Younger Patients With T4 Esophageal Cancer: A Retrospective Single-center Analysis Open

Yosuke Takakusagi, Kio Kano, Satoshi Shima, Keisuke Tsuchida, Nobutaka Mizoguchi , et al. · 2022

The clinical outcomes of RT for T4 esophageal cancer in elderly patients were generally similar to those in the younger group.

Evaluation of Safety for Scanning Carbon-Ion Radiotherapy in Hemodialysis Patients With Prostate Cancer Open

Yosuke Takakusagi, Makito Suga, Yohsuke Kusano, Kio Kano, Satoshi Shima , et al. · 2022

Three cases of retroperitoneal sarcoma in which bioabsorbable spacers (bioabsorbable polyglycolic acid spacers) were inserted prior to carbon ion radiotherapy Open

Itsuko Serizawa, Yohsuke Kusano, Kio Kano, Satoshi Shima, Keisuke Tsuchida , et al. · 2022

From August 2019 to August 2020, we inserted polyglycolic acid (PGA) spacers and administered carbon ion radiotherapy (CIRT) to three cases of retroperitoneal sarcoma at our hospital. We aimed to investigate its utility and safety for retr…

Evaluation of Safety for Scanning Carbon-Ion Radiotherapy in Hemodialysis Patients with Prostate Cancer Open

Yosuke Takakusagi, Makito Suga, Yohsuke Kusano, Kio Kano, Satoshi Shima , et al. · 2021

Background/Aim The efficacy and safety of carbon-ion radiotherapy (CIRT) for prostate cancer have already been demonstrated. The number of hemodialysis (HD) patients is increasing. Although the toxicity of CIRT in HD patients may be more s…

Radiation recall pneumonitis after <span>COVID</span>‐19 vaccination Open

Kanako Shinada, Shuji Murakami, Daisaku Yoshida, Haruhiro Saito · 2021

A 48-year-old male was diagnosed with locally advanced, unresectable, non-small-cell lung cancer (Figure 1a). He received chemoradiotherapy concurrently with a regimen of cisplatin and docetaxel, and intensity-modulated radiotherapy (60 Gy…

Comparison of Clinical Outcomes of Definitive and Postoperative Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck: Can Definitive Radiotherapy Be a Treatment Option? Open

Nobutaka Mizoguchi, Kio Kano, Satoshi Shima, Keisuke Tsuchida, Yosuke Takakusagi , et al. · 2021

Background: The standard treatment for adenoid cystic carcinoma of the head and neck is surgical resection followed by postoperative radiotherapy (PORT). Currently, definitive radiotherapy (defRT) is considered an inadequate treatment; how…

P8‐69: Clinical study of chemotherapy with an immune checkpoint inhibitor combination chemotherapy in advanced small cell lung cancer Open

Seigo Katakura, Shuji Murakami, Daisaku Yoshida, Kanako Shinada, Ryota Ushio , et al. · 2021

occurred in 23patients, including two cases of pneumonitis.No grade 3 or higher adverse event was observed.Conclusion: Atezolizumab showed promising anti-tumor activity regardless of PD-L1 expression status with a manageable safety profile…

P8‐67: A retrospective study of recurrence patterns in chemoradiotherapy using volumetric modulated arc therapy for locally advanced non‐small cell lung cancer Open

Seigo Katakura, Shuji Murakami, Daisaku Yoshida, Kanako Shinada, Ryota Ushio , et al. · 2021

occurred in 23patients, including two cases of pneumonitis.No grade 3 or higher adverse event was observed.Conclusion: Atezolizumab showed promising anti-tumor activity regardless of PD-L1 expression status with a manageable safety profile…

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