Dajiang Du
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View article: Comparative analysis of scaffold-free tissue-engineered cartilage derived from different seed cells: <i>in vitro</i> and <i>in vivo</i> studies
Comparative analysis of scaffold-free tissue-engineered cartilage derived from different seed cells: <i>in vitro</i> and <i>in vivo</i> studies Open
Objective The development of cartilage tissue engineering offers a promising strategy for effective cartilage regeneration. This study aims to synthesize scaffold-free tissue-engineered cartilage (TEC) using articular chondrocytes (ACs), c…
View article: Association between impaired lung function and risk of spondyloarthritis: a cross-sectional study in the UK Biobank
Association between impaired lung function and risk of spondyloarthritis: a cross-sectional study in the UK Biobank Open
Background: Impaired lung function has been noted in individuals with spondyloarthritis (SpA). However, a comprehensive summary of the existing evidence related to these conditions is still lacking. Objective: The aim of the study is to ex…
View article: CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue Open
CD4+ TRM17 cells are the predominant source of IL-17A in SpA synovial tissue. TCR stimulation is essential for the secretion of IL-17A by CD4+TRM17-like cells. The epigenetic regulator bromodomain-containing protein 1 (BRD1) contributes to…
View article: Hip arthroscope-assisted percutaneous reduction and fixation of displaced subcapital femoral neck fracture
Hip arthroscope-assisted percutaneous reduction and fixation of displaced subcapital femoral neck fracture Open
Reduction quality is associated with fracture prognosis. Displaced subcapital femoral neck fracture has highest possibility of avascular necrosis of femoral head and non-union among the femoral neck fractures, which commonly necessitate re…
View article: Case report: Free autologous costal cartilage transplantation for osteochondral lesions of the talus: three cases with 2–5 years follow-up
Case report: Free autologous costal cartilage transplantation for osteochondral lesions of the talus: three cases with 2–5 years follow-up Open
Background Osteochondral lesions of the talus (OLT) is a common and clinically challenging condition with no consensus on the optimal treatment. The prospective case series aim to evaluate the feasibility and clinical outcomes of free auto…
View article: Repair of the femoral head osteochondral defect in a swine model using autologous costal cartilage graft transplantation
Repair of the femoral head osteochondral defect in a swine model using autologous costal cartilage graft transplantation Open
View article: CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue Open
Objectives Interleukin (IL)-17A is a key driver of Spondyloarthritis (SpA) joint pathology. We aimed to identify its cellular source in synovial tissue from patients with two forms of SpA namely Axial SpA (AxSpA) and Psoriatic arthritis (P…
View article: AxSpA joint tissue is characterised by HLA-DR<sup>+</sup>tissue resident memory (TRM) and killer cell immunoglobulin-like receptor (KIR)<sup>+</sup>CD8<sup>+</sup>T cell subsets
AxSpA joint tissue is characterised by HLA-DR<sup>+</sup>tissue resident memory (TRM) and killer cell immunoglobulin-like receptor (KIR)<sup>+</sup>CD8<sup>+</sup>T cell subsets Open
Objective Axial Spondyloarthritis (AxSpA) is a common inflammatory arthritis with HLA-B*27 as the major genetic risk. Recent discoveries of AxSpA-specific T cell receptor (TCR) motifs and the self and bacterial peptides that they recognize…
View article: Targeting Parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis
Targeting Parkin-regulated metabolomic change in cartilage in the treatment of osteoarthritis Open
Summary: Articular cartilage degeneration may lead to osteoarthritis (OA) during the aging process, but its underlying mechanism remains unknown. Here, we found that chondrocytes exhibited an energy metabolism shift from glycolysis to oxid…
View article: Enhanced articular cartilage regeneration using costal chondrocyte-derived scaffold-free tissue engineered constructs with ascorbic acid treatment
Enhanced articular cartilage regeneration using costal chondrocyte-derived scaffold-free tissue engineered constructs with ascorbic acid treatment Open
Cartilage tissue engineering is an area of research with immense clinical potential. The approach presented in this article offers a cost-effective and straightforward solution, which can minimize the complexity of cell culture and scaffol…
View article: Costal Cartilage Graft Repair Osteochondral Defect in a Mouse Model
Costal Cartilage Graft Repair Osteochondral Defect in a Mouse Model Open
Objective Osteochondral defects develop into osteoarthritis without intervention. Costal cartilage can be utilized as an alternative source for repairing osteochondral defect. Our previous clinical study has shown the successful osteochond…
View article: Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis
Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis Open
View article: Autologous Costal Cartilage Grafting for a Large Osteochondral Lesion of the Femoral Head
Autologous Costal Cartilage Grafting for a Large Osteochondral Lesion of the Femoral Head Open
Background: There is currently no ideal treatment for osteochondral lesions of the femoral head (OLFH) in young patients. Methods: We performed a 1-year single-arm study and 2 additional years of follow-up of patients with a large (defined…
View article: Treatment of Advanced Kienböck's Disease Using 3D Printing Assisted Autologous Costochondral Transplantation
Treatment of Advanced Kienböck's Disease Using 3D Printing Assisted Autologous Costochondral Transplantation Open
Case: We describe a patient with advanced Kienböck's disease, treated with 3-dimensional (3D) printing assisted costochondral transplantation. Cartilage shaping was achieved according to a biomimetic 3D-printed prosthesis designed by mirro…
View article: ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A
ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A Open
Background: Osteoarthritis (OA) is a highly degenerative joint disease, mainly companying with progressive destruction of articular cartilage. Adipose-derived stromal cells (ADSCs) therapy enhances articular cartilage repair, extracellular…
View article: Co-culture pellet of human Wharton’s jelly mesenchymal stem cells and rat costal chondrocytes as a candidate for articular cartilage regeneration: in vitro and in vivo study
Co-culture pellet of human Wharton’s jelly mesenchymal stem cells and rat costal chondrocytes as a candidate for articular cartilage regeneration: in vitro and in vivo study Open
Background Seeding cells are key factors in cell-based cartilage tissue regeneration. Monoculture of either chondrocyte or mesenchymal stem cells has several limitations. In recent years, co-culture strategies have provided potential solut…
View article: Case Report: Diagnosis of Mucopolysaccharidosis Type IVA With Compound Heterozygous Galactosamine-6 Sulfatase Variants and Biopsy of Replaced Femoral Heads
Case Report: Diagnosis of Mucopolysaccharidosis Type IVA With Compound Heterozygous Galactosamine-6 Sulfatase Variants and Biopsy of Replaced Femoral Heads Open
Introduction Mucopolysaccharidosis Type IVA (MPS IVA) or Morquio A Syndrome, is a rare metabolic disorder caused by compromised galactosamine-6 sulfatase (GALNS) encoded by GALNS gene (NM_000512.5), leading to keratin sulfate (KS), and cho…
View article: Anti-hypertrophic effect of synovium-derived stromal cells on costal chondrocytes promotes cartilage repairs
Anti-hypertrophic effect of synovium-derived stromal cells on costal chondrocytes promotes cartilage repairs Open
View article: Current surgical options and innovation for repairing articular cartilage defects in the femoral head
Current surgical options and innovation for repairing articular cartilage defects in the femoral head Open
View article: Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques
Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques Open
It is a great challenge to cure symptomatic lesions and considerable defects of hyaline cartilage due to its complex structure and poor self-repair capacity. If left untreated, unmatured degeneration will cause significant complications. S…
View article: Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering
Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering Open
Porous ceramic scaffolds with shapes matching the bone defects may result in more efficient grafting and healing than the ones with simple geometries. Using computer-assisted microstereolithography (MSTL), we have developed a novel gelcast…