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View article: Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing progressive paralysis due to motor neuron degeneration with no curative therapy despite extensive biomedical research. One of the primary targets of ALS is sk…
View article: Author Correction: Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy
Author Correction: Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy Open
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View article: Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy
Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy Open
View article: Author Correction: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis
Author Correction: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis Open
View article: Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle Open
View article: Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle Open
SUMMARY Striated muscle is a highly organized structure composed by well-defined anatomical domains with integrated but distinct assignments. So far, the lack of a direct correlation between tissue architecture and gene expression has limi…
View article: Activation of skeletal muscle–resident glial cells upon nerve injury
Activation of skeletal muscle–resident glial cells upon nerve injury Open
Here, we report on the identification of Itga7-expressing muscle-resident glial cells activated by loss of neuromuscular junction (NMJ) integrity. Gene expression analysis at the bulk and single-cell level revealed that these cells are dis…
View article: scRNA-seq-based analysis of skeletal muscle response to denervation reveals selective activation of muscle-resident glial cells and fibroblasts
scRNA-seq-based analysis of skeletal muscle response to denervation reveals selective activation of muscle-resident glial cells and fibroblasts Open
Summary Developmental synaptogenesis toward formation of neuromuscular junctions (NMJs) is regulated by the reciprocal exchange of signals derived from nerve or muscle ends, respectively. These signals are re-deployed in adult life to repa…
View article: Revealing the Therapeutic Potential of Botulinum Neurotoxin Type A in Counteracting Paralysis and Neuropathic Pain in Spinally Injured Mice
Revealing the Therapeutic Potential of Botulinum Neurotoxin Type A in Counteracting Paralysis and Neuropathic Pain in Spinally Injured Mice Open
Botulinum neurotoxin type A (BoNT/A) is a major therapeutic agent that has been proven to be a successful treatment for different neurological disorders, with emerging novel therapeutic indications each year. BoNT/A exerts its action by bl…
View article: Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic Target
Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic Target Open
View article: Fibro–Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network
Fibro–Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network Open
Skeletal muscle is composed of a large and heterogeneous assortment of cell populations that interact with each other to maintain muscle homeostasis and orchestrate regeneration. Although satellite cells (SCs) - which are muscle stem cells…
View article: Histaminergic transmission slows progression of amyotrophic lateral sclerosis
Histaminergic transmission slows progression of amyotrophic lateral sclerosis Open
Background Histamine is an immune modulator, neuroprotective, and remyelinating agent, beneficially acting on skeletal muscles and promoting anti‐inflammatory features in amyotrophic lateral sclerosis (ALS) microglia. Drugs potentiating th…
View article: Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1 <sup>G93G</sup> Mice Predates Disease Onset and is a Promising Therapeutic Target
Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1 <sup>G93G</sup> Mice Predates Disease Onset and is a Promising Therapeutic Target Open
View article: Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths?
Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths? Open
Skeletal muscle is a dynamic tissue capable of responding to a large variety of physiological stimuli by adjusting muscle fiber size, metabolism and function. However, in pathological conditions such as cancer and neural disorders, this fi…
View article: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis
Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis Open
View article: Role of miR‐200c in Myogenic Differentiation Impairment via p66Shc: Implication in Skeletal Muscle Regeneration of Dystrophic <i>mdx</i> Mice
Role of miR‐200c in Myogenic Differentiation Impairment via p66Shc: Implication in Skeletal Muscle Regeneration of Dystrophic <i>mdx</i> Mice Open
Duchenne muscular dystrophy (DMD) is a genetic disease associated with mutations of Dystrophin gene that regulate myofiber integrity and muscle degeneration, characterized by oxidative stress increase. We previously published that reactive…