Daisuke Tokuhara
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View article: Safety and efficacy of prednisolone, mizoribine and lisinopril combination therapy for severe childhood IgA Nephropathy
Safety and efficacy of prednisolone, mizoribine and lisinopril combination therapy for severe childhood IgA Nephropathy Open
Background Angiotensin-converting enzyme inhibitors such as lisinopril have long been used for childhood IgA Nephropathy (cIgAN). A two-year combined regimen including prednisolone + mizoribine + warfarin + dipyridamole was shown in our pr…
View article: Effect of Coil Type on the Number of Coils Used and the Procedure Time for Pre-Fontan Coil Embolization of Collateral Arteries
Effect of Coil Type on the Number of Coils Used and the Procedure Time for Pre-Fontan Coil Embolization of Collateral Arteries Open
In pre-Fontan coil embolization, a combination of longer microcoils (≥30 cm) may help reduce the number of coils used and the procedure time, which may decrease the health care cost and radiation exposure.
View article: Efficacy and Safety of Glecaprevir/Pibrentasvir in Children Aged 3–11 Years With Chronic Hepatitis C: A Real‐World, Prospective, Multicenter Study in Japan
Efficacy and Safety of Glecaprevir/Pibrentasvir in Children Aged 3–11 Years With Chronic Hepatitis C: A Real‐World, Prospective, Multicenter Study in Japan Open
Aim Part 2 of the DORA study, an international clinical trial evaluating glecaprevir and pibrentasvir (G/P) treatment in children aged 3–11 years with chronic hepatitis C virus (HCV) infection, demonstrated high efficacy and safety. Howeve…
View article: Predictive risk factors for meconium-related ileus requiring surgical intervention in very low birth weight infants
Predictive risk factors for meconium-related ileus requiring surgical intervention in very low birth weight infants Open
VLBWI with an MRI index ≥0.205 have a significantly high risk of requiring surgery.
View article: Trough value prediction using umbilical blood cystatin C value during tobramycin administration
Trough value prediction using umbilical blood cystatin C value during tobramycin administration Open
Background Therapeutic monitoring is recommended for aminoglycoside drugs, which are often used in neonatal care. In this study, we examined whether it is possible to estimate the trough value after administration using serum creatinine (C…
View article: Evaluation of diagnostic criteria for mild‐to‐advanced stages of Fontan‐associated liver disease: A nationwide epidemiological survey in Japan
Evaluation of diagnostic criteria for mild‐to‐advanced stages of Fontan‐associated liver disease: A nationwide epidemiological survey in Japan Open
Aim Fontan‐associated liver disease (FALD) is a complication after Fontan surgery, and a common cause of liver tumors and cirrhosis. However, no diagnostic criteria for FALD have been established, leading to an underestimation of its preva…
View article: Fontan-associated liver disease: the importance of multidisciplinary teamwork in its management
Fontan-associated liver disease: the importance of multidisciplinary teamwork in its management Open
The Fontan operation, which directly connects the superior and inferior vena cava to the pulmonary artery, is a palliative surgery for children with a functional or anatomic single ventricle. This procedure leads to hemodynamic changes (Fo…
View article: Analysis of infantile hemangioma without proliferation after birth
Analysis of infantile hemangioma without proliferation after birth Open
Infantile hemangiomas (IHs) are the most common benign tumors of infancy, occurring in approximately 5-10% of the population. Among what appear to be typical IHs with proliferative and involuting phases, we noticed that there are also IHs …
View article: Successful retrieval of a foreign body in an infant's right pulmonary artery using the new boomerang loop–snare technique: A case report
Successful retrieval of a foreign body in an infant's right pulmonary artery using the new boomerang loop–snare technique: A case report Open
We report successful percutaneous retrieval of a foreign body located in an infant's right pulmonary artery using the new boomerang loop-snare technique. The case was an 18-month-old girl. A central venous catheter for chemotherapy was ins…
View article: Case report: Cochlear implantation was effective for progressive bilateral severe hearing loss associated with Kawasaki disease
Case report: Cochlear implantation was effective for progressive bilateral severe hearing loss associated with Kawasaki disease Open
Sensorineural hearing loss associated with Kawasaki disease has been increasingly reported, but its etiology remains unclear. Most reported cases of sensorineural hearing loss associated with Kawasaki disease have been mild and reversible …
View article: Case Report: Ciclosporin A for Refractory Multisystem Inflammatory Syndrome in Children
Case Report: Ciclosporin A for Refractory Multisystem Inflammatory Syndrome in Children Open
Multisystem inflammatory syndrome in children (MIS-C) is a new syndrome involving the development of severe dysfunction in multiple organs after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Because the pathophysi…
View article: Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery
Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery Open
Objective Patients who undergo Fontan surgery for complex cardiac anomalies are prone to developing liver and gastrointestinal complications. In particular, gastroesophageal varices (GEVs) can occur, but their prevalence is unknown. We aim…
View article: Food Preferences of Patients with Citrin Deficiency
Food Preferences of Patients with Citrin Deficiency Open
Citrin deficiency is characterized by a wide range of symptoms from infancy through adulthood and presents a distinct preference for a diet composed of high protein, high fat, and low carbohydrate. The present study elucidates the importan…
View article: Role of the Gut Microbiota in Regulating Non-alcoholic Fatty Liver Disease in Children and Adolescents
Role of the Gut Microbiota in Regulating Non-alcoholic Fatty Liver Disease in Children and Adolescents Open
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in children and adolescents. Although obesity is the leading cause of NAFLD, the etiologies of NAFLD are multifactorial (e.g., high-fat diet, a lack…
View article: COVID-19 phobia in a boy with undiagnosed autism spectrum disorder
COVID-19 phobia in a boy with undiagnosed autism spectrum disorder Open
Rationale: Coronavirus disease 2019 (COVID-19) is affecting mental health profoundly. Previous studies have reported pandemic-related anxiety. Anxiety disorder and autism spectrum disorder (ASD) are common comorbidities. However, there has…
View article: Analysis of daily energy, protein, fat, and carbohydrate intake in citrin-deficient patients: Towards prevention of adult-onset type II citrullinemia
Analysis of daily energy, protein, fat, and carbohydrate intake in citrin-deficient patients: Towards prevention of adult-onset type II citrullinemia Open
Patients with citrin deficiency during the adaptation/compensation period exhibit diverse clinical features and have characteristic diet of high protein, high fat, and low carbohydrate. Japanese cuisine typically contains high carbohydrate…
View article: Assessing liver stiffness with conventional cut‐off values overestimates liver fibrosis staging in patients who received the Fontan procedure
Assessing liver stiffness with conventional cut‐off values overestimates liver fibrosis staging in patients who received the Fontan procedure Open
Aim Patients who undergo the Fontan procedure for complex congenital heart disease are prone to liver cirrhosis. Liver stiffness (LS) reflects liver fibrosis stage in patients with chronic viral hepatitis; however, its accuracy in predicti…
View article: Cord Blood-Based Approach to Assess Candidate Vaccine Adjuvants Designed for Neonates and Infants
Cord Blood-Based Approach to Assess Candidate Vaccine Adjuvants Designed for Neonates and Infants Open
Neonates and infants are particularly susceptible to infections, for which outcomes tend to be severe. Vaccination is a key strategy for preventing infectious diseases, but the protective immunity achieved through vaccination typically is …
View article: COVID-19 phobia in a boy with undiagnosed autism spectrum disorder: a case report
COVID-19 phobia in a boy with undiagnosed autism spectrum disorder: a case report Open
BackgroundThe coronavirus disease (COVID-19) is affecting mental health profoundly. Previous studies have reported pandemic-related anxiety. Anxiety disorder and autism spectrum disorder (ASD) are relatively common comorbidities. However, …
View article: Normal liver stiffness and influencing factors in healthy children: An individual participant data meta‐analysis
Normal liver stiffness and influencing factors in healthy children: An individual participant data meta‐analysis Open
Background & Aims Although transient elastography (TE) is used to determine liver stiffness as a surrogate to hepatic fibrosis, the normal range in children is not well defined. We performed a systematic review and individual participant d…
View article: Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells
Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells Open
The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the …
View article: Oral esomeprazole in Japanese pediatric patients with gastric acid‐related disease: Safety, efficacy, and pharmacokinetics
Oral esomeprazole in Japanese pediatric patients with gastric acid‐related disease: Safety, efficacy, and pharmacokinetics Open
Background Proton pump inhibitors ( PPI ) are widely used for the treatment of gastric acid‐related disease, but they are not approved for use in children in Japan. To assess the safety, pharmacokinetics, pharmacodynamics, and efficacy (ga…
View article: A comprehensive understanding of the gut mucosal immune system in allergic inflammation
A comprehensive understanding of the gut mucosal immune system in allergic inflammation Open
Despite its direct exposure to huge amounts of microorganisms and foreign and dietary antigens, the gut mucosa maintains intestinal homeostasis by utilizing the mucosal immune system. The gut mucosal immune system protects the host from th…