Daisuke Inukai
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View article: A case of malignant transformation to angiosarcoma during long-term follow-up of a cervical schwannoma
A case of malignant transformation to angiosarcoma during long-term follow-up of a cervical schwannoma Open
神経鞘腫が血管肉腫に悪性転化した1例を報告する。症例は46歳の男性,左頸部腫瘍の増大と頭痛のため当院を受診した。CT画像では,左胸鎖乳突筋の深部に長径約80mmの腫瘤性病変を認め,境界は明瞭で辺縁の造影効果が強いが,内部は出血や壊死の可能性を示す広範な低吸収領域を認めた。細胞診では悪性細胞が検出されたが,病理確定診断には至らなかった。診断と治療の目的で腫瘍切除を施行したところ,神経鞘腫と血管肉腫が併存しており,神経鞘腫が悪性転化した血管肉腫と診断された。手術後,早期再発腫瘍…
View article: Immune Status of Cervical Lymph Nodes in Head and Neck Cancer—A Surgical Oncology Perspective
Immune Status of Cervical Lymph Nodes in Head and Neck Cancer—A Surgical Oncology Perspective Open
Neck dissection for cervical lymph node metastasis is an established procedure for head and neck cancer (HNC). However, with the advent of immunotherapy, head and neck surgical oncologists need to rethink removing all lymph nodes, includin…
View article: Artesunate and cisplatin synergistically inhibit HNSCC cell growth and promote apoptosis with artesunate‑induced decreases in Rb and phosphorylated Rb levels
Artesunate and cisplatin synergistically inhibit HNSCC cell growth and promote apoptosis with artesunate‑induced decreases in Rb and phosphorylated Rb levels Open
In the treatment of head and neck cancer, cisplatin is often used as a therapeutic agent; however, its efficacy is limited and it can cause renal dysfunction as an adverse effect. For this reason, the use of cisplatin is limited in elderly…
View article: Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease
Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease Open
In 15–20% of cases, Graves’ disease (GD) shifts to Hashimoto’s thyroiditis (HT), while the shift from HT to GD is rare. We present a case of a patient in whom HT shifted to GD, along with a literature review. A 50-year-old woman with myxed…
View article: A Novel Treatment Strategy for Advanced Lacrimal Sac Carcinomas Confirmed by p16 Immunostaining
A Novel Treatment Strategy for Advanced Lacrimal Sac Carcinomas Confirmed by p16 Immunostaining Open
This article aims to describe the two cases in which chemotherapy and chemoradiotherapy were effective for advanced HPV-related lacrimal sac squamous cell carcinoma and avoided the need for radical surgery. This was an interventional study…
View article: Thyroid Gland Flap for Minimally Invasive Reconstructive Head and Neck Surgery
Thyroid Gland Flap for Minimally Invasive Reconstructive Head and Neck Surgery Open
Background: Head and neck surgery sometimes causes small defects, and salvage surgery after chemoradiotherapy poses some risk because of damage to the surgical site from the previous treatment. We have developed a novel thyroid gland flap …
View article: Pathological and Virological Studies of p16-Positive Oropharyngeal Carcinoma with a Good Response to Neoadjuvant Chemotherapy
Pathological and Virological Studies of p16-Positive Oropharyngeal Carcinoma with a Good Response to Neoadjuvant Chemotherapy Open
Human papillomavirus (HPV)-related, p16-positive oropharyngeal carcinoma is considered to be sensitive to anticancer drugs, and the standard treatment is therefore chemoradiotherapy, rather than surgery, especially for aggressive disease. …
View article: Identification of cisplatin-resistant factor by integration of transcriptomic and proteomic data using head and neck carcinoma cell lines.
Identification of cisplatin-resistant factor by integration of transcriptomic and proteomic data using head and neck carcinoma cell lines. Open
Cisplatin is an important drug for the treatment of head and neck squamous cell carcinoma (HNSCC). Determining chemoresistant factors prior to treatment will lead to great benefits for clinicians and patients. Here, we evaluated chemoresis…
View article: Painless thyroiditis in a dupilumab-treated patient
Painless thyroiditis in a dupilumab-treated patient Open
Summary Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hy…
View article: Incisionless facial resection for Kadish stage C olfactory neuroblastoma: Transcaruncular approach with combined endonasal and skull base surgery
Incisionless facial resection for Kadish stage C olfactory neuroblastoma: Transcaruncular approach with combined endonasal and skull base surgery Open
This case report describes resection without facial incision for aggressive Kadish stage C olfactory neuroblastoma (ONB). We performed resection via transcaruncular approach with combined endonasal and skull base surgery. This multidiscipl…
View article: Distribution of descending necrotizing mediastinitis and efficacy of distribution-specific drainage
Distribution of descending necrotizing mediastinitis and efficacy of distribution-specific drainage Open
We were able to cure all seven patients with DNM. It might be helpful to recognize the exact distribution of the abscess and distribution-specific drainage using a new map and classification of thoracic abscess.
View article: Immune‐checkpoint molecules on regulatory T‐cells as a potential therapeutic target in head and neck squamous cell cancers
Immune‐checkpoint molecules on regulatory T‐cells as a potential therapeutic target in head and neck squamous cell cancers Open
Immune‐checkpoint inhibitors improve the survival of head and neck squamous cell carcinoma (HNSCC) patients. Although recent studies have demonstrated that the tumor immune microenvironment (TIME) has critical roles in immunotherapy, the p…
View article: Inside Front Cover
Inside Front Cover Open
The cover image is based on the Case Report A novel larynx‐preserving pharyngectomy technique using a thyroid gland flap after chemoradiotherapy by Tetsuya Ogawa, Nobuyuki Katahira, Taichi Kan et al., https://doi.org/10.1002/ccr3.2477 [Ima…
View article: A novel larynx‐preserving pharyngectomy technique using a thyroid gland flap after chemoradiotherapy
A novel larynx‐preserving pharyngectomy technique using a thyroid gland flap after chemoradiotherapy Open
This case report describes larynx‐preserving pharyngectomy after chemoradiotherapy using a thyroid gland flap. A thyroid gland flap has good blood supply and reconstruction can be done in the same surgical field. The thyroid gland flap has…
View article: Adult retropharyngeal abscess
Adult retropharyngeal abscess Open
A 60-year-old man was referred to our hospital after complaining of throat pain for several days.He described the condition as a cold with sore throat.A physical examination revealed swelling of the posterior wall of the oropharynx.Sagitta…