Daisuke Kawauchi
YOU?
Author Swipe
View article: Figure S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Figure S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Supplementary Figure 1: T cell responses in A2.DR1 and DR4 mice after peptide vaccination with potential shared neoepitopes. A. Predicted binding affinity for selected amino acid alterations for HLA-A*0201 determined by NetMHC 4.0. B, C. Q…
View article: Table S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Table S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Table S3. Primer for single cell T cell receptor sequencing.
View article: PATH-22. Characteristics of various comprehensive genomic profiling tests for central nervous system tumors in Japan since 2023
PATH-22. Characteristics of various comprehensive genomic profiling tests for central nervous system tumors in Japan since 2023 Open
BACKGROUND In Japan, two cancer gene panel (CGP) tests—OncoGuide™ NCC Oncopanel System (NCCG) and FoundationOne® CDx (F1)—were first covered by public insurance in June 2019 and are widely used to identify actionable genetic alterations in…
View article: Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion
Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion Open
To move forward, cells must exert backward forces against their surrounding environment. Recent studies have highlighted the importance of integrin‐independent forces for cell migration; however, the molecular machinery that exerts forces …
View article: Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors
Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors Open
Circular extrachromosomal DNA (ecDNA) is a common form of oncogene amplification in aggressive cancers. The frequency and diversity of ecDNA has been catalogued in adult and some childhood cancers; however, its role in most pediatric cance…
View article: Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression
Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression Open
Medulloblastoma (MB), a common malignant pediatric brain tumor arising in the cerebellum, is characterized by mutations in chromatin modifiers, highlighting the significance of chromatin modification abnormalities in its progression. While…
View article: Author Correction: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage
Author Correction: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage Open
View article: Risk Factors of Distant Recurrence and Dissemination of IDH Wild-Type Glioblastoma: A Single-Center Study and Meta-Analysis
Risk Factors of Distant Recurrence and Dissemination of IDH Wild-Type Glioblastoma: A Single-Center Study and Meta-Analysis Open
Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) is a highly aggressive brain tumor with a high recurrence rate despite adjuvant treatment. This study aimed to evaluate the risk factors for non-local recurrence of GBM. In the pr…
View article: AB023. Early diagnosis and treatment lead to improve survival of glioblastoma patients
AB023. Early diagnosis and treatment lead to improve survival of glioblastoma patients Open
Early diagnosis and surgery within 3 weeks from the initial symptoms are associated with improved patient survival. Early GBM treatment will be beneficial for patients with GBM. A short duration from the first hospital visit to the first s…
View article: METB-03. SOLID PEDIATRIC TUMORS IN MICE REVEAL MODEL-SPECIFIC GLOBAL DNA METHYLATION AND CNV PROFILES CORRESPONDING TO HUMAN COUNTERPARTS
METB-03. SOLID PEDIATRIC TUMORS IN MICE REVEAL MODEL-SPECIFIC GLOBAL DNA METHYLATION AND CNV PROFILES CORRESPONDING TO HUMAN COUNTERPARTS Open
BACKGROUND The analysis and comparison of global DNA methylation patterns has become a gold standard in modern neuropathology. For human central nervous system (CNS) tumors and other cancers, the research community has collected thousands …
View article: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage
Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage Open
Medulloblastomas with extensive nodularity are cerebellar tumors characterized by two distinct compartments and variable disease progression. The mechanisms governing the balance between proliferation and differentiation in MBEN remain poo…
View article: Mapping pediatric brain tumors to their origins in the developing cerebellum
Mapping pediatric brain tumors to their origins in the developing cerebellum Open
Background Distinguishing the cellular origins of childhood brain tumors is key for understanding tumor initiation and identifying lineage-restricted, tumor-specific therapeutic targets. Previous strategies to map the cell-of-origin typica…
View article: Data from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Data from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Purpose:Gliomas are intrinsic brain tumors with a high degree of constitutive and acquired resistance to standard therapeutic modalities such as radiotherapy and alkylating chemotherapy. Glioma subtypes are recognized by characteristic mut…
View article: Table S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Table S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Table S1A. Peptides; Table S1B. NetMHCIIpan 4.0; Table S1C. NetMHC 4.0
View article: Figure S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Figure S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Supplementary Figure 1: T cell responses in A2.DR1 and DR4 mice after peptide vaccination with potential shared neoepitopes. A. Predicted binding affinity for selected amino acid alterations for HLA-A*0201 determined by NetMHC 4.0. B, C. Q…
View article: Table S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Table S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Table S1A. Peptides; Table S1B. NetMHCIIpan 4.0; Table S1C. NetMHC 4.0
View article: Table S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Table S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Table S2. Murine primers for evaluation of Cic expression.
View article: Figure S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Figure S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Supplementary Figure 3: T cell effector functions of TCR-transgenic T cells targeting CICR215W. A. Venn diagram of shared TCR-β sequences in T cell lines generated from n = 4 CICR215W vaccinated mice. B. Normalized IFN-γ production of di…
View article: Table S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Table S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Table S3. Primer for single cell T cell receptor sequencing.
View article: Figure S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Figure S1 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Supplementary Figure 1: T cell responses in A2.DR1 and DR4 mice after peptide vaccination with potential shared neoepitopes. A. Predicted binding affinity for selected amino acid alterations for HLA-A*0201 determined by NetMHC 4.0. B, C. Q…
View article: Figure S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Figure S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Supplementary Figure 2: Molecular features of A2.DR1 MHC-humanized gliomas. A. Verification of the CRISPR-Cas9-mediated functional KO of p53 and Nf1 in the A2.DR1 glioma cell line. B. Copy number variations (CNVs) in the A2.DR1 glioma cell…
View article: Figure S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Figure S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Supplementary Figure 2: Molecular features of A2.DR1 MHC-humanized gliomas. A. Verification of the CRISPR-Cas9-mediated functional KO of p53 and Nf1 in the A2.DR1 glioma cell line. B. Copy number variations (CNVs) in the A2.DR1 glioma cell…
View article: Table S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Table S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Table S3. Primer for single cell T cell receptor sequencing.
View article: Data from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Data from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Purpose:Gliomas are intrinsic brain tumors with a high degree of constitutive and acquired resistance to standard therapeutic modalities such as radiotherapy and alkylating chemotherapy. Glioma subtypes are recognized by characteristic mut…
View article: Figure S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Figure S3 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Supplementary Figure 3: T cell effector functions of TCR-transgenic T cells targeting CICR215W. A. Venn diagram of shared TCR-β sequences in T cell lines generated from n = 4 CICR215W vaccinated mice. B. Normalized IFN-γ production of di…
View article: Table S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Table S2 from T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas Open
Table S2. Murine primers for evaluation of Cic expression.
View article: Figure S2 from ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
Figure S2 from ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma Open
Figure S2 supporting expression and localization of ZRfus in the mouse IUE model.
View article: Supplementary Table S5 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas
Supplementary Table S5 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas Open
Suppl. Table S5 - GO analysis for C11orf95-target models specific DEGs
View article: Figure S4 from <i>ZFTA</i> Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors
Figure S4 from <i>ZFTA</i> Translocations Constitute Ependymoma Chromatin Remodeling and Transcription Factors Open
ZFTA-RELAFUS1 chromatin binding and remodelling
View article: Table S6 from ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
Table S6 from ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma Open
DNA motifs detected and shared with mouse embryonic fibroblasts treated with TNF-alpha