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View article: Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway
Extrachromosomal DNA Gives Cancer a New Evolutionary Pathway Open
Studying tumor evolution has traditionally focused on individual cells gaining fitness advantages to outcompete their neighbors. However, this perspective may miss a crucial aspect of tumor resilience, particularly in cancers driven by ext…
View article: USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination Open
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. However, factors that prevent premature CMG un…
View article: APC/C prevents a noncanonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor–induced arrest
APC/C prevents a noncanonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor–induced arrest Open
Regulated cell cycle progression ensures homeostasis and prevents cancer. In proliferating cells, premature S phase entry is avoided by the E3 ubiquitin ligase anaphasepromoting complex/cyclosome (APC/C), although the APC/C substrates whos…
View article: APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest
APC/C prevents non-canonical order of cyclin/CDK activity to maintain CDK4/6 inhibitor-induced arrest Open
Regulated cell cycle progression ensures homeostasis and prevents cancer. In proliferating cells, premature S phase entry is avoided by the E3 ubiquitin ligase APC/C (anaphase promoting complex/cyclosome), although the APC/C substrates who…
View article: G1 Dynamics at the Crossroads of Pluripotency and Cancer
G1 Dynamics at the Crossroads of Pluripotency and Cancer Open
G1 cell cycle phase dynamics are regulated by intricate networks involving cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors, which control G1 progression and ensure proper cell cycle transitions. Moreover, adequate origin licen…
View article: G1 Dynamics at the Crossroads of Pluripotency and Cancer
G1 Dynamics at the Crossroads of Pluripotency and Cancer Open
G1 cell cycle phase dynamics are regulated by intricate networks involving cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors, which control G1 progression and ensure proper cell cycle transitions. Moreover, adequate origin licen…
View article: Quantitative profiling of adaptation to cyclin E overproduction
Quantitative profiling of adaptation to cyclin E overproduction Open
Cyclin E/CDK2 drives cell cycle progression from G1 to S phase. Despite the toxicity of cyclin E overproduction in mammalian cells, the cyclin E gene is overexpressed in some cancers. To further understand how cells can tolerate high cycli…
View article: A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance
A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance Open
Ribonucleoside monophosphate (rNMP) incorporation in genomic DNA poses a significant threat to genomic integrity. In addition to repair, DNA damage tolerance mechanisms ensure replication progression upon encountering unrepaired lesions. O…
View article: Quantitative Profiling of Adaptation to Cyclin E Overproduction
Quantitative Profiling of Adaptation to Cyclin E Overproduction Open
Cyclin E/CDK2 drives cell cycle progression from G1 to S phase. Cyclin E overproduction is toxic to mammalian cells, although the gene encoding cyclin E ( CCNE1 ) is overexpressed in some cancers. To gain insight into how cancer cells tole…