Daisuke Ihara
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Neuronal Plasticity-related Mechanisms Triggered by the Transcriptional Coactivator MRTFB, a Regulator for Neuronal Morphology and Gene Expression Open
Synaptic plasticity is a key mechanism underlying long-term memory and learning, with proposed associations with altered actin cytoskeleton and gene expression in neurons. Myocardin-related transcription factor (MRTF) family members, abund…
Expression of <i>c-fos</i> in cortical neuron cultures under dynamic magnetic field is not suppressed by calcium channel blockers Open
Previously, we developed a dynamic magnetic field (DMF) device using neodymium magnets that induced c-fos expression in cortical neurons, while activity-regulated cytoskeleton-associated protein (Arc), and brain-derived neurotrophic factor…
Panax notoginseng root extract induces nuclear translocation of CRTC1 and <i>Bdnf</i> mRNA expression in cortical neurons Open
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is deeply involved in the development and higher function of the nervous system, including learning and memory. By contrast, a reduction in BDNF levels is assoc…
The BDNF-ERK/MAPK axis reduces <i>phosphatase and actin regulator1</i>, <i>2</i> and <i>3</i> (<i>PHACTR1</i>, <i>2</i> and <i>3</i>) mRNA expressions in cortical neurons Open
Actin rearrangement and phosphorylation-dephosphorylation in the nervous system contribute to plastic alteration of neuronal structure and function. Phosphatase and actin regulator (PHACTR) family members are actin- and protein phosphatase…
Enhancing <i>c‐fos</i><span>mRNA</span> Expression in Primary Cortical Cell Cultures with a Dynamic Magnetic Fields Device Open
Magnetic fields have the potential to impact biological systems and trigger various biological responses. However, the mechanisms underlying dynamic magnetic fields (DMFs), which are created by rotating magnets based on Arago's disk princi…
Endogenous SOLOIST/MRTFB i4, a Neuronal Isoform of MKL2/MRTFB, Positively and Negatively Regulates SRF Target Immediate Early Genes in Neuro-2a Cells Open
Megakaryoblastic leukemia 2 (MKL2)/myocardin-related transcription factor-B (MRTFB) is a serum response factor (SRF) cofactor that is enriched in the brain and controls SRF target genes and neuronal morphology. There are at least four isof…
SRF and SRF Cofactor mRNA Expression Is Differentially Regulated by BDNF Stimulation in Cortical Neurons Open
Serum response factor (SRF) is a transcription factor that plays essential roles in multiple brain functions in concert with SRF cofactors such as ternary complex factor (TCF) and megakaryoblastic leukemia (MKL)/myocardin-related transcrip…
Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF Open
Accumulating evidence suggests that the serum response factor (SRF) cofactor megakaryoblastic leukemia (MKL)/myocardin-related transcription factor (MRTF) has critical roles in many physiological and pathological processes in various cell …
Investigation of the Excitation Wavelength for Extension of Diagnostic Depth in 5-aminolevulinic Acid-based Photodynamic Diagnosis of Bladder Cancer Open
膀胱癌に対するアミノレブリン酸光線力学診断（5-aminolevulinic acid-based photodynamic diagnosis: ALA-PDD）における診断深度の励起光波長の選択による拡張を検証した．膀胱組織中の光減衰とプロトポルフィリンIXの光吸収特性に基づく理論計算で，腫瘍の深さが0.9 mm以深では波長505 nmの緑色光励起で蛍光強度が最も高くなった．摘出ブタ膀胱組織を用いた実験で，現行ALA-PDDシステムで用いられている波長405 nmと波長…
Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin‐related transcription factor‐B, negatively regulates dendritic complexity in cortical neurons Open
Megakaryoblastic leukemia 2 (MKL2)/myocardin‐related transcription factor‐B (MRTFB), a serum response factor (SRF) coactivator, is an important regulator of gene expression and neuronal morphology. Here, we show that different mouse MRTFB …
Fluorescence detection of deep intramucosal cancer excited by green light for photodynamic diagnosis using protoporphyrin IX induced by 5-aminolevulinic acid: an ex vivo study Open
The experimental results suggest that the diagnosis depth of PDD with PpIX for intramucosal cancer can be extended by 505-nm excitation light.
Acetylcholine receptor antibody-positive myasthenia gravis associated with small-cell lung cancer Open
AChR-ab-positive MG may develop as a comorbidity of SCLC. In such cases, management might require treatment for SCLC in addition to the standard MG treatment to stabilize the MG symptoms.
Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology Open
The megakaryoblastic leukaemia (MKL) family are serum response factor (SRF) coactivators, which are highly expressed in the brain. Accordingly, MKL plays important roles in dendritic morphology, neuronal migration, and brain development. F…
Deltamethrin Increases Neurite Outgrowth in Cortical Neurons through Endogenous BDNF/TrkB Pathways Open
Deltamethrin (DM), a type II pyrethroid, robustly increases brain-derived neurotrophic factor (Bdnf) expression and has a neurotrophic effect in primary cultures of rat cortical neurons. In this study, we investigated the effect of DM on n…