Explanipedia

Correction to: Computer model of IL-6-dependent rheumatoid arthritis in F759 mice Open

Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto , et al. · 2024

The association of inflammation and chronic kidney disease with incident heart failure: a pooled cohort analysis Open

A Hamid, Ahmed Minhas, M Tio, MS Khan, MS Usman , et al. · 2024

Dengue virus infection induces selective expansion of Vγ4 and Vγ6TCR γδ T cells in the small intestine and a cytokine storm driving vascular leakage in mice Open

Takeshi Kurosu, Daisuke Okuzaki, Yusuke Sakai, Mohamad Al Kadi, Supranee Phanthanawiboon , et al. · 2023

Dengue is a major health problem in tropical and subtropical regions. Some patients develop a severe form of dengue, called dengue hemorrhagic fever, which can be fatal. Severe dengue is associated with a transient increase in vascular per…

Resting heart rate as a possible biomarker and target to prevent future cardiovascular disease in type 2 diabetes patients (HTR-2023-0066.R2) Open

Daisuke Kamimura, Kouichi Tamura · 2023

Interleukin-17A released from intestinal γδT cells induces cytokine storm in mice with severe dengue Open

Takeshi Kurosu, Daisuke Okuzaki, Yusuke Sakai, Mohamad Al Kadi, Supranee Phanthanawiboon , et al. · 2022

Blockade of TNF-α signaling protects mice from lethal infection with dengue virus (DENV); however, what causes cytokine storm or how TNF-α aggravates the disease remains unknown. Here, we performed transcriptome analysis of the liver and s…

ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons Open

Rie Hasebe, Kaoru Murakami, Masaya Harada, Nada Halaka, Hiroshi Nakagawa , et al. · 2022

Neural circuits between lesions are one mechanism through which local inflammation spreads to remote positions. Here, we show the inflammatory signal on one side of the joint is spread to the other side via sensory neuron–interneuron cross…

Rhodobacter azotoformans LPS (RAP99-LPS) Is a TLR4 Agonist That Inhibits Lung Metastasis and Enhances TLR3-Mediated Chemokine Expression Open

Kaoru Murakami, Daisuke Kamimura, Rie Hasebe, M. Uchida, Nobuya Abe , et al. · 2021

The lipopolysaccharides (LPSs) of Rhodobacter are reported to be TLR4 antagonists. Accordingly, the extract of Rhodobacter azotoformans (RAP99) is used as a health supplement for humans and animals in Japan to regulate immune responses in …

Sjögren’s syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development Open

Shuhei Shimoyama, Ikuma Nakagawa, Jing‐Jing Jiang, Isao Matsumoto, John A. Chiorini , et al. · 2021

Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation with lymphoid infiltration and destruction of the salivary glands. Although many genome-wide association studies have revealed disease-associated risk alleles, …

Corrigendum: Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation Open

Haruka Higuchi, Daisuke Kamimura, Jing‐Jing Jiang, Toru Atsumi, Daiki Iwami , et al. · 2020

Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation Open

Haruka Higuchi, Daisuke Kamimura, Jing‐Jing Jiang, Toru Atsumi, Daiki Iwami , et al. · 2020

Chronic allograft rejection is the most common cause of long-term allograft failure. One reason is that current diagnostics and therapeutics for chronic allograft rejection are very limited. We here show that enhanced NFκB signaling in kid…

Flavin-Adenine Dinucleotide Induced by Antigravity Responses in the Spinal Cord Suppresses EAE Development Open

Kumiko Tanaka, Madoka Higuchi, Yasunobu Arima, Jing‐Jing Jiang, Nobuo Shinohara , et al. · 2020

Bidirectional communication between neural and immune systems Open

Daisuke Kamimura, Yuki Tanaka, Rie Hasebe, Masaaki Murakami · 2019

The immune and nervous systems share many features, including receptor and ligand expression, enabling efficient communication between the two. Accumulating evidence suggests that the communication is bidirectional, with the neural system …

Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response Open

Hiroki Tanaka, Yasunobu Arima, Daisuke Kamimura, Yuki Tanaka, Noriyuki Takahashi , et al. · 2019

Regnase-1 (also known as Zc3h12a or MCPIP-1) is an endoribonuclease involved in mRNA degradation of inflammation-associated genes. Regnase-1 is inactivated in response to external stimuli through post-translational modifications including …

Neural stimulations regulate the infiltration of immune cells into the <span>CNS</span> Open

Daisuke Kamimura, Masaaki Murakami · 2019

The systemic regulation of immune reactions by the nervous system is well studied and depends on the release of hormones. Some regional regulations of immune reactions, on the other hand, depend on specific neural pathways. Better understa…

Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines Open

Masaaki Murakami, Daisuke Kamimura, Toshio Hirano · 2019

Photopic light-mediated down-regulation of local α1A-adrenergic signaling protects blood-retina barrier in experimental autoimmune uveoretinitis Open

Andrea Štofková, Daisuke Kamimura, Takuto Ohki, Mitsutoshi Ota, Yasunobu Arima , et al. · 2019

Gateway Reflex: A Neuro-Immune Crosstalk for Organ-Specific Disease Development Open

Daisuke Kamimura, Yuki Tanaka, Takuto Ohki, Masaaki Murakami · 2019

Homeostasis of the central nervous system (CNS) is strictly regulated by a unique structure of blood vessels, the blood-brain barrier (BBB). Experimental and clinical evidence has revealed that abnormalities in the BBB in chronic inflammat…

Gateway reflex: Local neuroimmune interactions that regulate blood vessels Open

Daisuke Kamimura, Takuto Ohki, Yasunobu Arima, Mitsutoshi Ota, Masaaki Murakami · 2018

NEDD4 Is Involved in Inflammation Development during Keloid Formation Open

Munezumi Fujita, Yuhei Yamamoto, Jing‐Jing Jiang, Toru Atsumi, Yuki Tanaka , et al. · 2018

Gateway reflex: neural activation-mediated immune cell gateways in the central nervous system Open

Daisuke Kamimura, Takuto Ohki, Yasunobu Arima, Masaaki Murakami · 2018

The neural regulation of organs can be categorized as systemic or local. Whereas systemic regulation by the hypothalamus–pituitary–adrenal gland-mediated release of steroid hormones has been well studied, the mechanisms for local regulatio…

Cigarette Smoking and Incident Heart Failure Open

Daisuke Kamimura, Loretta Cain, Robert J. Mentz, Wendy White, Michael J. Blaha , et al. · 2018

Background: Cigarette smoking has been linked with several factors associated with cardiac dysfunction. We hypothesized that cigarette smoking is associated with left ventricular (LV) structure and function, and incident heart failure (HF)…

Existence of NEU1 sialidase on mouse thymocytes whose natural substrate is CD5 Open

Shigeko Kijimoto‐Ochiai, Tokuko Matsumoto-Mizuno, Daisuke Kamimura, Masaaki Murakami, Miwako Kobayashi , et al. · 2018

Membrane-bound sialidases in the mouse thymus are unique and mysterious because their activity at pH 6.5 is equal to or higher than that in the acidic region. The pH curve like this has never been reported in membrane-bound form. To clarif…

The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels Open

Yuki Tanaka, Yasunobu Arima, Daisuke Kamimura, Masaaki Murakami · 2017

The gateway reflex is a new phenomenon that explains how immune cells bypass the blood-brain barrier to infiltrate the central nervous system (CNS) and trigger neuroinflammation. To date, four examples of gateway reflexes have been discove…

Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit Open

Yasunobu Arima, Takuto Ohki, Naoki Nishikawa, Kotaro Higuchi, Mitsutoshi Ota , et al. · 2017

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress conditions, EAE caused severe gastrointestin…

Targeting molecules involved in immune cell trafficking to the central nervous system for therapy in multiple sclerosis Open

Mohamed Elfeky, Daisuke Kamimura, Yasunobu Arima, Masaaki Murakami, Lawrence Steinman · 2017

The entry of immune cells into the central nervous system ( CNS ) for immune surveillance occurs during normal physiological conditions, although it is difficult to detect. However, during CNS autoimmune diseases, such as multiple sclerosi…

Author response: Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit Open

Yasunobu Arima, Takuto Ohki, Naoki Nishikawa, Kotaro Higuchi, Mitsutoshi Ota , et al. · 2017

Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Impact of stress on diseases including gastrointestinal fail…

Gateway reflexes: A new paradigm of neuroimmune interactions Open

Takuto Ohki, Daisuke Kamimura, Yasunobu Arima, Masaaki Murakami · 2017

The immune system is affected considerably by the physical environment. The molecular mechanisms that regulate this connection are not well understood. Because neural activities sense the environment, it has been hypothesized that neural s…

EAE Induction by Passive Transfer of MOG-specific CD4+ T Cells Open

Yuki Tanaka, Yasunobu Arima, Kotaro Higuchi, Takuto Ohki, Mohamed Elfeky , et al. · 2017

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), which is a chronic inflammatory disease of the central nervous system (CNS). It is characterized by focal demyelination and inflammatory respons…

The Gateway Reflex, a Novel Neuro‐immune Interaction, is Critical for the Development of Mouse Multiple Sclerosis (MS) Models Open

Daisuke Kamimura, Yasunobu Arima, Andrea Štofková, Naoki Nishikawa, Kotaro Higuchi , et al. · 2016

The central nervous system (CNS) is an immune‐privileged tissue protected by the brain–blood barrier (BBB), which limits the absorption of substances and cells from blood flow. In the case of inflammatory diseases in the CNS, such as multi…

Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling Open

Daisuke Kamimura, Toru Atsumi, Andrea Štofková, Naoki Nishikawa, Takuto Ohki , et al. · 2015

The survival of naïve T cells is believed to require signals from TCR-pMHC interactions and cytokines such as IL-7. In contrast, signals that negatively impact naïve T cell survival are less understood. We conducted a forward genetic scree…

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